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Revista Latino-Americana de Enfermagem

On-line version ISSN 1518-8345

Rev. Latino-Am. Enfermagem vol.19 no.6 Ribeirão Preto Nov./Dec. 2011

http://dx.doi.org/10.1590/S0104-11692011000600024 

ORIGINAL ARTICLE

 

Prognosis of breast cancer during pregnancy: evidence for nursing care

 

 

Ana Fátima Carvalho FernandesI; Míria Conceição Lavinas SantosII; Tiago Barreto de Castro e SilvaIII; Cristina Maria GalvãoIV

I RN, Ph.D. in Nursing, Associate Professor, Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza, CE, Brazil. E-mail: afcana@ufc.br.
II RN, Ph.D. in Nursing, Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza, CE, Brazil. E-mail: mlavinas@fortalnet.com.br.
III RN, M.Sc. in Sciences. E-mail: tiagobcs@live.com.
IV RN, Ph.D. in Nursing, Full Professor, Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, WHO Collaborating Centre for Nursing Research Development, SP, Brazil. E-mail: crisgalv@eerp.usp.br.

Corresponding Author

 

 


ABSTRACT

This integrative review analyzed evidence available in the literature concerning the prognosis of breast cancer during pregnancy. The following databases were used for selecting studies: PubMed, CINAHL and LILACS. A total of 240 primary studies were identified; 13 papers were included in the integrative review’s sample after reading the titles and abstracts and according to the established inclusion and exclusion criteria. There is evidence indicating that pregnancy does not worsen the evolution of breast cancer and a poor prognosis is related to late stage tumors. Among the gaps identified in the studied theme, the need for further studies addressing nursing care provided to pregnant women with breast cancer is highlighted in order to promote improved care in the context of health care.

Descriptors: Breast Neoplasm; Pregnancy; Prognosis; Nursing.


 

 

Introduction

One of the problems that most seriously affects women in all aspects of life is the diagnosis of breast cancer, which is probably the most feared diagnosis among the female population given its increased incidence and the psychological and social impact it causes, especially due to the atmosphere of fear and taboo that surround such a disease(1).

According to estimates published by the Brazilian Cancer Institute (INCA), the number of new cases of breast cancer expected for Brazil in 2010 is 49,240, with an estimated risk of 49.27 cases/100,000 women. The estimates present a total of 8,270 new cases for the northeast: 550 new cases are estimated to be diagnosed in Paraiba and 210 in the capital of the state, which amounts to raw rates of 28.68/100,000 and 59.34/100,000, respectively(2).

Conducting studies in this context is relevant, especially studies producing evidence to fill in gaps of knowledge concerning the issue, specifically pregnancy-associated breast cancer (PABC), which is addressed in this study.

PABC is every breast cancer diagnosed during pregnancy or up to one year after birth. The first reports of this disease, date to more than a hundred years ago and had a poor prognosis. The first researchers published a case series and after five years of follow-up, all patients died(3).

A study published in 1999 indicated that breast cancer accounts for 0.2% to 3.8% of all cancers affecting women during pregnancy, with a ratio from 1/3,000 to 1/10,000 pregnancies(4). Another study reported that depending on the country, some case series presented an association of 1/2,000 pregnancies(5). PABC is the second most frequent cause of neoplasia associated with pregnancy, surpassed only by cervical cancer(4,6).

Over the course of our careers, we have developed activities with groups of women with cancer, including women who were undergoing treatment and became pregnant or who became pregnant after a cancer diagnosis and those who within five years due to the pathology. From this experience emerged the need to research the prognosis of PABC.

Given the preceding discussion, we believe this study provides support based on the results of studies that can help decision-making of nurses aiming to improve care provided to women with breast cancer.

 

Objective

To analyze evidence available in the literature on the prognosis of PABC.

 

Method

Evidence-based practice (EBP) involves the definition of a problem, the search for and critical evaluation of available evidence, implementation of evidence in practice and evaluation of the results obtained. The clinical expertise of professionals and patients’ preferences are aspects that are also incorporated into the EBP for decision-making concerning health care(7).

