csc
Ciência & Saúde Coletiva
Ciênc. saúde coletiva
1413-8123
1678-4561
ABRASCO - Associação Brasileira de Saúde Coletiva
Rio de Janeiro, RJ, Brazil
Atualmente, com o advento da terapia antirretroviral potente e o aumento da sobrevida dos pacientes pediátricos infectados pelo HIV, a busca da promoção de uma melhor qualidade de vida deve ser o foco principal na atenção a crianças vivendo com HIV/Aids. Torna-se necessária a utilização de um instrumento adequado a este grupo visando à investigação e à avaliação da sua qualidade de vida. Este estudo objetivou realizar validação da Escala de Qualidade de Vida da Criança em crianças infectadas pelo HIV atendidas em Serviços de Sida/Aids do Rio de Janeiro (RJ). Esta escala é composta de 26 perguntas e sua aplicação ocorreu em 100 crianças entre quatro e 12 anos e seus responsáveis. A análise estatística realizada utilizou correlações canônicas, intervalo de confiança e teste c². O ponto de corte obtido foi 49; a consistência interna expressa por um alfa de Cronbach da ordem de 0,73 para as crianças e 0,67 para os responsáveis. O perfil de resposta demonstrou satisfação elevada para itens como férias e aniversário, e os de menor satisfação foram internação e brincar sozinho. Conclui-se que a escala apresentou medidas psicométricas satisfatórias, tornando-se um instrumento confiável, consistente, válido e recomendável de mensuração da qualidade de vida de crianças infectadas pelo HIV.
TEMAS LIVRES FREE THEMES
Validation study of a scale of life quality evaluation in a group of pediatric patients infected by HIV
Estudo de validação de uma escala de qualidade de vida em um grupo de pacientes pediátricos infectados pelo HIV
Dennis de Carvalho FerreiraI; Mauro Romero Leal PassosI; Norma de Paula Motta RubiniII; Rosiangela Ramalho de Souza KnuppIII; José Alexandre da Rocha CurveloIV; Helena Lucia Barroso dos ReisV; Gesmar Volga Haddad HerdyV
ISetor de Doenças Sexualmente Transmissíveis, Universidade Federal Fluminense. Outeiro de São João Batista s/nº, Campus do Valonguinho, Centro. 24210-150. Niterói RJ. carvalhoferr@yahoo.com.br
IIServiço de Aids Pediátrica, Departamento de Imunologia e Alergia, Universidade Federal do Estado do Rio de Janeiro
IIIDepartamento de Odontologia Social e Preventiva, Faculdade de Odontologia, Universidade Federal do Rio de Janeiro
IVDepartamento de Microbiologia Geral, Universidade Federal do Rio de Janeiro
VDepartament de Pediatria, Universidade Federal Fluminense
ABSTRACT
With the advent of potent antiretroviral therapy and the increase in life expectancy of pediatric patients infected with HIV, the quest for the promotion of enhanced quality of life should currently be the main focus in care of children with HIV/Aids. The scope of this study was to validate the Scale of Children's Quality of Life in a group of children infected with HIV receiving clinical care in Aids Service Units in Rio de Janeiro, Brazil. This scale consists of 26 questions and was tested on 100 children, with ages varying between 4 and 12, and their respective parents or guardians. Statistical analysis was conducted using canonical correlation and confidence interval analysis and the c2 test. The results showed that the cut-off point obtained was 49; the internal consistency with Cronbach's alpha was 0.73 for the children and 0.67 for parents or guardians. The response profile revealed marked satisfaction with aspects such as vacations and birthdays, though less satisfaction with items including hospitalization and playing alone. The conclusion was that the scale revealed satisfactory psychometric measurements, proving to be a reliable, consistent, valid and recommended instrument for measuring the quality of life of children infected with HIV.
Key words Quality of life, Children, HIV infection, Self-questionnaire, Validation
RESUMO
Atualmente, com o advento da terapia antirretroviral potente e o aumento da sobrevida dos pacientes pediátricos infectados pelo HIV, a busca da promoção de uma melhor qualidade de vida deve ser o foco principal na atenção a crianças vivendo com HIV/Aids. Torna-se necessária a utilização de um instrumento adequado a este grupo visando à investigação e à avaliação da sua qualidade de vida. Este estudo objetivou realizar validação da Escala de Qualidade de Vida da Criança em crianças infectadas pelo HIV atendidas em Serviços de Sida/Aids do Rio de Janeiro (RJ). Esta escala é composta de 26 perguntas e sua aplicação ocorreu em 100 crianças entre quatro e 12 anos e seus responsáveis. A análise estatística realizada utilizou correlações canônicas, intervalo de confiança e teste c2. O ponto de corte obtido foi 49; a consistência interna expressa por um alfa de Cronbach da ordem de 0,73 para as crianças e 0,67 para os responsáveis. O perfil de resposta demonstrou satisfação elevada para itens como férias e aniversário, e os de menor satisfação foram internação e brincar sozinho. Conclui-se que a escala apresentou medidas psicométricas satisfatórias, tornando-se um instrumento confiável, consistente, válido e recomendável de mensuração da qualidade de vida de crianças infectadas pelo HIV.
Palavras-chave: Qualidade de vida, Crianças, Infecção pelo HIV, Autoquestionário, Validação
Introduction
The acquired immunodeficiency syndrome (Aids) was first described in 1981 and as the years passed, this disease was disseminated to women and men with heterosexual behavior and to children by vertical transmission, taking the identity of a pandemic of rapid expansion, reaching potentially all the world population1.
With a growing number of cases in women in fertile age what is the responsible factor for the increase of the cases in children, since the main transmition via in these cases is the vertical one (virus transmition by the transplacental via, during delivery or through breast feeding2-5.
