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Acceptance and commitment therapy for chronic pain: a quasiexperimental study

Terapia de aceitação e compromisso em grupo para dor crônica: estudo quase-experimental

Abstract

Objective

Chronic pain is an important health problem and affects both quality of life and mental health. This study assessed psychological inflexibility, pain intensity, quality of life, anxiety and depression symptoms, self-efficacy, and social support among patients with chronic pain.

Method

A quasiexperimental design was used to assess six adult participants pre- and post-group intervention (eight sessions) based on acceptance and commitment therapy.

Results

After the intervention, the patients experienced a reduction in psychological inflexibility, pain, and depression and anxiety symptoms and improvements in quality of life and self-efficacy. The quality of life and depression symptoms and the domains of quality of life and psychological inflexibility were negatively correlated.

Conclusion

Acceptance and commitment therapy is a promising treatment for the interdisciplinary treatment of the Pain Clinic.

Keywords
Acceptance and commitment therapy; Behavior Therapy; Chronic pain; Group psychotherapy; Health Psychology

Resumo

Objetivo

Dor crônica é um problema de saúde prevalente que acarreta prejuízos para qualidade de vida e saúde mental. Este estudo avaliou inflexibilidade psicológica, intensidade da dor, qualidade de vida, sintomas de ansiedade e de depressão, autoeficácia e suporte social em pacientes com dor crônica.

Método

Utilizou delineamento quase-experimental e os seis participantes adultos foram avaliados por meio de instrumentos no pré e pós-intervenção em grupo (oito sessões) com Terapia de Aceitação e Compromisso.

Resultados

Após a intervenção houve redução da inflexibilidade psicológica e da dor, melhora da qualidade de vida, redução dos sintomas de ansiedade e de depressão e aumento da autoeficácia. Houve correlação inversa entre qualidade de vida e sintomas de depressão e entre domínios da qualidade de vida e inflexibilidade psicológica.

Conclusão

Conclui-se que a Terapia de Aceitação e Compromisso é um tratamento promissor a ser integrado no atendimento interdisciplinar da Clínica de dor.

Palavras-chave
Terapia de aceitação e compromisso; Terapia Comportamental; Dor crônica; Psicoterapia de grupo; Psicologia em Saúde

Chronic pain is one of the main reasons people seek health care and one of the main causes of work disability, with serious psychosocial and economic consequences (Mills et al., 2019Mills, S. E. E., Nicolson, K. P., & Smith, B. H. (2019). Chronic pain: a review of its epidemiology and associated factors in population-based studies. British Journal of Anasthesia, 123(2), e273-e283. http://doi.org/10.1016/j.bja.2019.03.023
https://doi.org/10.1016/j.bja.2019.03.02...
). Its prevalence is higher among women, older people and people with lower educational levels. Chronic pain is associated with multiple diseases (e.g., fibromyalgia, cardiovascular diseases, and arthritis) and mental disorders (e.g., depression and anxiety). The most frequently used treatment is pharmacological, although a smaller group reports the use of nonpharmacological strategies (Carvalho et al., 2018Carvalho, R. C., Maglioni, C. B., Machado, G. B., Araújo, J. E., Silva, J. R. T., & Silva, M. L. (2018). Prevalence and characteristics of chronic pain in Brazil. A national internet-based survey study. Brazilian Journal of Pain, 1(4),331-338. http://dx.doi.org/10.5935/2595-0118.20180063
https://doi.org/10.5935/2595-0118.201800...
).

Many pain behaviors (e.g., facial expressions and pain reports) are adaptive in acute pain because they increase the likelihood of receiving help and care. When pain is chronic, however, these behaviors (e.g., constant complaints/reports of pain) can be treated punitively, since the repeated complaints can be tiring for those who hear them and can negatively affect the interaction between the patient and the context in which they live. Pain is therefore a complex event, and the biopsychosocial model must be considered to properly understand and manage it (Gatzounis et al., 2012Gatzounis, R., Schrooten, M. G. S., Crombez, G., & Vlaeyen, J. W. S. (2012). Operant Learning Theory in Pain and Chronic Pain Rehabilitation. Current Pain and Headache Reports, 16,117-126. http://doi.org/10.1007/s11916-012-0247-1
https://doi.org/10.1007/s11916-012-0247-...
).

Psychologists currently play an important role in pain clinics both worldwide (Kitz, 2017Kitz, J. M. R. J. (2017). Challenges of managing chronic pain. British Medical Journal, 356, ej741. https://doi.org/10.1136/bmj.j741
https://doi.org/10.1136/bmj.j741...
) and in Brazil, and psychological interventions have been evaluated in the country (Miyazaki et al., 2018Miyazaki, M. C. O. S., Santos Jr, R., & Cury, P. M. (2018). O trabalho do psicólogo em equipes interdisciplinares de dor crônica. In E. M. F. Seidl, M. C. O. S. Miyazaki, A. T. A. Ramos-Cerqueira, & N. A. M. Domingos (Orgs.), Psicologia da Saúde: Teorias, conceitos e práticas (p. 155-170). Juruá.) and in international studies (Agency for Healthcare Research and Quality, [AHRQ] 2017Agency for Healthcare Research and Quality (2017). Noninvasive, nonpharmacological treatment for chronic pain: a systematic review. Comparative Effectiveness Review, 18(209), 1-22. http://doi.org/10.23970/AHRQEPCCER209
https://doi.org/10.23970/AHRQEPCCER209...
). A recent systemic review has shown the relevance of four types of psychological interventions for pain management: cognitive–behavioral therapy, biofeedback, relaxation techniques, and Acceptance and Commitment Therapy (ACT) (AHRQ, 2017Agency for Healthcare Research and Quality (2017). Noninvasive, nonpharmacological treatment for chronic pain: a systematic review. Comparative Effectiveness Review, 18(209), 1-22. http://doi.org/10.23970/AHRQEPCCER209
https://doi.org/10.23970/AHRQEPCCER209...
).