The method chosen to achieve the proposed objective in this study was an Integrative Review (IR), which considerably contributes to strengthening EBP.

The following stages were followed: identification of the theme or development of the guiding question, sampling or search of studies in the literature, categorization of studies, evaluation of studies included in the review, discussion and interpretation of results, and synthesis of knowledge found in the analyzed papers or the presentation of the integrative review’s results(8).

The guiding question used in this integrative review was: “What is the evidence available in the literature concerning the prognosis of PABC?”

The following databases were used to search for primary studies: PUBMED-MEDLINE (Medical Literature Analysis and Retrieval System on-line), CINAHL (Cumulative Index to Nursing and Allied Health Literature) and LILACS (Latin-American and Caribbean Health Sciences).

The controlled and non-controlled descriptors (key words) selected for the primary studies search are listed in Figure 1, which were combined and/or modified in each database according to the need to ensure a comprehensive search.

 

 

Inclusion criteria to select primary studies were: papers addressing breast cancer during pregnancy, published in English, Spanish or Portuguese in the last ten years (January 2000 up to April 2010). Literature reviews or narrative reviews and editorials were excluded.

Primary studies were selected by title and abstract according to the study’s objective and adopted inclusion and exclusion criteria. A total of 178 papers were pre-selected from PUBMED, 26 from LILACS, and 36 from CINAHL, totaling 240 papers.

A total of 26 papers were drawn from those primary studies pre-selected from PUBMED after a fresh reading, from which 17 were excluded. Hence, nine papers from this database were included in the review. Only two papers from the 26 pre-selected from LILACS were included. Six primary studies were identified in CINAHL but they were all excluded. Therefore, the IR sample was composed of 13 papers, which were fully analyzed.

A data collection instrument proposed and validated by Ursi(9) was used to extract data. Concepts proposed by researchers from the nursing field were used to analyze the studies’ design and level of evidence of the primary studies included in the review(10-11)..

The analysis and synthesis of the primary studies were performed in a descriptive form, allowing readers to evaluate the quality of evidence (level of evidence) available in the literature concerning the investigated theme, support decision-making in daily nursing care provided to patients with PABC and also identify gaps of knowledge for the development of future research.

 

Results

Ten out of the 13 papers included in the review were published in English, two in Portuguese and one in Spanish. Publications originated from many different countries and the Irish Medical Journal stood out with two papers.

In relation to papers’ level of evidence: seven primary studies presented level of evidence IV, that is, case-control studies; five studies presented level of evidence VI: one descriptive, two case series, one retrospective and a case study; one study presented level of evidence VII: expert opinion. Figure 2, 3 and 4 present an abstract of each paper included in the IR and Figure 5 presents the synthesis of primary studies concerning the investigated outcome (prognosis).

 

Discussion

From the synthesis of evidence of the primary studies included in the review concerning the prognosis of PABC, we stress that nine out of the 13 studies included indicate that a poor prognosis is associated to late stage tumors(13-15,16-17,20-23).

A previous study had already indicated that poor prognoses are related to the time between the breast cancer diagnosis and pregnancies preceding the diagnosis(25). One recent study also indicates that one of the issues that complicate the prognosis of breast cancer during pregnancy is a delayed diagnosis(26). Poor prognoses are partially explained by the tendency of pregnant women to be in more advanced stages of the disease at the time of the diagnosis. Still, that does not seem to be the only explanation since there is also a study indicating that the pregnancy itself is an independent factor for a worse prognosis(27).

A study published in 1999 reports that the survival of patients in the stages II or III was 75%, suggesting that with modern therapy and multidisciplinary help, the prognosis would not be so poor as once believed(4). On the other hand, in two studies included in the integrative review, the results did not show statistically significant difference concerning survival rate in a comparison between PABC women and the control group (non-pregnant women)(17-18).

The authors of another study claim that pregnancy hormones would be responsible for a worse prognosis. Pregnancy is characterized by a significant increase of estrogen, IGF-1, progesterone and prolactin, which in turn are closely related to the etiology of breast cancer and its development. These hormones promote the growth of tumor cells responsive to hormones(28).