In Brazil, this transmition via is responsible for about 83,6% of the total of cases of Aids in children, according to data for the year 20044. However, with the implantation of the chemoprophylaxis of the HIV vertical transmition6, it has occurred a high reduction in this transmition via, hoping it reaches rates smaller than 3% as declare the scientific evidences4,7.
With the arrival of the combined antiretroviral therapy, we could observe an improvement in the clinical manifestations in children and it consequently resulted in an increase of their survival and in an improvement of their life quality8.
On the other hand, the new therapy also imposed some challenges such as the regular time table of the medicines, what will involve the responses in the control and motivation of their use8,9; problems with bad therapy adhesion10; the medicines' palatability9; the adverse effects such as intolerance and toxicity8,9; the regular visits to the doctor and the regular exams9,11-13; the necessity of a hyper caloric diet14,15; an increase in the frequency of diseases such as caries (leading to a bigger inconvenient in food ingestion, leading also to problems of dental fitting, with possible phonation disturbances)16.
In the same way, the new therapy also imposed the conscience that these medicines still do not represent the definitive cure to the infection8,10,12,13.
Allied to these factors there are those of psychosocial and emotional order, such as the responses loss1; the stigma of Aids orphans and victimization in education17; the rejection, the adoption or their insertion in foster homes; the moment of the diagnosis revelation17; the acceptance of their own infection and the familiarity with the disease17,18; the representations of themselves as infected ones18; the fear of the future18; their position at school19, with their friends18 and relatives18; and the prejudice18.
Several there are the life dimensions of children who the HIV infection reaches, leading to a change in some concepts and ideas, such as the change of the stigma of "terminal disease" to "disease of chronic character", and the proposal of a new model of family and of evaluation of the infected individual8,17,20,21.
This way, we can conclude that this chronic disease affects the individual's life in emotional, physical and social factors. All these factors contribute to the patient's adjustment to his pathology and his perception of the impact in his life quality22,23.
The attendance and accompanying of these children infected by HIV have only transcended the clinical, the laboratorial and the therapeutic aspects, considering a traditional model, having as its main focus these children's life quality1,8,21.
The infection by HIV/Aids brought a new boarding more qualitative in the attendance, with bigger emphasis in pediatric patients through a multi-disciplinary view imposed to the health professionals, with the finality of avoiding, disregarding or reducing the clinical manifestations, promoting their increase and their development inside the normality patterns and also preventing or diminishing the psychosocial consequences that they face8,19,20-23. Because, unfortunately, we haven't reached yet what could be considered a decisive factor in the disease elimination1,9.
To study the quality of life of pediatric patients infected by HIV is of extreme importance, since the child and the teenager have different degrees of perception of themselves and of the world, according to the period of development in which they are, and they can not be standardized in a single conception of personal satisfaction24. Another relevant point is what some studies have already shown, the perceptions of the parents and of the medical team that was in contact with the children under evaluation in general presented low rates of correlation with the childish self-evaluation25,26.
This way, by definition, quality of life with emphasis in health is understood as the individual's perception in relation to his situation inside the reality of his culture and of the values of the society in which he lives. This way, it points his goals, expectations, patterns and interests according to the description of the World Health Organization (WHO)27.
Several scales have already been proposed by the literature to that finality in individuals without systemic alterations28-31 as well as in individuals who have pathologies of chronic character29,32, such as the multiple sclerosis33, the epilepsy23,34-39, the sarcoidosis39,40, the childhood neoplasies22,41, the sleep apnea41 and rheumatic diseases inclusively in the adolescence42,43 and in children infected by HIV/Aids44-48.
In this specific group, there were used in general extensive, complex47 questionnaires of quality of life that preferentially tried to establish significance with the use of antiretroviral medicines, observing their influence in the child's life45-47. These questionnaires were restricted the clinical aspects of the infection45,48, establishing correlations of low intensity with the psychosocial factors45.
Until today, no tool was capable to comprise all the domains of life of children without systemic alterations or of children in some kind of pathological state28,30,31, although all the formulated and validated ones were used to this finality, since the quality of life is a concept which incorporates the different faces of an individual's life and introduces one aspect of conception that is hard to quantify19.
In this context, the present study used the Child Quality of Life Scale (AUQUEI, Autoquestionnaire Qualité de Vie Enfant Imagé), developed by Manificat & Dazord in 1997, translated and validated in Brazil by Assumpção Jr et al. in 200027,49.
This questionnaire was chosen because it is a tool that proposes itself to evaluate the subjective state of present satisfaction, or better, the subjective sensation of well-being of the individual in focus, considering that the individuals under development (children) are capable of expressing themselves regarding their subjectivity. This questionnaire is, at the same time, considered useful and skilful to check the children's feelings regarding their present state, since it does not leave from inferences accomplished according to its performance and its productivity27,49.
Inside the big quantity of scales and questionnaires proposed to evaluate the quality of life by the literature, and, at the same time, because of the need of adequate instruments in our environment, this study's objective was to accomplish the validation of the Child Quality of Life Scale in a group of children infected by HIV that were under clinical attendance in services of Aids from Rio de Janeiro (RJ, Brazil).
Methodology
This is a descriptive, quantitative and observational study in which the quality of life scale application was accomplished in an individualized way by an interview in a group of children infected by HIV who were chosen randomly. During the questionnaire application, the children were not aware of their responses' answers, and the responses were not aware of the children's answers. The data were collected between March and July of the year 2005.
The sample was of 100 children infected by HIV, who were under clinical attendance, in the pediatric HIV/Aids Ambulatories from the Centro Previdenciário de Niterói (CPN) and from the Hospital Gafrée e Guinle (HUGG), RJ, with age ranging from 4 to 12 years old. At the same time, these questionnaires were also applied to their responses (100 individuals), to acquire their perceptions of the children's quality of life, aiming its validation.