The ACT is included in the third wave of behavioral therapies and is based on functional contextualism and relational frame theory, a behavioral theory of human language and cognition. According to relational frame theory, the core of human language and cognition is the “[…] learned and contextually controlled ability to arbitrarily relate events mutually and in combination, and to change the functions of specific events based on their relations to others” (Hayes et al., 2006Hayes, S. C., Luoma, J. B., Bond, F. W., Masuda, A., & Lillis, J. (2006). Acceptance and Commitment Therapy: model, processes, and outcomes. Behaviour Research and Therapy, 44, 1-25. http://doi.org/10.1016/j.brat.2005.06.006
https://doi.org/10.1016/j.brat.2005.06.0...
, p. 5).

The ACT psychopathology model is used to conceptualize cases and to design interventions. Psychological inflexibility is considered the essence of psychopathology or of suffering and “[…] characterizes behavior controlled by language and little driven by values” (Barbosa & Murta, 2014Barbosa, L. M., & Murta, S. G. (2014). Terapia de aceitação e compromisso: história, fundamentos, modelo e evidências. Revista Brasileira de Terapia Comportal e Cognitiva, 16, 34-49., p. 39). Psychological Flexibility (PF), on the other hand, is “[…] the ability to contact the present moment more fully as a conscious human being, and to change or persist in behavior when doing so serves valued ends” (Hayes et al., 2006Hayes, S. C., Luoma, J. B., Bond, F. W., Masuda, A., & Lillis, J. (2006). Acceptance and Commitment Therapy: model, processes, and outcomes. Behaviour Research and Therapy, 44, 1-25. http://doi.org/10.1016/j.brat.2005.06.006
https://doi.org/10.1016/j.brat.2005.06.0...
, p. 7). The PF model is therefore simultaneously a model of psychopathology, mental health, and psychological intervention (Barbosa & Murta, 2014Barbosa, L. M., & Murta, S. G. (2014). Terapia de aceitação e compromisso: história, fundamentos, modelo e evidências. Revista Brasileira de Terapia Comportal e Cognitiva, 16, 34-49.; Hayes et al., 2012Hayes, S. C., Strosahl, K. D., & Wilson, K. G. (2012). Acceptance and Commitment Therapy. The process and practice of mindful change (2nd ed.). Guilford Press.).

The goal of ACT is to place verbal and cognitive processes under better contextual control so the person has greater contact with the positive consequences of their behavior as part of a life lived according to their values. Healthy psychological functioning is associated with the person’s ability to respond adaptively to the constant changes that occur in their environments (Hayes et al., 2006Hayes, S. C., Luoma, J. B., Bond, F. W., Masuda, A., & Lillis, J. (2006). Acceptance and Commitment Therapy: model, processes, and outcomes. Behaviour Research and Therapy, 44, 1-25. http://doi.org/10.1016/j.brat.2005.06.006
https://doi.org/10.1016/j.brat.2005.06.0...
).

Contextual behavioral therapies – such as those based on acceptance, commitment, and mindfulness – are considered an improvement over the traditional cognitive–behavioral therapy model for pain management (McCracken & Vowles, 2014McCracken, L. M., & Vowles, K. E. (2014). Acceptance and commitment therapy and mindfulness for chronic pain. Model, process, and progress. American Psychologist, 69, 178-187. http://doi.org/10.1037/a0035623
https://doi.org/10.1037/a0035623...
). In patients with pain, acceptance involves the “[…] willingness to have pain while remaining able to actively choose to continue participating in their life as they want it to be” (Yang & McCracken, 2014Yang, S. Y., & McCracken, L. M. (2014). Acceptance and Commitment Therapy for chronic pain. Journal of Clinical Outcomes Management, 21(3). https://www.mdedge.com/jcomjournal/article/147127/pain/acceptance-and-commitment-therapy-chronic-pain
https://www.mdedge.com/jcomjournal/artic...
, section on acceptance).

