Subpopulações linfocitarias do liquido cefalorraqueano normal: I. principais registros da literatura

Machado, L. R.

doi:10.1590/S0004-282X1983000200001

Resumos

São revistos os dados principais da literatura referentes ao perfil linfocitário no líquido cefalorraqueano. É dada atenção particular àqueles que dizem respeito às subpopulações T e B e aos contingentes T efetivamente mobilizados na produção e regulação da resposta imune no sistema nervoso central.

Data concerning the characterization of lymphocytes in the cerebrospinal fluid are reviewed, markedly those on T and B subpopulations. Special attention is given to T-lymphocyte subpopulations actually related to the immune response and to the immune regulation within the central nervous system.

Subpopulações linfocitarias do liquido cefalorraqueano normal: I. Principais registros da literatura

Lymphocyte sub populations in the cerebrospinal fluid: I - Literature

L. R. Machado

Médico-assistente. Centro de Investigações em Neurologia da Clínica Neurológica da Faculdade de Medicina da Universidade de São Paulo

RESUMO

São revistos os dados principais da literatura referentes ao perfil linfocitário no líquido cefalorraqueano. É dada atenção particular àqueles que dizem respeito às subpopulações T e B e aos contingentes T efetivamente mobilizados na produção e regulação da resposta imune no sistema nervoso central.

SUMMARY

Data concerning the characterization of lymphocytes in the cerebrospinal fluid are reviewed, markedly those on T and B subpopulations. Special attention is given to T-lymphocyte subpopulations actually related to the immune response and to the immune regulation within the central nervous system.

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Trabalho (Dissertação de Mestrado: primeira parte) do Centro de Investigações em Neurologia da Clínica Neurológica da Faculdade de Medicina da Universidade de São Paulo.

Centro de Investigações em Neurologia - Caixa Postal 5199 - 01000 São Paulo, SP - Brasil.