The children's responses were subdivided in mother, father, institutional caregiver (shelters and institutions' responses) and domicile caregiver (grandparents, uncles, cousins, adoptive parents).
The Aids services which acted as research field were chosen because they are centers of reference in the treatment of the infection by HIV for more than ten years, and because they were coordinated by qualified professionals.
The patients were attended in their days of monthly medical appointment, as part of the clinical routine, where after a raffle of the set children, the present study was explained to the responses and those who agreed to participate had to fill the identification form and signed the term of free and enlightened permission.
The scale was based on the point of view of the children's satisfaction viewed by four figures which are associated to several life domains, accessed by 26 questions which explored familiar and social relationships, activities, health, corporal functions and separation27,49.
Those domains were:
. Autonomy Factor 1 (questions: 12, 15, 17, 18, 19 and 24) regarding independence, relations with partners and evaluations;
. Leisure Factor 2 (questions: 7, 9, 11, 21, 25 and 26) regarding vacation, birthday, relation with grandparents;
. Functions Factor 3 (questions: 1, 2, 4, 5, 8, 14 and 20) regarding to school activities, meals, going to bed, going to see the doctor;
. Family Factor 4 (questions: 3, 6, 10, 13, 16, 22 and 23) regarding the opinion about the figures of their parents and about themselves.
The scale is a self-evaluation which uses the images and where the child answers the questions and each one present a domain (in number of 4) and the answers (in number of 4) are represented with the help of faces which express different emotional states, like: very unhappy, unhappy, happy and very happy.
It is then asked to the child to point, without definite time, the answer that better corresponds to her feeling in front of the proposed domain (in this case, the presented question). However, it is initially asked to the child to present an experience lived during each alternative. This permits the child to comprehend the situations and to present her own experience. This way, the scale permits to obtain a satisfaction profile of the child in front of different situations. The used questionnaire was established as followed:
The answers obtained in the application of the scale of quality of life were punctuated from 0 to 3 according to faces' mood represented. The scale is a self-evaluation which uses the images and where the child answers the questions and each one present a domain (in number of 4) and the answers (in number of 4) are represented with the help of faces which express different emotional states, like: very unhappy, unhappy, happy and very happy.
It is then asked to the child to point, without definite time, the answer that better corresponds to her feeling in front of the proposed domain (in this case, the presented question). However, it is initially asked to the child to present an experience lived during each alternative. This permits the child to comprehend the situations and to present her own experience. This way, the scale permits to obtain a satisfaction profile of the child in front of different situations. The sum of this punctuation constitutes the score of each questionnaire.
The validation of an instrument of quality of life requires the evaluation of the obtained data by the application of this scale or questionnaire in individuals definite in time and place, to observation of the internal consistence and reliability of this instrument and its effectiveness29,33.
About the external validation, this scale was applied in a specific group of children infected by HIV, considering that the results obtained in the present study may be inferred to the target population.
Even though, the application of the same scale in the responses was done to verify the concordance of their answers with those from the children to contribute to the instrument reliability.
The test was not done a second time, since the concept of quality of life is mutable, depending on the situations of the moment of its application and a lot of patients were attended only once a month.
The results were statistically treated by the program SPSS version 10.0. With the finality of evaluating the existence of an association between two collections of variants in the groups of children and responses, it was done the analysis of canonical correlation. The comparison of each group's factors (children and responses) was done by the non parametric c2 test.
To obtain the internal validation or reliability of the present study it was used the Cronbach's alpha coefficient.
This study was approved by the Ethics' Committee in Human Research from the Federal University of Fluminense (RJ).
Results
The questionnaire was applied in 106 patients and six children were excluded because they showed difficulty to comprehend the formulated questions.
The distribution of the children infected by HIV evaluated in this study, were separated according to gender and age, and showed that between the age of 4 to 6, there was 23% among 10 girls and 13 boys. For the age between 6 to 8 the frequency was about 24% with 16 girls and 8 boys. For the group represented by the age between 8 to 10 showed 23% with 12 girls and 11 boys. Finally the last group was represented by the age between 10 to 12 with 30 % among 19 girls and 11 boys. The female gender exhibited the highest frequency (57%) followed by the age group in the class of 10 to 12 years old.
The distribution of the responses for the children infected by HIV who participated of this present study, was 14 institutional caregivers (14%), 36 domicile caregivers (36%), 44 mothers (44%) and 6 fathers (6%). This way we observe that half the children were under custody of the caregivers.
The mean of points obtained in each question was similar between children and responses as Graphics 1 and 2 show. The obtained answer profile demonstrates high satisfaction to the items concerning vacations (question 21), birthday (question 11), recreation (questions 1, 3 and 7), grandparents (question 25), photography (question 6) and television (question 26). In the same way, the items with smaller satisfaction are: internment (question 14), playing alone (question 15) and being distant of the family (question 23).
The general score obtained was of 50,7 points, with standard deviation of 7,8 to the children and 50,1 points with standard deviation of 6,4 to the responses, without significant difference between the two groups (p=0,6922). There either was statistically significant difference (p=0,2519) between the feminine (50 ± 7,5) and the masculine (51,8 ± 7,5) populations and we can say that the samples of both genders presented equivalent scores. This way, to the confidence interval of 95%, it was obtained a cut off point of 49 (28-72) to the general population, under which, we may consider the quality of life of the studied population impaired.
The evaluated version showed to be satisfactory considering the internal effectiveness, with a Cronbach's alpha coefficient of 0,73 for the children and of 0,67 for the responses. These results indicate that the characteristics are satisfactory regarding the reliability.
Considering the four factors which compose the scale (autonomy, leisure, functions and family), it was obtained positive correlation between all of them for the children and for the responses, characterizing the effectiveness of the scale construction (Tables 1 and 2).