Several studies provide data supporting the use of ACT for patients with chronic pain (Aytur et al., 2021Aytur, S. A., Ray, K. L., Meier, S. K., Campbell, J., Gendron, B., Waller, N., & Robin, D. A. (2021). Neural mechanisms of acceptance and commitment therapy for chronic pain: a network-based-fMRI approach. Frontiers in Hunam Neuroscience, 15. https://doi.org/10.3389/fnhum.2021.587018
https://doi.org/10.3389/fnhum.2021.58701...
; Hann & McCracken, 2014Hann, E. J., & McCracken, L. M. (2014). A systematic review of randomized controlled trials of Acceptance and Commitment Therapy for adults with chronic pain: outcome domains, design quality, and efficacy. Journal of Contextual Behavioral Science, 3, 217-227. http://doi.org/10.1016/j.jcbs.2014.10.001
https://doi.org/10.1016/j.jcbs.2014.10.0...
; McCracken & Vowles, 2014McCracken, L. M., & Vowles, K. E. (2014). Acceptance and commitment therapy and mindfulness for chronic pain. Model, process, and progress. American Psychologist, 69, 178-187. http://doi.org/10.1037/a0035623
https://doi.org/10.1037/a0035623...
; Rickardsson et al., 2021Rickardsson, J., Gentili, C., Holmström, L., Zetterqvist, V., Andersson, E., Persson, J., Lekander, M., Ljótsson, B., & Wicksell, R. K. (2021). Internet-delivery acceptance and commitment therapyas microlearning for chronic pain: a randomized controlled trial with 1-year follow-up. European Jounal of Pain, 25(5), 1-19 http://doi.org/10.1002/ejp.1723
https://doi.org/10.1002/ejp.1723...
; Yang & McCracken, 2014McCracken, L. M., & Vowles, K. E. (2014). Acceptance and commitment therapy and mindfulness for chronic pain. Model, process, and progress. American Psychologist, 69, 178-187. http://doi.org/10.1037/a0035623
https://doi.org/10.1037/a0035623...
). However, reviews indicate that further studies are needed for ACT to become a well-established intervention for chronic health problems, including pain (Du et al., 2021Du, S., Dong, J., Jin, S., Zhang, H., & Zhang, Y. (2021). Acceptance and commitment therapy for chronic pain conditions on functioning: a systematic review protocol. Jounal of Advanced Nursing, 77(1), 417-426. https://doi.org/10.1111/jan.14575
https://doi.org/10.1111/jan.14575...
; Feliu-Soler et al., 2018Feliu-Soler, A., Montesinos, F., Gutiérrez-Martínez, O., Scott, W., McCracken, L., & Luciano, J. (2018). Current status of acceptance and commitment therapy for chronic pain: a narrative review. Journal of Pain Research, 11, 2145-2159. http://doi.org/10.2147/jpr.s144631
https://doi.org/10.2147/jpr.s144631...
; Hann & McCracken, 2014Hann, E. J., & McCracken, L. M. (2014). A systematic review of randomized controlled trials of Acceptance and Commitment Therapy for adults with chronic pain: outcome domains, design quality, and efficacy. Journal of Contextual Behavioral Science, 3, 217-227. http://doi.org/10.1016/j.jcbs.2014.10.001
https://doi.org/10.1016/j.jcbs.2014.10.0...
; Hughes et al., 2017Hughes, L. S., Clark, J., Colclough, J. A., Dale, E., & McMillan, D. (2017). Acceptance and Commitment Therapy (ACT) for Chronic Pain. The Clinical Journal of Pain, 33(6), 552-568. http://doi.org/10.1097/ajp.0000000000000425
https://doi.org/10.1097/ajp.000000000000...
). The objective of this study is to evaluate a group intervention program based on ACT for patients with chronic pain treated at the outpatient Pain Clinic of a teaching hospital in the Sistema Único de Saúde (Unified Health System).

Method

Participants

Patients diagnosed with chronic pain treated in the Pain Clinic of a teaching hospital during 2018 were invited to participate in the study. A nonprobabilistic sample was obtained based on the following inclusion criteria: age between 18 and 70 years and diagnosis of chronic pain. The exclusion criteria were chronic cancer pain, presence of severe mental disorders (e.g., schizophrenia), abuse of alcohol or other substances, characteristics recorded in the medical records that hindered participation in the study (e.g., auditory deficit), and patients receiving any type of psychological intervention. Figure 1 shows the study flowchart.

Instruments

For the data collection, the Brazilian versions of the following instruments were used:

Acceptance and Action Questionnaire-II (AAQ-II): used to assess psychological inflexibility, consists of seven questions, with answers ranging from 1 (“never”) to 7 (“always”) on a Likert-type scale. Its score ranges from 7 to 49 points, with higher scores indicating greater psychological inflexibility. The mean scores of a clinical population were 28.3 ± 9.9, and those of a nonclinical population were 18.51 ± 7.05 (Barbosa & Murta, 2015Barbosa, L. M., & Murta, S. G. (2015). Propriedades psicométricas iniciais do Acceptance and Action Questionnaire – II – versão brasileira. Psico-USF, 20, 75-85. http://doi.org/10.1590/1413-82712015200107
https://doi.org/10.1590/1413-82712015200...
; Bond et al., 2011Bond, F. W., Hayes, S. C., Baer, R. A., Carpenter, K. M., Guenole, N., Orcutt, H. K., Waltz, T., & Zettle, R. D. (2011). Preliminary psychometric properties of the acceptance and action questionnaire-II: a revised measure of psychological inflexibility and experiential avoidance. Behavior Therapy, 42, 676-688. http://doi.org/10.1016/j.beth.2011.03.007
https://doi.org/10.1016/j.beth.2011.03.0...
).

Visual Analog Scale for Pain (VAS): consists of a 10-cm ruler, on which each centimeter represents a number that indicates pain intensity (Rocha et al., 2016Rocha, L. C., Mesquita, L. P., Leite, A. C. S., & Cavalcante, M. L. S. N. (2016). Confiabilidade de escalas de avaliação da dor no paciente com câncer. In UECE (Org.), Anais do II Seminário Internacional de Integração Institucional Ensino, Pesquisa e Serviço (SIEPS). Fortaleza. http://www.uece.br/eventos/seminarioppcclisenfermaio/anais/edicao_2016.html
http://www.uece.br/eventos/seminarioppcc...
). The participants were asked to indicate the intensity of their pain at that moment, with higher values indicating greater pain intensities.

Inventory of the Quality of Life (SF-36): consists of 36 items divided into eight domains: functional capacity, physical aspects, pain, and general health status (physical components) and vitality, social aspects, emotional aspects, and mental health (mental components). For each domain, the items are coded and transformed on a scale ranging from zero (worst quality of life) to 100 points (best quality of life) (Ciconelli et al.,1999Ciconelli, R. M., Ferraz, M. B., Santos, W., Meinão, I., & Quaresma, M. (1999). Tradução para a língua portuguesa e validação do questionário genérico de avaliação de qualidade de vida SF-36 (Brasil SF-36). Revista Brasileira de Reumatologia, 39,143-150.).

