Critical analysis and systematization of rat pancreatectomy terminology

It was performed a review of indexed manuscripts in PUBMED from 01/01/1945 to 31/12/2015 with the combined keywords "rat pancreatectomy" and "rat pancreas resection". The following parameters was considered: A. Frequency of publications; B. Purpose of the pancreatectomy in each article; C. Bibliographic references; D. Nomenclature of techniques according to the pancreatic parenchyma resection percentage

RESULTS:

Among the 468, the main objectives were to surgically induce diabetes and to study the genes regulations and expressions. Five rat pancreatectomy technique references received 15 or more citations. Twenty different terminologies were identified for the pancreas resection: according to the resected parenchyma percentage (30 to 95%); to the procedure type (total, subtotal and partial); or based on the selected anatomical region (distal, longitudinal and segmental). A nomenclature systematization was gathered by cross-checking information between the main surgical techniques, the anatomic parameters descriptions and the resected parenchyma percentages.

CONCLUSION:

The subtotal pancreatectomy nomenclature for parenchymal resection between 80 and 95% establishes a surgical parameter that also defines the total and partial pancreatectomy limits and standardizes these surgical procedures in rats.

Key words:
Pancreatectomy; Systematized Nomenclature of Medicine; Anatomy; Rats

Purpose of the pancreatectomy	n
Diabetes mellitus induction	86
Expression and/or gene regulation study	29
Post-pancreatectomy metabolic effects	26
Pancreatic regeneration	12
Cell regeneration	11
β cells adaptation study	6
Hormonal action	5
Isolate pancreatic islets	5
Cell proliferation	5
Non-pancreatic organs effects	4
Drug action	2
Pancreatic cancer study	2
Pancreatic function	2
Insulin resistance	2
Intestinal absorption	1
Pancreatectomy description/study technique	1

Terms Found	n
Pancreatectomy 30%	2
Pancreatectomy 40%	1
Pancreatectomy 45%	1
Pancreatectomy 50%	18
Pancreatectomy 60%	29
Pancreatectomy 60-70%	2
Pancreatectomy 70%	19
Pancreatectomy 70-80%	1
Pancreatectomy 80%	8
Pancreatectomy 85%	3
Pancreatectomy 85-95%	3
Pancreatectomy 90%	150
Pancreatectomy 90-95%	2
Pancreatectomy 95%	25

Longitudinal Pancreatectomy	1
Partial Pancreatectomy	54
Segmental Pancreatectomy	1
Distal Pancreatectomy	1
Subtotal Pancreatectomy	2
Total Pancreatectomy	49

Pancreatectomy (unspecified)	96

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia https://actacirbras.com.br/ - São Paulo - SP - Brazil
E-mail: actacirbras@gmail.com

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[1] Correspondence: José Marcus Raso Eulálio Centro de Cirurgia Experimental Faculdade de Medicina-UFRJ Centro de Ciências da Saúde, Bloco J/2º andar 21941-559 Rio de Janeiro - RJ Brasil josemre@hucff.ufrj.br

	Year	Technical description	Other basic reference quote	Proposed technical changes	Resected parenchyma percentage	Lineage	Rat average weight	Rat gender	Number of citations (n = 158)
Foglia ²2 Foglia VG. Caracteristicas de la diabetes en la rata. Rev Soc Argent Biol. 1944;20:21-37.	1944	Yes	Yes	Yes	95%	Unspecified	Unspecified	Male	27
Skow ³3 Scow RO. Total pancreatectomy in the rat: operation, effects, and postoperative care. Endocrinology. 1957;60(3):359-67. doi: 10.1210/endo-60-3-359. https://doi.org/10.1210/endo-60-3-359...	1957	Yes	Yes	Yes	95% e 99,5%	Unspecified	110-150g	Female	15
Bonner-Weir ⁴4 Bonner-Weir S, Trent DF, Weir, GC. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest. 1983;71:1544-53. doi: 10.1172/JCI110910. https://doi.org/10.1172/JCI110910...	1983	Yes	Yes	No	90%	Sprague-Dawley	90-110g	Male	52
Bonner-Weir ⁵5 Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE. A second pathway for regeneration of adult exocrine and endocrine pancreas: a possible recapitulation of embryonic development. Diabetes. 1993;42(12):1715-20. doi: 10.2337/diab.42.12.1715. https://doi.org/10.2337/diab.42.12.1715...	1993	Yes	Yes	No	90%	Sprague-Dawley	95-125g	Male	34
Hosokawa ⁶6 Hosokawa YA, Hosokawa H, Chen C, Leahy JL. Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagonlike peptide-1. J Clin Invest. 1996;97(1):180-6. doi: 10.1172/JCI118387. https://doi.org/10.1172/JCI118387...	1996	Yes	Yes	No	90%	Sprague-Dawley	100g	Male	30

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Critical analysis and systematization of rat pancreatectomy terminology1 1 Research performed at Center of Experimental Surgical, Department of Surgery, School of Medicine, Universidade Federal do Rio de Janeiro (UFRJ), Brazil.

ABSTRACT

PURPOSE:

METHODS:

RESULTS:

CONCLUSION:

Critical analysis and systematization of rat pancreatectomy terminology^¹ 1 Research performed at Center of Experimental Surgical, Department of Surgery, School of Medicine, Universidade Federal do Rio de Janeiro (UFRJ), Brazil.