The result indicates the factors 1 and 3, 1 and 4, 2 and 3 and 2 and 4 as significant (p<0,05) for the children, so it is clearly rejected the hypothesis of inexistence of association and, on the other hand, there is no relation between 1 and 2 , 2 and 4 and 3 and 4.
Discussion
The scale of life quality of the child was described as a multi-dimensional and generic instrument which permitted the mensuration of the life quality of a group of children infected by HIV, initially leaving from its validation in the study's population, and being characterized as objective27,49.
The present scale showed satisfactory psychometric properties, and it also counts on the help of images that come to the encounter of the playful universe of the child, stimulating her interest during the evaluation, since it presents easy application as described by its authors27,49, what was confirmed in this study, including the four domains of life considered of great influence in the infantile development.
Another characteristic showed by the questionnaire was its facility to be reproduced, what identifies it inside the concepts of a scale considered ideal33, following the same model used when it was validated in Brazil28, as it was applicable in a group of children infected by HIV, classified as chronic patients, without going through alterations, signaling its flexibility, similar to when it was applied in children without systemic alterations27.
About its constitution, the questionnaire possesses a structural extension considered favorable (26 questions) regarding other instruments that measure life quality, which vary from 10 to 151 items. This scale showed itself opportune to be used in pediatric patients, since this group is exposed to a higher degree of dispersion than grown ups. And, because it is not extensive, it was not tiring, so that it did not incur in information obliquity (induction of the children in their answers)50.
The found results are useful in the evaluation of the influence of the care given to these patients and in measuring the disease's repercussion, and not in the incapacity generated by this33,45. Once these children are inserted in a program of multi-disciplinary attendance in Aids (with the participation of doctors, nurses, psychologists, volunteers and others), what stimulates the necessity of the accomplishment of a stratified analysis of these punctuations to suggest to the services what factors need intervention29,33,39,45.
This way, studies45,46,47 evaluating life quality and doing correlations between the impact of some antiretroviral medicines and the adhesion to treatment are frequently described. Remaining focused in the biomedical tradition, emphasizing only clinical and therapeutical aspects, reducing other aspects of the patients' life as the social, cultural, psychological and emotional life experiences which directly influence the adhesion to the proposed treatment and to the fact of living with HIV19.
It becomes interesting to emphasize that the present researchers are not in ideal position to do a homogeneous and universal classification of quality of life to pediatric patients with pathologies of chronic character28,29,32,42.
The lack of suitable evaluation means to this specific group; the singularities of each disease29,32,42, as the several levels of infection evolution and patients' adaptation51 are criterions that make difficult the quality of life evaluation.
In a general way, for children chronically sick, an extremely important point is the value of the negative experiences inside their life history, what allows us to check their tolerance to frustration (essential capacity of the human being), outlining their adaptation in front of conflicts and losses which compose their development in the evolutionary process52,53.
Added to this fact, children, in most of the times, present a vision of themselves and of the world that is very different from that of teenagers and grown ups (including their parents and the medical team)25,26. As it was observed in a study which evaluated individuals with age under 15 years old and who possessed cancer diagnosis, inside the group of 124 components, 13 considered the disease a positive event in their lives53. This justifies the importance of the application and validation of the present scale in children infected by HIV.
It is reasonable to say that, in 20 years, the infection by HIV incorporated concepts, prejudices and paradigms which characterize it, but that still are under transformation, as we can observe with the increase of the survival of the infected children, who are already able to cross the adolescence and reach the youth8,10,13,21.
Inside this reality, it is roused the interest in a healthy and safe sexual education in this age group, since scientific evidences show precocity in the first sexual relation in the age group between 11 and 13 years old, for men and women54. It is also observed greater vulnerability originating from faults or inconsistencies in preservatives' use, united to the high rate of sexual activity with different partners, constituting an increasing risky behavior for acquisition of sexually transmitted diseases (STD) and for dissemination of the infection by HIV, once his group is already infected by this virus54.
These observations become very revealing, because about 30% of our sample was between 10 and 12 years old. It is then pointed out the necessity of some specific educational programs to this group54.
About the responses' participation, we emphasize that half of them were caregivers, what shows that the separation of one parent or of both of them, reflecting the loss of them because of death or because of their incapacity to take care of their children, or even because of rejection. Some of these children are in infantile institutions; others are under guardianship of close relatives, or under care of adoptive parents, making clear the social risk to which they are exposed, even though it is sought mechanisms of psychosocial compensation.
These results are equivalent to those observed by another group of researchers45, who checked that less than 30% of the children infected by HIV lived with their parents and 50% lived with responses constituted by relatives.
The similar answer pattern for the questions punctuation of the children and of their responses suggests the great nearness in terms of familiarity between these two groups, promoted by the pathological state of the infection by HIV, reinforcing their emotional and affective links. These data correspond to a requirement described as essential in an evaluation instrument of quality of life, which is to avail oneself of information from responses of the treatment with the child55.
This concordance of answers contributed to the reliability of this instrument, since it did not occur significant difference between the two groups (p=0,6922). However, these findings differ from those which were already proposed in other studies, where it was considered that the concordance of responses' answers would be changed in cases of children with chronic diseases, because, in a distinct way, the grown up's evaluation is based in inferences about the real state of satisfaction of the child, anchored in their own level of cognition and affective development of grown up, different from the analysis of the reality accomplished by the child28.
The high satisfaction for the items concerned to vacation, birthday, amusement, grandparents, photography and television obtained in the answer profile show greater representation for the domains of leisure and family. These results agree with those observed by other authors regarding leisure, with a small variation for the domain of functions. This illustrates the leisure impact in childhood and, at the same time, the fact that the experience of a chronic disease is dynamic and complex, also reaching the patient's family34,36,39.
The items relative to smaller satisfaction like internment, playing alone and being distant from family, repeating, in a similar way, the results of other authors that also used this scale28,49.