Beck Anxiety Inventory (BAI): consists of 21 items ranging from 0 to 3 points on a Likert-type scale. Higher scores indicate anxiety symptoms that are more intense. The total score can be classified as minimal (0 to 10), mild (11 to 19), moderate (20 to 30), or severe (31 to 63) (Cunha, 2001Cunha, J. A. (2001). Manual da versão em português das escalas Beck. Casa do Psicólogo.).

Beck’s Depression Inventory (BDI): consists of 21 items, ranging from 0 to 3 points on a Likert-type scale. Higher scores indicate depression symptoms that are more intense. The total score can be classified as minimal (0 to 11), mild (12 to 19), moderate (20 to 35), or severe (36 to 63) (Cunha, 2001Cunha, J. A. (2001). Manual da versão em português das escalas Beck. Casa do Psicólogo.).

Chronic Pain Self-efficacy Scale (CPSS): is a 22-item instrument that identifies beliefs about the personal ability to perform activities or achieve results related to pain, coping, and functionality (Salvetti & Pimenta, 2005Salvetti, M. G., & Pimenta, C. A. M. (2005). Validação da Chronic Pain Self-Efficacy Scale para a Língua Portuguesa. Revista de Psiquiatria Clínica, 32, 202-210. http://doi.org/10.1590/S0101-60832005000400002
https://doi.org/10.1590/S0101-6083200500...
).

Medical Outcomes Study - Social Support Scale (MOS-SSS): is composed of 19 domains, grouped into five support dimensions: informational, emotional, positive social interaction, material, and affective. The scale evaluates the frequency with which each support type is perceived by the patient, and each domain has five response options on a Likert-type scale, ranging from 1 (“never”) to 5 (“always”) (Zanini et al., 2018Zanini, D. S., Peixoto, E. M., & Nakano, T. D. C. (2018). Escala de apoio social (MOS-SSS): proposta de normatização com referência nos itens. Trends in Psychology, 26(1), 387-399. http://doi.org/10.9788/tp2018.1-15pt
https://doi.org/10.9788/tp2018.1-15pt...
).

Procedures

The participants attended eight sessions (one session per week) for two months (June to August 2018), and each session lasted approximately one and a half hours (90 minutes). All the sessions were structured based on an ACT protocol3 3 The protocol features were conducted in organized sessions that discussed the bases and options for treatment (Sessions 1 and 2); learning to live with chronic pain (Session 3); the importance of values and actions (Session 4); the relationship between impulses, thoughts, and desires (Session 5); the need for action (Session 6); a commitment to change (Session 7); and, finally, the maintenance of long-term benefits (Session 8). A detailed description of the intervention is available in Miyazaki (2019). for chronic pain (Miyazaki, 2019Miyazaki, E. S. (2019). Terapia de Aceitação e Compromisso em grupo para pacientes com dor crônica [Unpublished doctoral dissertation]. Faculdade de Medicina de São José do Rio Preto.; Vowles & Sorrell, 2007Vowles, K. E., & Sorrell, J. T. (2007). Life with Chronic pain: an acceptance-based approach. Centre for Pain Research, School for Health, University of Bath. https://contextualscience.org/files/CP_Acceptance_Manual_09.2008.pdf
https://contextualscience.org/files/CP_A...
). Informal language was used to facilitate the learning of the ACT technical terms and concepts (Miyazaki, 2019Miyazaki, E. S. (2019). Terapia de Aceitação e Compromisso em grupo para pacientes com dor crônica [Unpublished doctoral dissertation]. Faculdade de Medicina de São José do Rio Preto.), and a minimum frequency of 70% was established to characterize the intervention. Demographic, clinical, and evaluation instruments were collected at the beginning of the study (pre-intervention evaluation). After the intervention, the instruments were reapplied (postintervention evaluation). The professional who led the sessions was trained in contextual therapies, had experience (more than five years) in clinical care to conduct the groups, and was supervised by an experienced therapist and reference in the area.

The study was approved by the Research Ethics Committee – CAAE 77680517.8.0000.5415 and Opinion nº 2,336,735.

Data Analysis

The instrument collection and correction were performed by the therapist who led the group and two other professionals (co-therapists) who volunteered and were trained for the task. The intervention was part of the doctoral thesis of the first author.

The exploratory data analysis included the means, medians, standard deviations, and variations for the continuous variables and the numbers and proportions for the categorical variables. The normal distribution of the continuous variables was assessed by skewness, kurtosis, and the Kolmogorov-Smirnov test. Comparisons of the variables between the related groups (pre- and postintervention) were performed with a paired t test (for the continuous variables) or the Wilcoxon signed-rank test (for the categorical variables). The categorical variables were compared using McNemar’s chi-squared test. The statistical analysis was performed using IBM®SPSS® Statistics version 24 (IBM Corporation, NY, USA).

Results

Of the 88 patients screened at the Pain Clinic of a high-complexity teaching hospital in 2018, 16 met the inclusion criteria and were invited to participate in the intervention. Only eight agreed to participate, and six completed the intervention (Figure 1). Among the six patients who completed the intervention, three were women and three were men, with a mean age of 52.16 ± 5.63 years. All were in a stable relationship. The duration of the pain ranged from two to 17 years (11.5 ± 5.78).

