Protective Role of Ferulic Acid on Testis-Histoarchitecture and Oxidative Damages Induced by Dimethoate in Rats

HIGHLIGHTS

• Dimethoate caused reproductive toxicity.

• Ferulic acid ameliorated some parameters.

• Histopathology and oxidative stress are very important criters.

Abstract

Dimethoate is frequently used all over the world and it caused serious toxicity on target and non-target organisms. In this study, distilled water, ferulic acid, low dose dimetoate, high dose dimetoate, ferulic acid and low dose dimetoate, ferulic acid and high dose dimethoate were given to rats through gavage during the 4-week experiment. For this purpose, the levels of glutathione peroxidase, superoxide dismutase, glutathione-S-transferase, catalase, malondialdehyde and histopathological damages were investigated. After 28 days, no statistically important difference was determined in all investigated parameters in testicular tissues of rats who were administered control and ferulic acid. When the control and ferulic acid groups compare with the low and high dose dimetoate groups, there were statistically significantly changes antioxidant enzymes and malondialdehyde levels. In ferulic acid plus low dose dimethoate treated group and ferulic acid plus high dose dimethoate treatment we demonstrated that the protective role of ferulic acid on examining parameters but not completely. Based on light microscope studies, we can say that both dose dimethoate induced numerous histopathological changes. Less pathological alterations were observed when rats ferulic acid-plus-dimethoate. As a result, it is possible to say that ferulic acid has a partially healing role on the oxidative damage caused by dimethoate.

Keywords:
Pesticide toxicity; ferulic acid; oxidative stress; histopathology; testicular dysfunction