It became clear in cell culture that the increase of hormone concentrations during pregnancy can increase the proliferation of cancer cells and tumor size. Another hypothesis that would explain the high mortality of pregnant women with breast cancer is that pregnancy hormones select tumors with a worse prognosis. But there are few studies addressing the topic(29-31).

An immunohistochemistry study conducted over more than 700 cases of breast cancer reported that tumors of women who had recently gave birth did not differ in size, staging or receptors of estrogen and HER2 but did present more progesterone receptor-negative, positive p53 and a greater histological degree. Hence, progesterone receptor-negative seems to be associated with a worse prognosis, in part because it is less sensitive to tamoxifen and also because it confers an invasive phenotype on the tumor cells in a model system. A greater expression of p53 in pregnant women with breast cancer is also consistent in the selection of more aggressive tumors during pregnancy(29).

There is evidence in the literature indicating that a pregnancy does not worsen the evolution of breast cancer, according to five primary studies included in the review(12,15,22-24). The authors report that the prognosis of PABC women does not seem to differ from that of non-pregnant women within the same age range and who are at the same disease stage. These results are corroborated by two other studies(32-33). Two studies in the review indicate a poor prognosis for breast cancer patients when associated with young age, stating that young women with breast cancer, pregnant or not, tend to have a worse prognosis(18,21).

One of the aspects that complicate the prognosis of PABC is a delayed diagnosis. In this context, one should take into account the physiological changes caused by the pregnancy in the mammary glands related to consistency and density, which may mask the disease’s signs and symptoms and hinder a precise interpretation of screening exams, delaying diagnosis and consequently reducing the rates of the survival of these women(26). It is common in professional practice to encounter painless lumps that can go unnoticed due to the breasts’ increased volume and engorgement. Hence, the nurses’ preparedness to perform physical assessments, especially of the breasts during prenatal care and postpartum, is a relevant element that can contribute to the early detection of PABC.

The studied problem may be a result of inappropriate care that presents gaps mainly in prenatal care. Quality and humanized prenatal and postpartum care is essential for the health of mother and child. For care to be qualified and humanized, one has to look at the health-disease continuum from a new perspective and understand the person in her totality of body and mind and also consider the social, economic, cultural and physical environment where she is inserted. Moreover, new bases should be established for the relationships of those involved in the production of health: health professionals, users and managers(34).

It is the role of nurses to implement integral and multidisciplinary care for women experiencing breast cancer during pregnancy, intensifying continuous and individualized evaluation during prenatal care, acknowledging the participation of women and families in decision-making concerning the treatment and maintenance of pregnancy, and considering ethical, religious, psychological, organic and legal aspects(35).

 

Conclusion

The synthesis of knowledge produced in this integrative review indicates there is evidence in the literature that a pregnancy does not worsen the evolution of breast cancer and that the poor diagnosis is related to the late stage tumors. However, given the reduced number of papers included in the analysis and their level of evidence (IV, VI and VII) further studies addressing the topic are needed.

The conduct of this integrative review reinforced the importance of early diagnosis, which can contribute to an improved prognosis for PABC women. In this context, we highlight the role of nurses since the results from this review support decision-making of nurses concerning the planning and implementation of interventions in nursing care provided to this population.

Nurses working with care delivered to women at all levels of care need to implement strategies to intensify preventive actions and the early detection of breast cancer, especially during pregnancy, and develop actions directed to primary care. The qualification of nurses to perform physical assessments, especially of breasts during prenatal and postpartum care, is a relevant contribution to the early detection of PABC.

Among the required actions, we highlight health education actions in which nurses should encourage an active role of women using the health services, stimulating breast self-examination. Nursing has a preponderant role in developing actions jointly with the population since the focus of its work is humanized care, centered on disease prevention of and health promotion.

Finally, among the gaps identified in the studied topic, we underscore the need to conduct studies addressing nursing care provided to PABC women in order to promote improved health care.