1. AISENBERG, A. C. & BLOCH, K. J. - Immunoglobulins on the surface of neoplastic lymphocytes. New Engl. J. Med. 287:272, 1972.
2. ALLEN, J. C.; SHEREMATA, W.; COSGROVE, J. B. R.; OSTERLAND, K. & SHEA, M. - Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis. Neurology (Minneapolis) 26:579, 1976.
3. ANDERSSON, L. C; NORDLING, S. & HÄYRY, P. - Fractionation of mouse T and B lymphocytes by preparative, cell electrophoresis. Cell. Immunol. 8:235, 1973.
4. BACH, J. F. - Evaluation of T-cells and thymic serum factors in man using the rosette technique. Transplant. Rev. 16:196, 1973.
5. BACH, J. F. - B and T lymphocytes. In Bach, J. F., ed. - Immunology. John Wiley & Sons, New York, 1978, pg. 57-91.
6. BACH, J. F. & REYES, F. - Lymphoid cells. In Bach, J. F., ed. - Immunology. John Wiley & Sons, New York, 1978, pg. 37-56.
7. BROSNAN, C, F.; STONER, G. L.; BLOOM, B. R. & WISNIEWSKI, H. M. - Studies on demyelination by activated lymphocytes in the rabbit eye: Antibody-dependent cell-mediated demyelination. J. Immunol. 118:2103, 1977.
8. BROUET, J. C. & PRIEUR, A. M. - Membrane markers on chronic lymphocytic leukemia with rosette due to anti-sheep erythrocytes antibody activity of the membrane bound IgM and a T cell leukemia with surface Ig. Clin. Immunol. Immunopath, 2:481, 1974.
9. CASPARY, E. A. & FIELD, E. J. - Lymphocyte sensitization to basic protein of brain in multiple sclerosis and other neurological diseases. J. Neurol. Neurosurg. Psychiat. (London) 37:701, 1974.
10. CATOVSKY, D. & ENNO, A. - Morphological and cytochemical identification of lymphoid cells. Lymphology 10:77, 1977.
11. CATOVSKY, D.; PAPAMICHAIL, M.; OKOS, A.; MILIANI, E. & HOLBOROW, E. J. - Formation of mouse red cell rosettes by «hairy» cells. Biomedicine 23:81, 1975.
12. COOK, J. D. & BROOKS, B. R. - Lymphocyte subpopulations in human cerebrospinal fluid. In Wood, J. H., ed. - Neurobiology of Cerebrospinal Fluid-1. Plenum Press, New York, 1980, pg. 507-523.
13. COOMBS, R. R. A.; FEINSTEIN, A. & WILSON, A. B. - Immunoglobulin determinants on the surface of human lymphocytes. Lancet 2:1157, 1969.
14. COOMBS, R. R. A.; GURNER, B. W.; WILSON, A. B.; HOLM, G. & LINDGREN, B. - Rosette-formation between human lymphocytes and sheep red cells not involving immunoglobulin receptors. Int. Arch. Allergy 39:658, 1970.
15. CZLONKOWSKA, A.; PÓLTORAK, M.; CENDROWSKI, W. & KORLAK, J. - Lymphocyte subpopulations in the cerebrospinal fluid and peripheral blood in multiple sclerosis. Acta, neurol. scand. 62:55, 1980.
16. DISTELHORST, C. W. & BENUTTO, B. M. - Glucocorticoid receptor content of T lymphocytes: evidence for heterogeneity. J. Immunol. 126:1630, 1981.
17. DJEU, J.; PAYNE, S.; ALFORD, C; HEIM, W.; POMEROY, T.; COHEN, M.; OLDHAM, R. & HERBERMAN, R. B. - Detection of decreased proportion of lymphocytes farming rosettes with sheep erythrocytes at 29oC in the blood of cancer patients. Clin. Immunol. Immunopath. 8:405, 1977.
18. DJEU, J. Y.; HEINBAUGH, J. A.; HOLDEN, H. T. & HERBERMAN, R. B. - Role of macrophages in the augmentation of mouse natural killer cell activity by poly I : C and interferon. J. Immunol. 122:182, 1979.
19. EDEN, A.; MILLER, G. W. & NUSSENZWEIG, V. - Human lymphocytes bear membrane receptors for C b and C₃d. J. clin. Invest. 52:3239, 1973.
20. EL-NAGGAR, A. & HIGASHI, G. I. - Tuberculous meningitis: E-rosette-forming T lymphocytes in cerebrospinal fluid. Neurology (New York) 31:610, 1981.
21. FELSBURG, P. J. & EDELMAN, R. - The active E-rosette test: a sensitive in vitro correlate for human delayed-type hypersensitivity. J. Immunol. 118:62, 1977.
22. FELSBURG, P. J.; EDELMAN, R. & GILMAN, R. H. - The active E-rosette test. Correlation with delayed cutaneous hypersensitivity. J. Immunol. 116:1110, 1976.
23. FERRARINI, M.; MCRETTA, L.; ABRILE, R. & DURANTE, M. L. - Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells. Eur. J. Immunol. 5:70, 1975.
24. FLOREY, M. J. & PEETOOM, F. - Modified E-rosette test for detection of total and active rosette-forming lymphocytes. J. Immunol. Methods 13:201, 1976.
25. FORD, W. L. - Lymphocyte migration and immune responses. Prog. Allergy 19:1-59, 1975.
26. FORD, W. L. - The preparation and labelling of lymphocytes. In Weir, D. M., ed. - Handbook of Experimental Immunology, ed. 3. Blackwell Scientific Publications, Oxford, 1978, pg. 23.1-23.22.
27. FRYDÊN, A.; KAM-HANSEN, S.; MALLER, R. & LINK, H. - Active and total T cells in blood and cerebrospinal fluid during the course of aseptic meningitis. Acta neurol. scand. 61:306, 1980.
28. FRYDÊN, A. & LINK, H. - Mitogen stimulation of cerebrospinal fluid lymphocytes in aseptic meningitis. Acta neurol. scand. 57:8, 1978.
29. FRYDÉN, A.; LINK, H. & MÖLLER, E. - Demonstration of cerebrospinal fluid lymphocytes sensitized against virus antigens of mumps meningitis. Acta neurol. scand. 57:396, 1978.
30. FROLAND, S. S.; NATVIG, J. B. & MICHAELSEN, T. E. - Binding of aggregated IgG by human B lymphocytes independent of Fc receptors. Scand. J. Immunol. 3:375, 1974.
31. GALTON, J. & IVANYI, J. - An immunofluorescent technique for the detection of lymphocyte alloantigens. J. Immunol. Methods 17:57, 1977.