About the cut off point, it was 49 for the confidence interval of 95% (varying from 28 to 72 points), under which we may consider the life quality of the studied population impaired. This measure was also used in other studies, because the quality of life is an extremely subjective field and variable in its concepts, according to cultures, regions, pathological and psychosocial conditions, what differs it from the classic definitions of diseases and systemic alterations33,35.
To measure the internal consistence (internal effectiveness), the Cronbach's alpha coefficient was used. This test was applied to the children and to their responses and both of them were satisfactory, with values of 0.73 and 0.67, respectively, similar to those observed by other authors in the validation of other scales of quality of life evaluation33,35.
About the effectiveness of the construction of a scale, a collection of 26 variants tried to measure the satisfaction of children infected by HIV. These were divided in four domains regarding several dimensions of an individual's life, which were named factors. The existence of an association was evaluated (Tables 1 and 2), where occurred positive correlation between the four factors that compose the scale (autonomy, leisure, functions and family) for the children and for their responses. Some of these factors showed greater correlation intensity than others regarding the satisfaction profile of the child and of the grown up, since both of them possess different visions of life and of the world.
Regarding the importance of evaluating the quality of life of children infected by HIV, we may conclude that the used scale showed satisfactory psychometric measures, and it can be recommended as a consistent, reliable and valid instrument in this sample. Besides, it presents an easy application in this specific group of pediatric patients, when accomplished as an interview.
It can also be useful as a model for characterization of other groups of pediatric patients with other pathologies of chronic character, needing to be validated also in these groups56. In the same way, it was skillful to obtain the nature of the "health" and satisfaction states of the individuals from the present study regarding their life quality.
Collaborations
DC Ferreira assisted in all the stages of the article, especially in data gathering; MRL Passos and NPM Rubini helped to structure the study; RRS Knupp and GVH Gerdy conducted the statistical analysis and HLB Reis and JAR Curvelo organized the tabulation and results.
Artigo apresentado em 30/09/2008
Aprovado em 24/06/2009
Versão final apresentada em 04/09/2009
1
1. UNAIDS. Report on the global HIV/AIDS epidemic: 4th global report. Geneva: UNAIDS; 2004.
Report on the global HIV/AIDS epidemic: 4th global report
2004
2. Kourtis AP. Prevention of perinatal HIV transmission: current status and future developments in antiretroviral therapy. Drugs 2002; 62(2)213-220.
Prevention of perinatal HIV transmission: current status and future developments in antiretroviral therapy
Drugs
2002
213
220
2
62
Kourtis
AP
3
3. Brasil. Ministério da Saúde. Definição nacional de caso de Aids em indivíduos menores de 13 anos, para fins de vigilância epidemiológica. Brasília: Ministério da Saúde; 2001.
Definição nacional de caso de Aids em indivíduos menores de 13 anos, para fins de vigilância epidemiológica
2001
4
4. Brasil. Ministério da Saúde. Programa Nacional de DST e Aids: recomendações para a profilaxia da transmissão vertical do HIV e terapia anti-retroviral em gestantes. Brasília: Ministério da Saúde; 2004.
Programa Nacional de DST e Aids: recomendações para a profilaxia da transmissão vertical do HIV e terapia anti-retroviral em gestantes
2004
5. Succi RCM. HIV/Aids: reduzir a transmissăo materno-infantil é necessário ou é possível? Jornal de Pediatria 1997; 73(2):65-66.
HIV/Aids: reduzir a transmissão materno-infantil é necessário ou é possível?
Jornal de Pediatria
1997
65
66
2
73
Succi
RCM
6. Lissauer T, Clayden G. Manual ilustrado de pediatria. Rio de Janeiro: Guanabara Koogan; 1998.
Manual ilustrado de pediatria
1998
Lissauer
T
Clayden
G
7
7. Brasil. Ministério da Saúde. Boletim Epidemiológico Aids e DST: dados epidemiológicos Aids. Brasília: Ministério da Saúde; 2004.
Boletim Epidemiológico Aids e DST: dados epidemiológicos Aids
2004
8. Rubini N. Aids pediátrica. In: Passos MRL, organizador. Deessetologia DST 5. Rio de Janeiro: Cultura Médica; 2005. p. 167-178.
Deessetologia - DST 5
2005
167
178
Rubini
N
Passos
MRL
9. Leggot J. Oral manifestations of HIV infection in children. Oral Surg Oral Med Oral Pathol 1992; 73(2):187-193.
Oral manifestations of HIV infection in children
Oral Surg Oral Med Oral Pathol
1992
187
193
2
73
Leggot
J
10. Rubini N. Efeitos adversos dos ARVs em crianças e adolescentes. Açăo Anti-Aids 2004; 51:8.
Efeitos adversos dos ARVs em crianças e adolescentes
Ação Anti-Aids
2004
8
51
Rubini
N
11
11. Brasil. Ministério da Saúde. Programa Nacional de DST e AIDS: guia de tratamento clínico da infecção pelo HIV em crianças. Brasília: Ministério da Saúde; 2004.
Programa Nacional de DST e AIDS: guia de tratamento clínico da infecção pelo HIV em crianças
2004
12. Directrices para el uso de antirretrovíricos en adolescents y adultos infectados por VIH1. Temas da actualidad: current topics. Rev Panam Salud Publica 2001; 10(3):202-216.
Directrices para el uso de antirretrovíricos en adolescents y adultos infectados por VIH1: Temas da actualidad: current topics
Rev Panam Salud Publica
2001
202
216
3
10
13. Bartlett JG. The Johns Hopkins Hospital: assistęncia clínica ao paciente com HIV/Aids guia prático. Rio de Janeiro: Revinter; 1999.