Figure 1
Study flowchart: Selection criteria for participation in the group acceptance and commitment therapy for patients with chronic pain

Table 1 shows the pre- and postintervention results measured by the instruments used to evaluate pain, anxiety symptoms, depression symptoms, psychological inflexibility, self-efficacy, and social support. After the intervention, there was a statistically significant reduction in the perceived pain (p = 0.026), anxiety symptoms (p = 0.028), and depression symptoms (p = 0.028). The depression scores decreased categorically for four of the six participants. One went from mild to minimal, one went from moderate to mild, one went from severe to mild and one went from severe to moderate. Among those who did not experience a change, one remained in the minimal category and the other remained in the moderate category. The anxiety scores decreased in the category for five of the six participants. One went from severe to mild, two went from severe to moderate, one went from moderate to minimal, and one went from moderate to mild. The participants who did not change categorically remained in the minimal category.

Table 1
Comparative analysis of the patients evaluated pre- and postintervention (ACT) regarding pain perception (VAS), anxiety symptoms (BAI), depression symptoms (BDI), psychological inflexibility (AAQ-II), and self-efficacy (CPSS)

The AAQ-II scores indicated that psychological inflexibility decreased from the pre- to the postintervention evaluation for all the participants, but this difference was not statistically significant. The mean participant score after the intervention (18.16), however, was below the mean score of nonclinical populations (mean 18.51 ± 7.05) (Bond et al., 2011Bond, F. W., Hayes, S. C., Baer, R. A., Carpenter, K. M., Guenole, N., Orcutt, H. K., Waltz, T., & Zettle, R. D. (2011). Preliminary psychometric properties of the acceptance and action questionnaire-II: a revised measure of psychological inflexibility and experiential avoidance. Behavior Therapy, 42, 676-688. http://doi.org/10.1016/j.beth.2011.03.007
https://doi.org/10.1016/j.beth.2011.03.0...
), indicating that, although the difference was not statistically significant, there was a clinically significant difference after the intervention.

For self-efficacy, all the patients had increased scores after the intervention. The sum of the self-efficacy means, self-efficacy for pain control, functionality and coping with other symptoms underwent statistically significant improvements. However, these increases were not statistically significant for the total instrument score. Before the intervention, all the patients had a score below 185, which is considered the cutoff score for self-efficacy for chronic pain (Salvetti & Pimenta, 2005Salvetti, M. G., & Pimenta, C. A. M. (2005). Validação da Chronic Pain Self-Efficacy Scale para a Língua Portuguesa. Revista de Psiquiatria Clínica, 32, 202-210. http://doi.org/10.1590/S0101-60832005000400002
https://doi.org/10.1590/S0101-6083200500...
). After the intervention, only two of the six patients had a score below 185, and even these patients had increased scores in the postintervention evaluation.

The scores for social support in the material, affective, emotional, and informational dimensions increased after the intervention, but the pre- and postevaluations exhibited no significant difference.

Table 2 shows the comparative analysis of the quality of life before and after the intervention. After the intervention, functional capacity, pain, vitality, social aspect, emotional aspect, and mental health significantly improved. Although after the intervention, the scores improved for the physical aspects and general health status, the difference was not significant. These data improved in several of the quality-of-life domains because of the therapy.

Table 2
Comparative analysis of the quality of life (SF-36) pre- and postintervention (ACT) for chronic pain

Table 3 shows the correlations obtained through the application of the instruments that evaluated the quality-of-life domains and the anxiety symptoms, depression symptoms, and psychological inflexibility pre- and postintervention. The main correlations with the quality of life were found for depression symptoms and PF. This result is possibly related to the increase in the rate of behaviors displayed by the study participants, since pain took on a secondary role in their lives, which allowed greater social interactions, the display of more adaptive behaviors, and increased occurrence of reinforcers.

Table 3
Correlation analysis* * Considered for patients with a score greater than 24 points. between the SF-36 domains and the BDI, BAI, AAQ-II scores pre- and postintervention

The patient reports during the intervention were recorded and may exemplify the acceptance of and commitment to living a value-driven life despite the pain. The data obtained through the instrument application signaled changes, and the statements help to understand how the values and changes in their life were perceived by each patient: 1) “Caring for my granddaughter is one of the reasons to get out of bed every day despite the pain”. 2) “My son called me to look at paintings. Before, I would not go. Now, I go. I laid on his bed and gave my opinion”. 3) “Before, I thought that pain controlled everything. Nowadays, I know that pain is just a small part of it. ... I can understand that pain is a part, but neither the greatest nor the most important part. I am more than pain. I am a father, I am a husband”. 4) “The worst is not when I isolate myself because of the pain but when it goes away and you realize you missed out on the whole day”. 5) “Before, I did nothing. I liked to play in the church, but I was in pain and therefore would not go. I understood that I could feel pain and still go. I liked the dynamics of the clay on the windshield” (refers to an experiential exercise performed in session, which focused on accepting adverse situations without attempting to change them, as such attempt worsens the situation).

The patients’ statements indicated that they considered changes to have occurred because of the therapeutic process: there is a possibility beyond pain. After values that made sense for each participant were identified (e.g., being a good father or being a good grandmother), a new perspective appeared, enabling not only the acceptance of pain but also engagement in reinforcing activities.