32. GHETIE, V.: MEDESAN, C. & SJÖQUIST, J. - A method for the detection and quantitation of Fc receptor sites on cells. Scand. J. Immunol. 5:1199, 1976.
33. GOASGUEN, J. & SABOURAUD, O. - Rosettes mouton sur lymphocytes de liquide céphalorachidien. Nouv. Presse méd. 35:2266, 1974.
34. GOUST, J. M.; CHENAIS, F.; CARNES, J. E.; HAMES, C. G.; FUDENBERG, H. H. & HOGAN, E. L. - Abnormal T cell subpopulations and circulating immune complexes in the Guillain-Barré syndrome and multiple sclerosis. Neurology (Minneapolis) 28:421, 1978.
35. GREAVES, M. F. & BROWN, G. - A human B lymphocytes specific antigen. Nature (London) 246:116, 1973.
36. HEBERMAN, R. R., ORTALDO, J. R. & BONNARD, G. D. - Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity. Nature (London) 277:221, 1979.
37. HOKLAND, P. & HERON, I. - Functional characterization in vitro of two human T-cell subpopulations with different affinities to sheep erythrocytes. Scand. J. Immunol. 9:333, 1979.
38. HOLBOROW, E. J. & PAPAMICHAIL, M. - Observation on lymphocytes bearing surface immunoglobulin in health and in disease. Int. Arch. Allergy 45:210, 1973.
39. HOLBOROW, E. J. & REEVES, W. G. - The lymphoid system. In Holborow, E. J. & Reeves, W. G., eds. - Immunology in Medicine. Academic Press, London; Grune & Stratton, New York, 1977, pg. 27-48.
40. HUDDLESTONE, J. R. & OLDSTONE, M. B. A. - T suppressor (T_G) lymphocytes fluctuate in parallel with changes in the clinical course of patients with multiple sclerosis. J. Immunol. 123:1615, 1979.
41. IMIR, T.; SAKSELA, E. & MÄKELÄ, O. - Two types of antibody dependent cell-mediated cytotoxicity arming and sensitization. J. Immunol. 117:1938, 1976.
42. JANEWAY Jr., C. A.; WIGZELL, H. & BINZ, H. - Two different Vh gene products make up the T-cell receptors. Scand. J. Immunol. 5:993, 1976.
43. JONDAL, M.; HOLM, G. & WIGZELL, H. - Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J. exp. Med. 136:207, 1972.
44. JONDAL, M.; WIGZELL, H. & AIUTI, F. - Human lymphocyte subpopulations: classification according to surface markers and/or functional characteristics. Transplant. Rev. 16:163, 1973.
45. KAFT, D. - Characteristics and clinical importance of killer (K)-cells. British J. Derm. 95:449, 1976.
46. KAM-HANSEN, S. - Reduced number of active T cells in cerebrospinal fluid in multiple sclerosis. Neurology (Minneapolis) 29:897-899, 1979.
47. KAM-HANSEN, S. - Distribution and function of lymphocytes from the cerebrospinal fluid and blood in patients with multiple sclerosis. Acta neurol. scand. 62 (suppl. 75):1-81. 1980.
48. KAM-HANSEN, S.; FRYDÊN, A. & LINK, H. - B and T lymphocytes in cerebrospinal fluid and blood in multiple sclerosis, optic neuritis and mumps meningitis. Acta neurol. scand. 58:95, 1978.
49. KAM-HANSEN, S.; ROSTROM, B. & LINK, H. - Active T cells and humoral immune variables in blood and cerebrospinal fluid in patients after acute unilateral idiopathic optic neuritis. Acta neurol. scand. 61:298, 1980.
50. KASCHKA, W. P. & HILGERS, R. - Blood lymphocyte subpopulation show characteristic changes during ACTH therapy in acute exacerbations of multiple sclerosis. Acta neurol. scand. 61:275, 1980.
51. KATELEY, J. R. & BAZZELL, S. J. - Immunological dysfunctions in multiple sclerosis. Diminuition of «active» thymus-derived lymphocytes and presence of immunomodulating serum factors. Clin. exp. Immunol. 35:218, 1979.
52. KERSEY, J. H. & GAJL-PECZALSKA, K. J. - T and B lymphocytes in humans: a review. Amer. J. Path: 81:446, 1975.
53. KRETH, H. W. & WIEGAND, G. - Cell-mediated cytotoxicity against measles virus in SSPE. J. Immunol. 118:296, 1977.
54. LISAK, R. P.; LEVINSON, A. I.; ZWEIMAN, B. & ABDOU, N. I. - T and B lymphocytes in multiple sclerosis. Clin. exp. Immunol. 22:30, 1975.
55. LISAK, R. P.; ZWEIMAN, B.; WATERS, D.; KOPROWSKI, H. & PLEASURE, D. E. - Cell-mediated immunity to measles, myelin basic protein, and central nervous system extract in multiple sclerosis. Neurology (Minneapolis) 28:798, 1978.
56. LISAK, R. P.; ZWEIMAN, B. & WHITAKER, J. N. - Spinal fluid basic protein immunoreactive material and spinal fluid lymphocyte reactivity to basic protein. Neurology (New York) 31:180, 1981.
57. MANCONI, P. E.; MARROSU, M. G.; CIANCHETTI, C; ENNAS, M. G.; MANGONI, A. & ZACCHEO, D. - Lymphocyte subpopulations in cerebrospinal fluid and peripheral blood in multiple sclerosis. Acta neurol. scand. 62:165, 1980.
58. MANCONI, P. E.; ZACCHEO, D.; BUGIANI, O.; FADDA, M. F.; CADONI, A.; MARROSU, M. G.; CIANCHETTI, C. & GRIFONI, V. - Surface markers on lymphocytes from human cerebrospinal fluid. Predominance of T lymphocytes bearing receptor for the Fc segment of IgG. Eur. Neurol. 17:87, 1978.
59. MANCONI, P. E.; ZACCHEO, D.; BUGIANI, O.; FADDA, M. F.; GRIFONI, J.; MANTOVANI, G.; GIACCO, G. S. & TOGNELLA, S. - T and B lymphocytes in normal cerebrospinal fluid. New Engl. J. Med. 294:49, 1976.
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64. NILSSON, O. & THELIN, C. - Cellular immunity to encephalitogenic protein in multiple sclerosis: correlations with other laboratory characteristics at different disease courses. Eur. Neurol. 16:247, 1977.
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Datas de Publicação