The Johns Hopkins Hospital: assistência clínica ao paciente com HIV/Aids - guia prático
1999
Bartlett
JG
14. Gonçalves ES. Nutriçăo Superpositiva 2: para gestantes e crianças vivendo com HIV/Aids. Rio de Janeiro: Abia; 1999.
Nutrição Superpositiva 2: para gestantes e crianças vivendo com HIV/Aids
1999
Gonçalves
ES
15. Thomaz PH. Manual de boa alimentaçăo para pacientes portadores de HIV e Aids. Săo Paulo: BMS Virologia; 2000.
Manual de boa alimentação para pacientes portadores de HIV e Aids
2000
Thomaz
PH
16. Ferreira DC, Dias APV, Godefroy P, Gardioli D. Aspectos orais da infecçăo pelo HIV em pacientes pediátricos: uma abordagem atual. DST J Bras Doenças Sex Transm 2004; 16(2):53-57.
Aspectos orais da infecção pelo HIV em pacientes pediátricos: uma abordagem atual
DST - J Bras Doenças Sex Transm
2004
53
57
2
16
Ferreira
DC
Dias
APV
Godefroy
P
Gardioli
D
17. Carvalho CML, Braga VAB, Galvăo MTG. Aids e saúde mental: revisăo bibliográfica. DST J Bras Doenças Sex Transm 2004;16(4):50-55.
Aids e saúde mental: revisão bibliográfica
DST - J Bras Doenças Sex Transm
2004
50
55
4
16
Carvalho
CML
Braga
VAB
Galvão
MTG
18. Saldanha AAW, Figueiredo MAC, Coutinho MPL. Atendimento psicossocial ŕ Aids: a busca pelas questőes subjetivas. DST J Bras Doenças Sex Transm 2004;16(3):84-91.
Atendimento psicossocial à Aids: a busca pelas questões subjetivas
DST - J Bras Doenças Sex Transm
2004
84
91
3
16
Saldanha
AAW
Figueiredo
MAC
Coutinho
MPL
19. Schwarzstein J, Pinto TCR, Branco CAC. A Aids e a escola: nem indiferença, nem discriminaçăo. Rio de Janeiro: Abia; 1993.
A Aids e a escola: nem indiferença, nem discriminação
1993
Schwarzstein
J
Pinto
TCR
Branco
CAC
20. Terto Júnior V, Pimenta C, Parker R, Guimaraes M, Lima DB, Raxach JC. Qualidade de vida para pessoas vivendo com HIV/Aids: aspectos políticos, socioculturais e clínicos. Rio de Janeiro: Abia; 2004.
Qualidade de vida para pessoas vivendo com HIV/Aids: aspectos políticos, socioculturais e clínicos
2004
Terto Júnior
V
Pimenta
C
Parker
R
Guimaraes
M
Lima
DB
Raxach
JC
21. Reaman GH, Haase GM. Quality of life research in childhood cancer. Cancer 1996; 78(6):1330-1332.
Quality of life research in childhood cancer
Cancer
1996
1330
1332
6
78
Reaman
GH
Haase
GM
22. Salgado PCB, Souza EAP. Impacto da epilepsia no trabalho: avaliaçăo da qualidade de vida. Arq Neuropsiquiatr 2002; 60(2-B):442-445.
Impacto da epilepsia no trabalho: avaliação da qualidade de vida
Arq Neuropsiquiatr
2002
442
445
2
60
Salgado
PCB
Souza
EAP
23. Hinds P. Quality of life in children and adolescents with cancer. Semin Oncol Nurs 1990; 6:285-291.
Quality of life in children and adolescents with cancer
Oncol Nurs
1990
285
291
6
Hinds
P
24. Eiser C. Children's quality of life measures. Arch Dis Child 1997; (77):347-350.
Children's quality of life measures
Arch Dis Child
1997
347
350
77
Eiser
C
25. Cannig EH. Mental disorders in chronically ill children: case identification and parent-child discrepancy. Psychosom Med 1994; 56(2):104-108.
Mental disorders in chronically ill children: case identification and parent-child discrepancy
Psychosom Med
1994
104
108
2
56
Cannig
EH
26. Word Health Organization (WHO). Study Protocol for the World Health Organization Project to develop a quality of life assessment instrument (WHQOL). Quality of Life Res 1993; 2:153-159.
Study Protocol for the World Health Organization Project to develop a quality of life assessment instrument (WHQOL)
Quality of Life Res
1993
153
159
2
27. Assumpçăo Jr RFB, Kuczynski E, Sprovieri MH, Aranha EMG. Escala de avaliaçăo de qualidade de vida. Arq Neuropsiquiatr 2000; 58(1):119-127.
Escala de avaliação de qualidade de vida
Arq Neuropsiquiatr
2000
119
127
1
58
Assumpção
Jr RFB
Kuczynski
E
Sprovieri
MH
Aranha
EMG
28. Patrick DL, Deyo RA. Generic and disease-specific measures in assessing health status and quality of life. Medical Care 1989; 27(3):S217-S232.
Generic and disease-specific measures in assessing health status and quality of life
Medical Care
1989
S217
S232
3
27
Patrick
DL
Deyo
RA
29. Hepner KA, Sechrest L. Confirmatory factor analysis of the Child Health Questionnaire-Parent Form 50 in a predominantly minority sample. Quality of Life Research 2002; 11(8):763-773.
Confirmatory factor analysis of the Child Health Questionnaire-Parent Form 50 in a predominantly minority sample
Quality of Life Research
2002
763
773
8
11
Hepner
KA
Sechrest
L
30. Garrat AM, Ruta DA, Abdalla MI, Buckingham JK, Russell IT. The SF 36 health survey questionnaire: an outcome measure suitable for routine use within the NHS? BMJ 1993; 306(29):1440-1444.
The SF 36 health survey questionnaire: an outcome measure suitable for routine use within the NHS?
