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Laboratory identification of the most frequent ocular pathogens and their in vitro sensitivity to antibiotics

Purpose: To establish the most frequently isolated agents in keratitis, conjunctivitis and endophthalmitis by the Laboratory of Microbiology/ Santa Casa of São Paulo, and to determine their antimicrobial sensitivity. Methods: A retrospective study including all ophthalmologic charts of the Laboratory of Microbiology/ Santa Casa of São Paulo was conducted. All ocular material collected during the last five years was analyzed. We included in this study only patients whose diagnoses were conjunctivitis, keratitis and endophthalmitis. Susceptibility tests of drugs with ophthalmological application were analyzed. Results: In a total of 568 cases, we found 282 of bacterial keratitis (49.6%), 214 of conjunctivitis (37.7%) and 72 of endophthalmitis (12.7%); three hundred thirty-three negative culture cases were found (58.9%). S. aureus was the most frequently isolated agent (n=73; 31.0%). Conjunctivitis showed Candida sp in 6.6% of all cases, and 38.3% of the cultures were negative. When the diagnosis was keratitis, P. aeruginosa was positive in 3.9% and 71.6% of the cultures were negative. Endophthalmitis showed only 32% of positivity. Conclusion: Inconclusive cultures were the majority. Facing an ocular infection, there is a considerable chance to find S. aureus.

Eye infections; Microbial sensitivity tests; Conjuntivitis bacterial; Keratitis; Endophthalmitis; Drug resistance

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