Nullity of GSTT1/GSTM1 related to pesticides is associated with Parkinson's disease

Nulidade de GSTT1/GSTM1 relacionada à pesticidas associa-se com doença de Parkinson

Marcela Augusta de Souza Pinhel Caroline Leiko Sado Gabriela dos Santos Longo Michele Lima Gregório Gisele Sousa Amorim Greiciane Maria da Silva Florim Camila Montoro Mazeti Denise Poltronieri Martins Fábio de Nazaré Oliveira Marcelo Arruda Nakazone Waldir Antonio Tognola Dorotéia Rossi Silva Souza About the authors

Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variants were analyzed by polymerase chain reaction. We applied the Fisher's exact test and the χ22. Korff A, Pfeiffer B, Smeyne M, et al. Alterations in glutathione S-transferase pi expression following exposure to MPP+-induced oxidative stress in the blood of Parkinson's disease patients. Parkinsonism Relat Disord 2011;17:765-768. test for statistical analysis (p<0.05). The present and absence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1 and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared to controls (13%, p=0.014). This study suggests the association between PD and previous exposure to pesticides, whose effect may be enhanced in combination with null for GSTT1/GSTM1.

Parkinson disease; glutathione transferase; polymorphism genetic; xenobiotics

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