Discussion

Psychological inflexibility, a key concept of ACT, seems to play an important role in emotional distress and pain (Gentili et al. 2019Gentili, C., Rickardsson, J., Zetterqvist, V., Simons, L. E., Lekander, M., & Wicksell, R. K. (2019). Psychological Flexibility as a Resilience Factor in Individuals with Chronic Pain. Frontiers in Psychology, 10. https://doi.org/10.3389/fpsyg.2019.02016
https://doi.org/10.3389/fpsyg.2019.02016...
; Rickardsson et al., 2021Rickardsson, J., Gentili, C., Holmström, L., Zetterqvist, V., Andersson, E., Persson, J., Lekander, M., Ljótsson, B., & Wicksell, R. K. (2021). Internet-delivery acceptance and commitment therapyas microlearning for chronic pain: a randomized controlled trial with 1-year follow-up. European Jounal of Pain, 25(5), 1-19 http://doi.org/10.1002/ejp.1723
https://doi.org/10.1002/ejp.1723...
). Although the AAQ-II scores pre- and postintervention exhibited no statistically significant difference, the increase in PF seems to have been sufficient to improve pain management, since the patients perceived a significantly lower intensity of pain. The patients’ psychological inflexibility clinically reduced; that is, most moved from the dysfunctional to the functional group according to the AAQ-II scores (Jacobson & Truax, 1991Jacobson, N. S., & Truax, P. A. (1991). Clinical significance: a statistical approach to defining meaningful change in psychotherapy research. Journal of Consulting and Clinical Psychology, 59(1), 12-19. http://doi.org/10.1037//0022-006x.59.1.12
https://doi.org/10.1037//0022-006x.59.1....
). Thus, the data obtained are compatible with other studies, which indicate that the reduction in psychological inflexibility plays an important role in the adaptation of patients to chronic pain (Gentili et al., 2019Gentili, C., Rickardsson, J., Zetterqvist, V., Simons, L. E., Lekander, M., & Wicksell, R. K. (2019). Psychological Flexibility as a Resilience Factor in Individuals with Chronic Pain. Frontiers in Psychology, 10. https://doi.org/10.3389/fpsyg.2019.02016
https://doi.org/10.3389/fpsyg.2019.02016...
; Rickardsson et al., 2021Rickardsson, J., Gentili, C., Holmström, L., Zetterqvist, V., Andersson, E., Persson, J., Lekander, M., Ljótsson, B., & Wicksell, R. K. (2021). Internet-delivery acceptance and commitment therapyas microlearning for chronic pain: a randomized controlled trial with 1-year follow-up. European Jounal of Pain, 25(5), 1-19 http://doi.org/10.1002/ejp.1723
https://doi.org/10.1002/ejp.1723...
).

The choice to live a value-driven life, one of the processes associated with the reduction in psychological inflexibility, was observed, as in another study (Casey et al., 2020Casey, M., Murphy, D., Neary, R., Wade, C. Hearty, C., & Doody, C. (2020). Individuals’ perspectives related to acceptance, values and mindfulness following participation in an ACT based management program. Journal of Contextual Behavioral Science, 16, 96-102. https://doi.org/10.1016/j.jcbs.2020.03.005
https://doi.org/10.1016/j.jcbs.2020.03.0...
), in the patient reports during the intervention. These data are consistent with the ACT premise that psychological inflexibility is associated with pain and suffering, preventing the person from adapting to their context and life situation. On the other hand, the increased flexibility allows the person to have contact with the consequences of their behavior in the present and to live according to their values (Casey et al., 2020Casey, M., Murphy, D., Neary, R., Wade, C. Hearty, C., & Doody, C. (2020). Individuals’ perspectives related to acceptance, values and mindfulness following participation in an ACT based management program. Journal of Contextual Behavioral Science, 16, 96-102. https://doi.org/10.1016/j.jcbs.2020.03.005
https://doi.org/10.1016/j.jcbs.2020.03.0...
; Hayes et al., 2012Hayes, S. C., Strosahl, K. D., & Wilson, K. G. (2012). Acceptance and Commitment Therapy. The process and practice of mindful change (2nd ed.). Guilford Press.). This correlation was evidenced in the data of the present article, which showed changes in the correlations between the AAQ-II and the SF-36 pre- (no statistically significant correlation) and postintervention (statistically significant correlation between the AAQ-II and the SF-36 in the domains of physical aspects [p = 0.032], social aspects [p = 0.003], and mental health [p = 0.020]).

Yu et al. (2017)Yu, L., Norton, S., & McCracken, L. M. (2017). Change in “self-as-context” (“perspective-taking”) occurs in acceptance and commitment therapy for people with chronic pain and is associated with improved functioning. Journal of Pain, 18(6), 664-672. http://doi.org/10.1016/j.jpain.2017.01.005
https://doi.org/10.1016/j.jpain.2017.01....
concluded that ACT-based treatment caused changes in the “self as context” and in comprehensive distancing, helping patients cope with chronic pain. The distancing from the “conceptualized self” and the search for the “self as context” enables a change in the perspective towards the event and helps the patient manage the current situation by allowing a type of cognitive defusion, that is, a change in the way the patient interacts with their thoughts, reducing their harmful effects on behavior (Hayes et al., 2006Hayes, S. C., Luoma, J. B., Bond, F. W., Masuda, A., & Lillis, J. (2006). Acceptance and Commitment Therapy: model, processes, and outcomes. Behaviour Research and Therapy, 44, 1-25. http://doi.org/10.1016/j.brat.2005.06.006
https://doi.org/10.1016/j.brat.2005.06.0...
). Accepting pain and displaying responses that can produce positive reinforcers indicate that, despite the pain, living a worthwhile life is possible.

Although the objective of the intervention performed in this study was not to reduce pain directly, the participants’ pain scores decreased significantly, as indicated by the VAS. The acceptance of pain and the commitment to the resumption or introduction of reinforcing activities in their daily lives helped the patients gain control of contingencies (e.g., experiencing reinforcing situations, such as discussing paintings with a child despite the pain) than under the control of self-rules (e.g., “I cannot go out because I will feel a lot of pain”). In this sense, it is evident that value-oriented actions can help patients manage everyday situations and cope with potentially aversive situations (e.g., the possibility of pain). That is, although there is an aversive component (pain), there is also the possibility of the reinforcing event (e.g., caring for the granddaughter or relating to family members).