Publicação nesta coleção
14 Ago 2012
Data do Fascículo
Jun 1983

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. AISENBERG, A. C. & BLOCH, K. J. - Immunoglobulins on the surface of neoplastic lymphocytes. New Engl. J. Med. 287:272, 1972.

[2] 2. ALLEN, J. C.; SHEREMATA, W.; COSGROVE, J. B. R.; OSTERLAND, K. & SHEA, M. - Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis. Neurology (Minneapolis) 26:579, 1976.

[3] 3. ANDERSSON, L. C; NORDLING, S. & HÄYRY, P. - Fractionation of mouse T and B lymphocytes by preparative, cell electrophoresis. Cell. Immunol. 8:235, 1973.

[4] 4. BACH, J. F. - Evaluation of T-cells and thymic serum factors in man using the rosette technique. Transplant. Rev. 16:196, 1973.

[5] 5. BACH, J. F. - B and T lymphocytes. In Bach, J. F., ed. - Immunology. John Wiley & Sons, New York, 1978, pg. 57-91.

[6] 6. BACH, J. F. & REYES, F. - Lymphoid cells. In Bach, J. F., ed. - Immunology. John Wiley & Sons, New York, 1978, pg. 37-56.

[7] 7. BROSNAN, C, F.; STONER, G. L.; BLOOM, B. R. & WISNIEWSKI, H. M. - Studies on demyelination by activated lymphocytes in the rabbit eye: Antibody-dependent cell-mediated demyelination. J. Immunol. 118:2103, 1977.

