COMBINED HEART-LIVER-KIDNEY TRANSPLANTATION: THE FIRST EXPERIENCE IN LATIN AMERICA

TRANSPLANTE COMBINADO CORAÇÃO-FÍGADO-RIM: A PRIMEIRA EXPERIÊNCIA NA AMÉRICA LATINA

DESCRITORES:
Transplante Cardíaco; Transplante Hepático; Transplante Renal; Transplantes.

HEADINGS:
Heart Transplantation; Liver Transplantation; Kidney Transplantation; Transplants.

INTRODUCTION

Multiorgan dysfunction involving the liver and kidneys is common in patients with end-stage heart failure. The first combined liver-kidney transplant (CLKT) was performed by Margreiter in 1983, and it is a routine procedure in many transplant centers representing 1-8% of liver transplant candidates⁵.

Hepatic and renal dysfunction may be secondary to a systemic disease process affecting the heart, liver, and kidneys or may be a consequence of heart failure with venous congestion and arterial hypoperfusion^2,4.

Despite the complexity and costs involved, the results of this type of transplant are optimistic, as these are terminally ill patients.

Our objective was to report the first Latin American experience in triple transplantation in the same surgical time (heart, liver, and kidney), which took place at Hospital São Lucas Copacabana¹.

Case Report

The organ receiver was a 56-year-old male, physical education teacher, diagnosed with dilated cardiomyopathy with biventricular dysfunction of undetermined origin and compensated cirrhosis of probable cardiogenic etiology diagnosed in 2018 during a cholecystectomy. Chronic kidney disease was due to cardiorenal syndrome.

After follow-up of the case, triple liver-cardiac-renal transplantation was indicated.

The patient was registered in the national transplant system according to the MELD scale. He remained on the transplant waiting list for 17 days. An 18-year-old, a victim of polytrauma, donor was available. The organ harvesting took place on the same day (Figure 1).

Figure 1 -
Donor organs on the left and organs from the receiver to the right.

En bloc technique was used with a single piece consisting of the heart and liver and the kidneys were removed separately. The implant took place on April 5, 2022 and lasted for 8 h, with the heart implant performed by the cardiothoracic surgery team, and the liver and kidney implant performed by the abdominal surgery team (Figure 2).

Figure 2 -
Organs already implanted in the receiver.

The left femoral vein was cannulated and positioned below the renal veins, followed by cannulation of the superior vena cava and ascending aorta with subsequent initiation of cardiopulmonary bypass. For transplantation, the anterior diaphragm was opened up to the inferior vena cava with removal of the piece en bloc (heart plus liver) and subsequent insertion of the graft also en bloc. Later, a bicaval orthotopic heart transplant was performed.

For liver transplantation, hepatectomy was performed using the cross-clamp technique. The implantation took place with the completion of end-to-end anastomosis of the infrahepatic vena cava, end-to-end anastomosis of the portal vein, and end-to-end anastomosis of the hepatic artery.

Then, renal implantation was performed with end-to-side anastomoses of the renal vein of the donor’s right kidney with the recipient’s right common iliac vein. End-to-side anastomosis of the renal artery of the right kidney of the donor with the right internal iliac artery of the recipient was performed, followed by implantation of the ureter by the extravesical technique. After renal reperfusion, a bile duct anastomosis was performed.

The patient was referred to the ICU, where he remained for 6 days, and discharged after 11 days.

DISCUSSION

Combined heart-liver-kidney transplantation is quite rare, with few cases reported in the literature so far. Our case report represents the first transplant of its kind performed in Latin America. In this case, an atypical preparation was required involving different teams of surgeons, in addition to dozens of professionals responsible for logistics.

The en bloc technique was performed, in which the liver and heart remain connected by the inferior vena cava. It was possible to perform the cardiac and hepatic implant simultaneously. One of the benefits of this technique is that it allows the heart and liver to be perfused simultaneously, minimizing cold hepatic ischemia time. In addition, the patient is placed on cardiopulmonary bypass, which facilitates not only cardiac but also hepatic implantation, reducing the hemodynamic impact on the liver implant and assisting in blood oxygenation so that the grafts can later recover from the period of ischemia¹.