 

References

1. Fernandes AFC, Mamede MV. Câncer de mama: mulheres que sobreviveram. Fortaleza (CE): Universidade Federal do Ceará; 2003. 93 p.         [ Links ]

2. Brasil. Ministério da Saúde. Instituto Nacional de Câncer. Estimativa 2010: incidência de câncer no Brasil / Instituto Nacional de Câncer. Rio de Janeiro: INCA, 2009. 98p.         [ Links ]

3. Kilgore AR, Bloodgood JC. Tumors and tumor-like lesions of the breast in association with pregnancy. Arch Surg. 1929;18(5):2079-98.         [ Links ]

4. Berry DL, Theriaut RL, Holmes FA, Parisi VM, Booser DJ, Singletary SE, et al. Management of breast cancer during pregnancy using a standardized protocol. J Clin Oncol.1999;17(3):881-55.         [ Links ]

5. Gemignani M, Petrek J, Borgen P. Breast cancer and pregnancy. Surg Clin North Am. 1999; 79(5):1157-69.         [ Links ]

6. Brewster WR, Disaia PJ. Breast cancer associated whit pregnancy. In: Winchester DJ, Winchester DP, editors. Atlas of clinical oncology: breast cancer. London: Hamilton; 2000.p.258-259.         [ Links ]

7. Galvão CM, Sawada N, Rossi LA. A prática baseada em evidências: considerações teóricas para a sua implementação na enfermagem perioperatória. Rev Latino-am Enfermagem 2002;10(5):690-5.         [ Links ]

8. Mendes KD, Silveira RCCP, Galvão CM. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde na enfermagem. Texto Contexto Enferm. 2008;17(4):758-64.         [ Links ]

9. Ursi ES. Prevenção de lesão de pele no perioperatório: revisão integrativa da literatura. [dissertação de mestrado]. Ribeirão Preto (SP): Escola de Enfermagem de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto; 2005.128p.         [ Links ]

10. Polit DF, Beck CT, Hungler BP. Fundamentos de pesquisa em enfermagem: métodos, avaliação e utilização. 5. ed. Porto Alegre (RGS): Artmed, 2004. p.487        [ Links ]

11. Melnyk BM, Fineout-Overholt E. Making the case for evidence-based practice and cultivating a spirit of inquiry. In: Melnyk BM, Fineout-Overholt. Evidence-based practice in nursing & healthcare. A guide to best practice. Philadelphia: Wolters Kluwer, Lippincott Williams & Wilkins; 2011.p.3-24.         [ Links ]

12. Gelber S, Coates AS, Goldhirsch A, Castiglione-Gertsch M, Marini G, Lindtner J, et al. Effect of pregnancy on overall survival after the diagnosis of early-stage breast cancer. J Clin Oncol. 2001;19(6):1671-5.         [ Links ]

13. Mottola-Junior J, Berrettini-Junior A, Mazzoccato C, Laginha F, Fernandes CE, Marques JA. Câncer de mama associado à gravidez: um estudo caso/controle. Rev Bras Ginecol Obstet.2002;24(9):585-91.         [ Links ]

14. Reed W, Hannisdal E, Skovlund E, Thoresen S, Lilleng P, Nesland JM. Pregnancy and breast cancer: a population-based study. Virchows Arch. 2003;443(1):44-50.         [ Links ]

15. Aziz S, Kayani N, Israr M, Rahbar M, Pervez S, Khan S, et al. Case control study of novel prognostic markers and disease outcome in pregnancy/lactation-associated breast carcinoma. Pathol Res Pract.2003;199(1):15–21.         [ Links ]

16. Makgasa M, Prichard RS, Malone C, Kerin MJ. Pregnancy associated breast cancer. Ir Medical J. 2009;102(10):314-17.         [ Links ]

17. Halaska MJ, Pentheroudakis G, Strnad P, Stankusova H, Chod J, Robova HMD, et al. Presentation, management and outcome of 32 patients with pregnancy-associated Breast cancer: a matched controlled study. The Breast J. 2009;15(5):461–67.         [ Links ]

18. Beadle BM, Woodward WA, Middleton LP, Tereffe W, Strom EA, Litton JK, et al. The impact of pregnancy on breast cancer outcomes in women < 35 Years. Cancer 2009; 115(6):1174-84.         [ Links ]