[8] 8. BROUET, J. C. & PRIEUR, A. M. - Membrane markers on chronic lymphocytic leukemia with rosette due to anti-sheep erythrocytes antibody activity of the membrane bound IgM and a T cell leukemia with surface Ig. Clin. Immunol. Immunopath, 2:481, 1974.

[9] 9. CASPARY, E. A. & FIELD, E. J. - Lymphocyte sensitization to basic protein of brain in multiple sclerosis and other neurological diseases. J. Neurol. Neurosurg. Psychiat. (London) 37:701, 1974.

[10] 10. CATOVSKY, D. & ENNO, A. - Morphological and cytochemical identification of lymphoid cells. Lymphology 10:77, 1977.

[11] 11. CATOVSKY, D.; PAPAMICHAIL, M.; OKOS, A.; MILIANI, E. & HOLBOROW, E. J. - Formation of mouse red cell rosettes by «hairy» cells. Biomedicine 23:81, 1975.

[12] 12. COOK, J. D. & BROOKS, B. R. - Lymphocyte subpopulations in human cerebrospinal fluid. In Wood, J. H., ed. - Neurobiology of Cerebrospinal Fluid-1. Plenum Press, New York, 1980, pg. 507-523.

[13] 13. COOMBS, R. R. A.; FEINSTEIN, A. & WILSON, A. B. - Immunoglobulin determinants on the surface of human lymphocytes. Lancet 2:1157, 1969.

[14] 14. COOMBS, R. R. A.; GURNER, B. W.; WILSON, A. B.; HOLM, G. & LINDGREN, B. - Rosette-formation between human lymphocytes and sheep red cells not involving immunoglobulin receptors. Int. Arch. Allergy 39:658, 1970.

[15] 15. CZLONKOWSKA, A.; PÓLTORAK, M.; CENDROWSKI, W. & KORLAK, J. - Lymphocyte subpopulations in the cerebrospinal fluid and peripheral blood in multiple sclerosis. Acta, neurol. scand. 62:55, 1980.

[16] 16. DISTELHORST, C. W. & BENUTTO, B. M. - Glucocorticoid receptor content of T lymphocytes: evidence for heterogeneity. J. Immunol. 126:1630, 1981.

[17] 17. DJEU, J.; PAYNE, S.; ALFORD, C; HEIM, W.; POMEROY, T.; COHEN, M.; OLDHAM, R. & HERBERMAN, R. B. - Detection of decreased proportion of lymphocytes farming rosettes with sheep erythrocytes at 29oC in the blood of cancer patients. Clin. Immunol. Immunopath. 8:405, 1977.

[18] 18. DJEU, J. Y.; HEINBAUGH, J. A.; HOLDEN, H. T. & HERBERMAN, R. B. - Role of macrophages in the augmentation of mouse natural killer cell activity by poly I : C and interferon. J. Immunol. 122:182, 1979.

[19] 19. EDEN, A.; MILLER, G. W. & NUSSENZWEIG, V. - Human lymphocytes bear membrane receptors for C b and C₃d. J. clin. Invest. 52:3239, 1973.

[20] 20. EL-NAGGAR, A. & HIGASHI, G. I. - Tuberculous meningitis: E-rosette-forming T lymphocytes in cerebrospinal fluid. Neurology (New York) 31:610, 1981.

[21] 21. FELSBURG, P. J. & EDELMAN, R. - The active E-rosette test: a sensitive in vitro correlate for human delayed-type hypersensitivity. J. Immunol. 118:62, 1977.

[22] 22. FELSBURG, P. J.; EDELMAN, R. & GILMAN, R. H. - The active E-rosette test. Correlation with delayed cutaneous hypersensitivity. J. Immunol. 116:1110, 1976.

[23] 23. FERRARINI, M.; MCRETTA, L.; ABRILE, R. & DURANTE, M. L. - Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells. Eur. J. Immunol. 5:70, 1975.

[24] 24. FLOREY, M. J. & PEETOOM, F. - Modified E-rosette test for detection of total and active rosette-forming lymphocytes. J. Immunol. Methods 13:201, 1976.

[25] 25. FORD, W. L. - Lymphocyte migration and immune responses. Prog. Allergy 19:1-59, 1975.