Given the impact of pain on overall functioning, studies have evaluated the quality of life of patients with chronic pain. The data obtained in this study are consistent with the literature, which associates pain with a worse quality of life and shows a relationship between pain reduction and an increased quality of life (Samani et al., 2019Samani, M. G., Najafi, M., & Bouger, I. R. (2019). Comparing the effectiveness of acceptance and commitment therapy and physiotherapy on quality of life and pain catastrophizing in patients with chronic pain. Journal of Shahrekord University of Medical Sciences, 21(6), 271-275. http://doi.org/10.34172/jsums.2019.47
https://doi.org/10.34172/jsums.2019.47...
). The escape and avoidance of situations that require movement, avoided by patients with chronic pain, are also associated with a worse quality of life. In this study, the patients’ reports showed how much they avoided certain behaviors due to pain, leading to the loss of important reinforcers and causing a negative impact on the quality of life. On the other hand, the reports also showed the impact that the intervention had on the patient relationships and the quality of life.

The domains with the worst quality-of-life scores (SF-36) in the pre-intervention were the physical aspects and pain, and in the postintervention, they were the general health status and physical aspects. These data are consistent with the results of a study conducted in the same outpatient clinic (Martins et al., 2017Martins, M. R. I., Cunha, A. M. R. D., Forni, J. E. N., Santos Junior, R., Dias, L. C., & Araujo Filho, G. M. (2017). Self-perception of quality of life and identification of alexithymia in failed back surgery syndrome patients. Revista Dor, 18(1), 23-26. http://doi.org/10.5935/1806-0013.20170006
https://doi.org/10.5935/1806-0013.201700...
). Therefore, this study’s patients may not have experienced a greater improvement in the physical domain because, despite the improvement observed in pain, pain continued to be present.

The literature has shown a relationship between quality of life, pain, anxiety symptoms, and depression symptoms. Björnsdóttir et al. (2017)Björnsdóttir, S. V., Triebel, J., Arnljótsdóttir, M., Tómasson, G., & Valdimarsdóttir, U. A. (2017). Long-lasting improvements in health-related quality of life among women with chronic pain, following multidisciplinary rehabilitation. Disability and Rehabilitation, 40(15), 1764-1772. https://doi.org/10.1080/09638288.2017.1312565
https://doi.org/10.1080/09638288.2017.13...
concluded that a mindfulness-based interdisciplinary intervention with a pain specialist team was effective in managing long-term chronic musculoskeletal pain (six-month follow up). The present study also used mindfulness in part of the intervention, which specifically helped the participants come into contact with the present and break the link established between pain and other facets of life (e.g., being stuck in thoughts and self-rules). The analysis of the pre- and postintervention data for the correlations between the quality of life and the depression and anxiety symptoms measured by the SF-36, BDI, and BAI were also aligned with the data found in the literature.

Patients with chronic pain experience a consistent loss of reinforcers resulting from the limitation or reduction of activities. This loss occurs not only through pain but also through self-rules and verbal constraints (e.g., going out makes my pain worse), which can become a conditioned aversive stimulus, maintained through negative reinforcement (Luque-Suarez et al., 2018Luque-Suarez, A., Martinez-Calderon, J., & Falla, D. (2018). Role of kinesiophobia on pain, disability, and quality of life in people suffering from chronic pain: a systematic review. British Journal of Sports Medicine, 53(9), 1-8. http://doi.org/10.1136/bjsports-2017-098673
https://doi.org/10.1136/bjsports-2017-09...
), which increases the probability of escape or avoidance responses. In this study, the relationship “social activities worsen pain intensity” was deconstructed during the intervention, which allowed the decrease in control by rules and the increase in control by contingencies. This is one of the ACT’s proposals, especially using cognitive defusion. The intervention also helps the patient to behave under the control of delayed reinforcement and not under the control of the elimination of the aversive stimulus.

The present study found a statistically significant clinical manifestation of depression symptoms. At some points, the groups discussed behavioral patterns aimed at developing repertoires as an alternative to escape and avoidance and related to obtaining positive reinforcers. The use of metaphors and mindfulness exercises at the end of each session also helped the participants to cope with aversive stimuli in the short term to obtain reinforcers in the medium and long terms (Report 5). This training, combined with behavioral therapies, has shown promising results in the treatment of depression in patients with chronic pain (De Jong et al., 2018De Jong, M., Peeters, F., Gard, T., Ashih, H., Doorley, J., Walker, R., & Hoge, E. A. (2018). A randomized controlled pilot study on mindfulness-based cognitive therapy for unipolar depression in patients with chronic pain. Journal of Clinical Psychiatry, 79(1), 15m10160. http://doi.org/10.4088/JCP.15m10160
https://doi.org/10.4088/JCP.15m10160...
; Vowles et al., 2020Vowles, K. E., Pielech, M., Edwards, K. A., McEntee, M. L., & Bayley, R. W. (2020). A comparative meta-analisis of unidisciplinary psychology and interdisciplinary treatment outcomes following acceptance and commitment therapy for adults with chronic pain. The Journal of Pain, 21(5-6), 529-545. http://doi.org/10.1016/j.jpain.2019.10.004
https://doi.org/10.1016/j.jpain.2019.10....
). Cheng et al. (2018)Cheng, S. T., Leung, C. M., Chan, K. L., Chen, P. P., Chow, Y. F., Chung, J. W., & Tam, C. W. (2018). The relationship of self-efficacy to catastrophizing and depressive symptoms in community-dwelling older adults with chronic pain: a moderated mediation model. Plos One, 13(9), e0203964 http://doi.org/10.1371/journal.pone.0203964
https://doi.org/10.1371/journal.pone.020...
evaluated the relationship between depressive symptoms in adults and pain self-efficacy and concluded that self-efficacy is a protective factor for depressive symptoms. The reduction in depressive symptoms, in turn, can improve the quality of life of patients with chronic pain.