19. Peralta Musre O. Cáncer de mama y embarazo. Rev Chil Obstet Ginecol.2001;66(1):68-73.         [ Links ]

20. Hill A, Dijkstra B, Healy CM, Kelly LM; Mcdermott EW, O’Higgins, N. Pregnancy-associated breast cancer. Ir Medical J. 2002;95(2):51-2, 54.         [ Links ]

21. Grossmann R, Zettler CG, Saccozzi R, Grossmann S. Avaliação dos fatores prognósticos e preditivos de associação no câncer mamário durante a gestação. Rev Bras Mastologia 2002; 12(2):23-7.         [ Links ]

22. Martínez-Ramos D, Ferraris C; Greco M, Grosso I, Conti AR. Carcinoma de mama durante el embarazo. Cir Esp.2007;82(5):305-7.         [ Links ]

23. Khairy GA, Al-Abdulkarim HA. Breast carcinoma during pregnancy. Saudi Med J. 2008;29(11):1662-65.         [ Links ]

24. Loibl S, Von Minckwitz G, Gwyn K, Ellis P, Blohmer JU; Schlegelberger B, et al. Breast carcinoma during pregnancy. International recommendations from an expert meeting. Cancer 2006;106(2):237-46.         [ Links ]

25. Von Schoultz E, Johansson H, Wilking N, Rutqvist LE. Influence of prior and subsequent pregnancy on breast cancer prognosis. J Clin Oncol. 1995;13(2):430-4.         [ Links ]

26. Lyons TR, Schedin PJ, Borges V. F. Pregnancy and breast cancer: when they collide. J Mammary Gland Biol Neoplasia 2009;14(2):87–98.         [ Links ]

27. Kettelhut JC, Modena MAB. Câncer de mama e gestação Rev Fac Ciênc Med.2008;10(4):1-4.         [ Links ]

28. Rossouw JE, Anderson GL, Prentice RL, Lacroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women´s Health Initiative randomized controlled trial. JAMA 2002;288(3):321-33.         [ Links ]

29. Daling JR, Malone KE, Doody DR, Anderson BO, Porter PL. The relation of productive factors to mortality from breast cancer. Cancer Epidemiol Biomarkers Prev. 2002;11(3):235-41.         [ Links ]

30. Jacobsen BM, Schittone SA, Richer JK, Horwitz KB. Progesterone-independent effects of human progesterone receptors in estrogen receptor-positive breast cancer. Mol Endocrinol.2005;19(3):574-84.         [ Links ]

31. Vousden K. P53 and prognosis: news insights and further complexity. Cell. 2005;120(1):7-10.         [ Links ]

32. Melinda A, Maggard MD, Jessica B, O’Connell MD, Karen E, Lane MD, et al. Do young breast cancer patients have worse outcomes? J Surgical Research 2003;113(1):109-13.         [ Links ]

33. Azad G K, Ring AE. Breast cancer and pregnancy. Breast Cancer Online 2007;10(10):1-5.         [ Links ]

34. Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Ações Programáticas Estratégicas. Área Técnica de Saúde da Mulher. Pré-natal e Puerpério: atenção qualificada e humanizada - Manual técnico. Brasília (DF): Ministério da Saúde, 2005. 158p.         [ Links ]

35. Lima AP, Teixeira RC, Corrêa ACP, Oliveira QC. Câncer de mama e de colo uterino no período gestacional: uma revisão de literatura. Ciênc Cuid Saúde 2009;8(4):699-706.         [ Links ]

 

 

Corresponding Author:
Cristina Maria Galvão
Universidade de São Paulo. Escola de Enfermagem de Ribeirão Preto
Departamento de Enfermagem Geral e Especializada
Av. dos Bandeirantes, 3900
Bairro: Monte Alegre
CEP: 14040-902, Ribeirão Preto, SP, Brasil
E-mail: crisgalv@eerp.usp.br

 

 

Received: Jan. 18th 2011
Accepted: Ago. 15th 2011

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