Comparative study of HDL and LDL cholesterol as risk factors for carotid atherosclerosis

Rubens José Gagliardi Marsal Sanches Zied Rasslan Marilda Lauretti S. Guedes

In order to find out whether there exists a relationship between HDL and LDL serum levels and atherosclerotic plaques in the carotid artery (CA), a prospective study was carried out involving 125 patients. They were aleatorily included, of both sexes and age between 45-75 years old. HDL and LDL serum levels were measured as well CA ultrasonographic mode B investigated. It was verified that the number of patients having atherosclerotic plaques in CA was inversely proportional to the HDL levels. We came up with the same ratio when the HDL levels were compared to the number of patients having CA stenosis. These results were statistically signifcant (x2=6.57 and x2=9.24 respectively; critical x2=5.99 to α =5%). A direct ratio was also found out in the relationship between the presence of atherosclerotic plaques in the CA and the LDL serum levels (greater in patients with plaques). However no relationship between LDL levels and the occurrence or not of CA stenosis in patients having plaques was demonstrated. The results were not statistically significant (x2=0.97 and x2=0.41, respectively, critical x2=5.99 to α =5%). The obtained results seem to be at least in part in agreement with literature findings. Statistically significative results in the comparison of HDL and LDL levels with the grade of stenosis of the CA were not found out (x2=11.78 and x2=4.03, respectively; critical x2=12.59 to α =5%).

atherosclerosis; stenosis; cholesterol; carotid artery

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