Social support can also contribute to an improved quality of life (Finlay et al., 2018Finlay, K. A., Peacock, S., & Elander, J. (2018). Developing successful social support: an interpretative phenomenological analysis of mechanisms and processes in a chronic pain support group. Psychology and Health, 33(7), 846-871. http://doi.org/10.1080/08870446.2017.1421188
https://doi.org/10.1080/08870446.2017.14...
). It involves relationships (person–person or person–person–environment) that can be explained by the selection-by-consequences model (Skinner, 1981Skinner, B. F. (1981). Selection by consequences. Science, 213(4507), 501-504. http://doi.org/10.1017/S0140525X0002673X
https://doi.org/10.1017/S0140525X0002673...
). Although the study found no statistical correlation between these variables, several of the participant reports affirmed the importance of this relationship (Reports 1, 2 and 3). To better understand these relationships, it is necessary to look at the intertwining of contingencies, which indicates the importance of two or more people in a relationship (Glenn, 1991Glenn, S. S. (1991). Contingencies and metacontingencies: Relations among behavioral, cultural, and biological evolution. In P. A. Lamal (Ed.), Behavioral Analysis of Societies and Cultural Practices (pp. 39-73). Hemisphere Press.) and highlights the importance of the context in which “pain behavior” occurs.

The mediating value of reinforcement results in some noteworthy implications. Social reinforcement usually depends on the occurrence of a response. In addition, the condition of the reinforcing agent may vary, which leads to variation in the reinforcement. A third implication is the slow change in some contingency characteristics. Finally, the reinforcement scheme is rarely adjusted inorganically by the reinforcing agent (Skinner, 1953/2003Skinner, B. F. (2003). Ciência e comportamento humano (J. C. Todorov & R. Azzi, Trads.; 10th ed.). Martins Fontes. (Original work published 1953).). The following changes were observed during the sessions: the change in the participant’s behavior resulted in a change in the relationships around them and consequently a change in the reinforcement relationships.

The operant relationship in chronic pain was first evidenced by Fordyce (1976)Fordyce, W. E. (1976). Behavioral methods for chronic pain and illness. Mosby., which highlights the need to study social support for chronic pain. The chronic nature of pain means the subject experiencing the pain and the people around them must develop skills to manage the situation. The present study compared the social support available before and after the intervention. Although the instrument scores increased, the increase was not statistically significant. The group was expected to serve as an important source of both social support for the participants and skill development to manage pain. These were both supposed to develop based on the statements and strategies used by the other participants and on the repertoire developed through the participants’ contact with their peers, the participants’ access to the material, and their discussions with health professionals.

The lack of a significant increase in social support scores could be due to two possibilities. The first is that, unlike in Finlay et al. (2018)Finlay, K. A., Peacock, S., & Elander, J. (2018). Developing successful social support: an interpretative phenomenological analysis of mechanisms and processes in a chronic pain support group. Psychology and Health, 33(7), 846-871. http://doi.org/10.1080/08870446.2017.1421188
https://doi.org/10.1080/08870446.2017.14...
, these participants did not know each other previously. The second is that they already had adequate social support before the intervention, and their group participation did not appreciably change that situation.

Conclusion

The present study concludes that the group treatment with ACT was effective for the participants, resulting in a statistically significant reduction in pain, anxiety and depression symptoms, and psychological inflexibility and a statistically significant improvement in the participants’ quality of life and self-efficacy scores. However, the small number of participants and the study design require further research. An additional important aspect to be included in future studies is a sleep evaluation, given that it is often altered in patients with chronic pain.

  • 3
    The protocol features were conducted in organized sessions that discussed the bases and options for treatment (Sessions 1 and 2); learning to live with chronic pain (Session 3); the importance of values and actions (Session 4); the relationship between impulses, thoughts, and desires (Session 5); the need for action (Session 6); a commitment to change (Session 7); and, finally, the maintenance of long-term benefits (Session 8). A detailed description of the intervention is available in Miyazaki (2019)Miyazaki, E. S. (2019). Terapia de Aceitação e Compromisso em grupo para pacientes com dor crônica [Unpublished doctoral dissertation]. Faculdade de Medicina de São José do Rio Preto..

Acknowledgments

The authors would like to thank the professionals at the pain clinic for their collaboration through patient referrals and data access.

  • How to cite this article: Miyazaki, E. S., Banaco, R. A., Domingos, N. A. M., Martins, G. B., & Miyazaki, M. C. O. S. (2023). Acceptance and commitment therapy for chronic pain: a quasiexperimental study. Estudos de Psicologia (Campinas), 40, e210067. https://doi.org/10.1590/1982-0275202340e210067
  • Support

    Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (Process nº 310499/2018-6)

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Edited by

Editor

André Luiz Monezi de Andrade

Publication Dates

  • Publication in this collection
    01 May 2023
  • Date of issue
    2023

History

  • Received
    12 Apr 2021
  • Reviewed
    02 Feb 2022
  • Accepted
    15 June 2022
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E-mail: psychologicalstudies@puc-campinas.edu.br