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Angiolymphatic invasion as a prognostic fator in resected N0 pancreatic adenocarcinoma

ABSTRACT

Background:

Pancreatic adenocarcinoma remains one of the worst digestive cancers. Surgical resection is the main target when treating a patient with curative intent.

Aim:

To assess angiolymphatic invasion as a prognostic factor in resected pN0 pancreatic cancer.

Methods:

Thirty-eight patients were submitted to pancreatoduodenectomy due to head pancreatic cancer. Tumor size, margins, lymph nodes, pTNM staging, angiolymphatic and perineural invasion were described in the pathologists' reports.

Results:

Most patients were female. Overall median survival was 13 months. Gemcitabine was the regimen of choice for chemotherapy in selected patients; however, it did not improve overall survival. pR0 resection had better survival compared with pR1. Within the pN0 group, survival was significantly better in patients without angiolymphatic invasion.

Conclusion:

Angiolymphatic invasion in N0 pancreatoduodenectomy can be demonstrated by the Hematoxylin-Eosin stain and may predict a poor prognosis factor for those patients.

HEADINGS -
Pancreatic neoplasms; Adenocarcinoma; Outcome assessment.

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