Clinical, sonographic, anatomic and physiological assessments of partial allotransplant urinary bladder with allogeneic mesenchymal stem cells derived from adipose tissue in rabbits

S. T. L. Pinto Filho M. T. Oliveira J. S. Aramburú Junior W. G. Glanzner T. O. Silva J. P. S. Feranti P. B. D. Gonçalves I. B. M. Cruz M. V. Brun N. L. Pippi About the authors

ABSTRACT

The problems related to bladder storage are many and significant. In addition to effectively impacting the quality of life, they can eventually progress to kidney failure. There are several studies which describe the immunomodulatory and immunosuppressive properties of ADSCs. The aim of this study is to clinically, through sonography, anatomically and physiologically evaluate fresh partial allograft bladder from rabbits using allogeneic ADSCs as immunomodulator agents. For such, 25 rabbits were used, one being a male ADSCs donor, and the other 24 females who underwent simultaneous partial allograft bladder, being treated with cyclosporine (GCi) or mesenchymal stem cells (GCe). It was concluded that ADSCs were sufficient to prevent clinical and ultrasound signs of allograft rejection of the urinary bladder. These bladders retained the anatomophysiological structure for 30 days in rabbits.

bladder; ADSC; surgery; graft


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