BMJ
1993
1440
1444
29
306
Garrat
AM
Ruta
DA
Abdalla
MI
Buckingham
JK
Russell
IT
31. Younossi ZM, Guyatt G, Kiwi M, Boparai N, King D. Development of disease specific questionnaire to measure health related quality of life in patients with chronic liver disease. Gut 1999; 45:295-300.
Development of disease specific questionnaire to measure health related quality of life in patients with chronic liver disease
Gut
1999
295
300
45
Younossi
ZM
Guyatt
G
Kiwi
M
Boparai
N
King
D
32. Mendes MF, Balsimelli S, Stangehaus G, Tilbery CP. Validaçăo de escala de determinaçăo funcional da qualidade de vida na esclerose múltipla para a língua portuguesa. Arq Neuropsiquiatr 2004; 62(1): 108-113.
Validação de escala de determinação funcional da qualidade de vida na esclerose múltipla para a língua portuguesa
Arq Neuropsiquiatr
2004
108
113
1
62
Mendes
MF
Balsimelli
S
Stangehaus
G
Tilbery
CP
33. Fernandes PT, Souza EAP. Inventário simplificado de qualidade de vida na epilepsia infantil: primeiros resultados. Arq Neuropsiquiatr 1999; 57(1):40-43.
Inventário simplificado de qualidade de vida na epilepsia infantil: primeiros resultados
Neuropsiquiatr
1999
40
43
1
57
Fernandes
PT
Souza
EAP
34. Souza EAP. Questionário de qualidade de vida na epilepsia: resultados preliminares. Arq Neuropsiquiatr 2001; 59(3-A):541-544.
Questionário de qualidade de vida na epilepsia: resultados preliminares
Arq Neuropsiquiatr
2001
541
544
3
59
Souza
EAP
35. Guimarăes CA, Souza EAP, Montenegro MA, Cendes F, Guerreiro MM. Cirurgia para epilepsia na infância: avaliaçăo neuropsicológica e de qualidade de vida. Arq Neuropsiquiatr 2003; 61(3-B):786-792.
Cirurgia para epilepsia na infância: avaliação neuropsicológica e de qualidade de vida
Arq Neuropsiquiatr
2003
786
792
3
61
Guimarães
CA
Souza
EAP
Montenegro
MA
Cendes
F
Guerreiro
MM
36. Frayman L, Cukiert A, Forster C, Ferreira VB, Buratini JA. Qualidade de vida de pacientes submetidos ŕ cirurgia de epilepsia. Arq Neuropsiquiatr 1999; 57(1):30-33.
Qualidade de vida de pacientes submetidos à cirurgia de epilepsia
Arq Neuropsiquiatr
1999
30
33
1
57
Frayman
L
Cukiert
A
Forster
C
Ferreira
VB
Buratini
JA
37. Salgado PCB , Souza EAP. Qualidade de vida em epilepsia e percepçăo de controle de crises. Arq Neuropsiquiatr 2001; 59(3-A):537-540.
Qualidade de vida em epilepsia e percepção de controle de crises
Arq Neuropsiquiatr
2001
537
540
3
59
Salgado
PCB
Souza
EAP
39. Souza EAP. Qualidade de vida na epilepsia infantil. Arq Neuropsiquiatr 1999; 57(1):34-39.
Qualidade de vida na epilepsia infantil
Arq Neuropsiquiatr
1999
34
39
1
57
Souza
EAP
40. Cox CE, Donohue JF, Brown CD, Kataria YP, Judson MA. The Sarcoidosis Health Questionnaire. Am J Respir Crit Care Med 2003; 168:323-329.
The Sarcoidosis Health Questionnaire
Am J Respir Crit Care Med
2003
323
329
168
Cox
CE
Donohue
JF
Brown
CD
Kataria
YP
Judson
MA
41. Bigal ME, Fernandes LC, Moraes FA, Bordini CA, Speciali JG. Prevalęncia e impacto da migrânea em funcionários do Hospital das Clínicas da Faculdade de Medicina de Ribeirăo Preto USP. Arq Neuropsiquiatr 2000; 58(2-B):431-436.
Prevalência e impacto da migrânea em funcionários do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP
Arq Neuropsiquiatr
2000
431
436
2
58
Bigal
ME
Fernandes
LC
Moraes
FA
Bordini
CA
Speciali
JG
42. Bradlyn AS, RitcheyAK, Harris CV. Quality of life research in pediatric oncology. Cancer 1996; 78(6):1333-1339.
Quality of life research in pediatric oncology
Cancer
1996
1333
1339
6
78
Bradlyn
AS
RitcheyAK
Harris CV
43. Machado MA, Prado LB, Carvalho LB. Francisco S, Silva AB, Atallah NA, Prado GF. Quality of life of patients with obstructive sleep apnea syndrome treated with an intraoral mandibular repositioner. Arq Neuropsiquiatr 2004; 62(2-A):222-225.
Quality of life of patients with obstructive sleep apnea syndrome treated with an intraoral mandibular repositioner
Arq Neuropsiquiatr
2004
222
225
2
62
Machado
MA
Prado
LB
Carvalho
LB
Francisco
S
Silva
AB
Atallah
NA
Prado
GF
44. Ruperto N, Ravelli A, Pistorio A. Malattia C, Cavuto S, Gado-West L, Tortorelli A, Landgraf JM, Singh G, Martini A. Cross-cultural adaptation and psychometric evaluation of the Childhood Health Assesment Questionnaire (CHAQ) and the Child Heath Questionaire (CHQ) in 32 countries: review of the general methodology. Clin Exp Rheumatol 2001; 19(Supl.23):S1-S9.
