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The Krebs cycle as limiting factor for fatty acids utilization during aerobic exercise

Fatty acids are important fuels for muscle during moderate and prolonged exercise. The utilization of fatty acids by skeletal muscle depends on important key steps such as lipolysis in the adipose tissue, plasma fatty acids transport, and passage through plasma and mitochondrial membranes, beta-oxidation, and finally oxidation through the Krebs cycle and respiratory chain activity. Acute exercise and exercise training induce adaptations that lead to an increase in fatty acid oxidation. As a result muscle glycogen is preserved. Nevertheless, diet manipulation and supplementation with lipolytic agents that raise fatty acids mobilization and oxidation during exercise failed to show beneficial results on exercise performance. The hypothesis that Krebs cycle is a limiting factor for fatty acid oxidation by the skeletal muscle during prolonged exercise is presented herein.

Exercise; Fatty acid oxidation; Lipolytic agents; Krebs cycle; Glycogen

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