[26] 26. FORD, W. L. - The preparation and labelling of lymphocytes. In Weir, D. M., ed. - Handbook of Experimental Immunology, ed. 3. Blackwell Scientific Publications, Oxford, 1978, pg. 23.1-23.22.

[27] 27. FRYDÊN, A.; KAM-HANSEN, S.; MALLER, R. & LINK, H. - Active and total T cells in blood and cerebrospinal fluid during the course of aseptic meningitis. Acta neurol. scand. 61:306, 1980.

[28] 28. FRYDÊN, A. & LINK, H. - Mitogen stimulation of cerebrospinal fluid lymphocytes in aseptic meningitis. Acta neurol. scand. 57:8, 1978.

[29] 29. FRYDÉN, A.; LINK, H. & MÖLLER, E. - Demonstration of cerebrospinal fluid lymphocytes sensitized against virus antigens of mumps meningitis. Acta neurol. scand. 57:396, 1978.

[30] 30. FROLAND, S. S.; NATVIG, J. B. & MICHAELSEN, T. E. - Binding of aggregated IgG by human B lymphocytes independent of Fc receptors. Scand. J. Immunol. 3:375, 1974.

[31] 31. GALTON, J. & IVANYI, J. - An immunofluorescent technique for the detection of lymphocyte alloantigens. J. Immunol. Methods 17:57, 1977.

[32] 32. GHETIE, V.: MEDESAN, C. & SJÖQUIST, J. - A method for the detection and quantitation of Fc receptor sites on cells. Scand. J. Immunol. 5:1199, 1976.

[33] 33. GOASGUEN, J. & SABOURAUD, O. - Rosettes mouton sur lymphocytes de liquide céphalorachidien. Nouv. Presse méd. 35:2266, 1974.

[34] 34. GOUST, J. M.; CHENAIS, F.; CARNES, J. E.; HAMES, C. G.; FUDENBERG, H. H. & HOGAN, E. L. - Abnormal T cell subpopulations and circulating immune complexes in the Guillain-Barré syndrome and multiple sclerosis. Neurology (Minneapolis) 28:421, 1978.

[35] 35. GREAVES, M. F. & BROWN, G. - A human B lymphocytes specific antigen. Nature (London) 246:116, 1973.

[36] 36. HEBERMAN, R. R., ORTALDO, J. R. & BONNARD, G. D. - Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity. Nature (London) 277:221, 1979.

[37] 37. HOKLAND, P. & HERON, I. - Functional characterization in vitro of two human T-cell subpopulations with different affinities to sheep erythrocytes. Scand. J. Immunol. 9:333, 1979.

[38] 38. HOLBOROW, E. J. & PAPAMICHAIL, M. - Observation on lymphocytes bearing surface immunoglobulin in health and in disease. Int. Arch. Allergy 45:210, 1973.

[39] 39. HOLBOROW, E. J. & REEVES, W. G. - The lymphoid system. In Holborow, E. J. & Reeves, W. G., eds. - Immunology in Medicine. Academic Press, London; Grune & Stratton, New York, 1977, pg. 27-48.

[40] 40. HUDDLESTONE, J. R. & OLDSTONE, M. B. A. - T suppressor (T_G) lymphocytes fluctuate in parallel with changes in the clinical course of patients with multiple sclerosis. J. Immunol. 123:1615, 1979.

[41] 41. IMIR, T.; SAKSELA, E. & MÄKELÄ, O. - Two types of antibody dependent cell-mediated cytotoxicity arming and sensitization. J. Immunol. 117:1938, 1976.

[42] 42. JANEWAY Jr., C. A.; WIGZELL, H. & BINZ, H. - Two different Vh gene products make up the T-cell receptors. Scand. J. Immunol. 5:993, 1976.

[43] 43. JONDAL, M.; HOLM, G. & WIGZELL, H. - Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J. exp. Med. 136:207, 1972.

[44] 44. JONDAL, M.; WIGZELL, H. & AIUTI, F. - Human lymphocyte subpopulations: classification according to surface markers and/or functional characteristics. Transplant. Rev. 16:163, 1973.

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Subpopulações linfocitarias do liquido cefalorraqueano normal: I. principais registros da literatura

Lymphocyte sub populations in the cerebrospinal fluid: I - literature

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