Ebong et al ² showed that the presence of advanced liver or kidney disease may increase the likelihood of complications and unfavorable outcomes after heart transplantation if liver and kidney transplantation are not performed concomitantly.

Another benefit associated with combined organ transplantation was evidenced by Ortega-Legaspi et al who showed immunological protection provided by a liver allograft from the same donor in cases of multiple organ transplantation^2,3,4.

The choice of the en bloc technique also reduces the surgical time as it reduces the number of anastomoses required. In our case, after the heart-liver implant, renal implantation was performed. This choice was made as a strategy if there was any intercurrence or instability during organ implantation. The renal graft allows longer ischemia times and could be implanted within 24 h, after hemodynamic stabilization of the patient, if necessary¹.

REFERENCES

• ¹
  Beal EW, Mumtaz K, Hayes D Jr, Whitson BA, Black SM. Combined heart-liver transplantation: Indications, outcomes and current experience. Transplant Rev (Orlando). 2016;30(4):261-8. doi: 10.1016/j.trre.2016.07.001. Epub 2016 Jul 17. PMID: 27527917; PMCID: PMC5450025.
  » https://doi.org/10.1016/j.trre.2016.07.001
• ²
  Ebong IA, Sayer G, Kim G, Jeevanandam V, Baker T, Becker Y, Fung J, Charlton M, Te H, Josephson M, Uriel N. Simultaneous heart, liver and kidney transplantation: A viable option for heart failure patients with multiorgan failure. J Heart Lung Transplant. 2019;38(9):997-999. doi: 10.1016/j.healun.2019.06.017. Epub 2019 Jun 19. PMID: 31495411; PMCID: PMC7039340.
  » https://doi.org/10.1016/j.healun.2019.06.017
• ³
  Ortega-Legaspi JM, Hoteit M, Wald J. Immune benefit of combined heart and liver transplantation. Curr Opin Organ Transplant. 2020;25(5):513-518. doi: 10.1097/MOT.0000000000000801. PMID: 32881718.
  » https://doi.org/10.1097/MOT.0000000000000801
• ⁴
  Torterolli F, Watanabe RK, Tabushi FI, Peixoto IL, Nassif PAN, Tefilli NL, Rocha SL, Malafaia O. BAR, SOFT and DRI post-hepatic transplantation: what is the best for survival analysis? Arq Bras Cir Dig. 2021;34(1):e1576. doi: 10.1590/0102-672020210001e1576. PMID: 34133523; PMCID: PMC8195467.
  » https://doi.org/10.1590/0102-672020210001e1576
• ⁵
  Veras FJ, Coelho GR, Feitosa-Neto BA, Cerqueira JB, Garcia RC, Garcia JH. Combined liver-kidney transplantation: experience at a Brazilian university hospital. Arq Bras Cir Dig. 2014 Jan-Mar;27(1):53-5. doi: 10.1590/s0102-67202014000100013. PMID: 24676300; PMCID: PMC4675492.
  » https://doi.org/10.1590/s0102-67202014000100013

• 1
  How to cite this article: Fernandes E, da Silva FR, Segalote R, Rocha PT, Mello F, Girão C, Oliveira R, Savattone L, César C, Siqueira M, Baamonde A, Tobias C, Oliveira G, Furtado R, Ribeiro T, Galhardo C, Mourad G, Robalinho F, Brito A. ABCD Arq Bras Cir Dig. 2022:35: e1668. https://doi.org/10.1590/0102-672020210002e1668

• Financial source: none.

Publication Dates

• Publication in this collection
  24 June 2022
• Date of issue
  2022

History

• Received
  18 Apr 2022
• Accepted
  19 Apr 2022