Cross-cultural adaptation and psychometric evaluation of the Childhood Health Assesment Questionnaire (CHAQ) and the Child Heath Questionaire (CHQ) in 32 countries: review of the general methodology
Clin Exp Rheumatol
2001
S1
S9
23
19
Ruperto
N
Ravelli
A
Pistorio
A
Malattia
C
Cavuto
S
Gado-West
L
Tortorelli
A
Landgraf
JM
Singh
G
Martini
A
45. Varni JW, Seid M, Smith KT, Burwinkle T, Brown J, Szer IS. The PedsQL in pediatric rheumatology: reliability, validity, and responsiveness of the Pediatric Quality of Life Inventory Generic Core Scales and Rheumatology Module. Arthritis & Rheumatism 2002; 46(3):714-725.
The PedsQL in pediatric rheumatology: reliability, validity, and responsiveness of the Pediatric Quality of Life Inventory Generic Core Scales and Rheumatology Module
Arthritis & Rheumatism
2002
714
725
3
46
Varni
JW
Seid
M
Smith
KT
Burwinkle
T
Brown
J
Szer
IS
46. Préau M, Leport C, Salmon-Ceron D. Health-related quality of life and patient-provider relationships in HIV-infected patients during the first three years after starting PI-containing antiretroviral treatment. Aids Care 2004; 16(5):649-661.
Health-related quality of life and patient-provider relationships in HIV-infected patients during the first three years after starting PI-containing antiretroviral treatment
Aids Care
2004
649
661
5
16
Préau
M
Leport
C
Salmon-Ceron
D
47. Nicolas J, Dazord A, Manificat S. Evaluation of life quality for children infected by HIV: validation of a method and preliminary results. Pediatr Aids HIV Infect 1996; 7(4):254-260.
Evaluation of life quality for children infected by HIV: validation of a method and preliminary results
Pediatr Aids HIV Infect
1996
254
260
4
7
Nicolas
J
Dazord
A
Manificat
S
48. Eriksson LE, Bratt GA, Sandstrom E, Nordström G. The two-year impact of first generation protease inhibitor based antiretroviral therapy (PI-ART) on health-related quality of life. Health and Quality of Life Outcomes 2005; 3(32):1-8.
The two-year impact of first generation protease inhibitor based antiretroviral therapy (PI-ART) on health-related quality of life
Health and Quality of Life Outcomes
2005
1
8
32
3
Eriksson
LE
Bratt
GA
Sandstrom
E
Nordström
G
49. Storm DS, Boland MG, Gortmaker SL, He Y, Skurnick J, Howland L, Oleske JM. Pediatric Aids Clinical Trials Group Protocol 219 Study Team: protease inhibitor combination therapy, severity of illness, and quality of life among children with perinatally acquired HIV-1 infection. Pediatrics 2005; 115(2):173-182.
Pediatric Aids Clinical Trials Group Protocol 219 Study Team: protease inhibitor combination therapy, severity of illness, and quality of life among children with perinatally acquired HIV-1 infection
Pediatrics
2005
173
182
2
115
Storm
DS
Boland
MG
Gortmaker
SL
He
Y
Skurnick
J
Howland
L
Oleske
JM
50. Pearson DA, McGrath NM, Nozyce M, Nichols SL, Raskino C, Brouwers P, Lifschitz MC, Baker CJ, Englund JA. Predicting HIV disease progression in children using measures of neuropsychological and neurological functioning. Pediatrics 2000; 106(6):1-10.
Predicting HIV disease progression in children using measures of neuropsychological and neurological functioning
Pediatrics
2000
1
10
6
106
Pearson
DA
McGrath
NM
Nozyce
M
Nichols
SL
Raskino
C
Brouwers
P
Lifschitz
MC
Baker
CJ
Englund
JA
51. Manificat S, Dazord A. Évaluation de la qualité de vie de l'enfant: validation d'un questionnaire, premiers résultats. Neuropsychiatr Enfance Adolesc 1997; 45(3):106-114.
Évaluation de la qualité de vie de l'enfant: validation d'un questionnaire, premiers résultats
Neuropsychiatr Enfance Adolesc
1997
106
114
3
45
Manificat
S
Dazord
A
52. Medronho RA, Carvalho DMC, Bloch KV, Luiz RR, Werneck G. Epidemiologia. Săo Paulo: Atheneu; 2003.
Epidemiologia
2003
Medronho
RA
Carvalho
DMC
Bloch
KV
Luiz
RR
Werneck
G
53. Postlethwaite RJ, Garralda ME, Eminson DM. Reynolds J. Lessons from psychosocial studies of chronic renal failure. Arch Dis Child 1996; 75(5):455-459.
Lessons from psychosocial studies of chronic renal failure
Arch Dis Child
1996
455
459
5
75
Postlethwaite
RJ
Garralda
ME
Eminson
DM
Reynolds
J
54. Jenney ME, Campbell S. Measuring quality of life. Arch Dis Child 1997; 77:347-350.
Measuring quality of life
Arch Dis Child
1997
347
350
77
Jenney
ME
Campbell
S
55. Holmes HA, Holmes FF. After ten years, what are the handicaps and life styles of children treated for cancer? Clin Pediatr 1975; 14:819-823.
After ten years, what are the handicaps and life styles of children treated for cancer?
Clin Pediatr
1975
819
823
14
Holmes
HA
Holmes
FF
56. Dias APS, Santos DDG, Ferreira DC, Passos MRL, Arze WNC. Estudo comparativo: perfil dos adolescentes atendidos numa clínica de DST nos anos de 1995 e 2003. Adolescęncia & Saúde 2005; 2(2):15-24.
Estudo comparativo: perfil dos adolescentes atendidos numa clínica de DST nos anos de 1995 e 2003
Adolescência & Saúde
2005
15
24
2
2
Dias
APS
Santos
DDG
Ferreira
DC
Passos
MRL
Arze
WNC
57. Mulhern RK, Horowitz ME, Ochs J, Friedman AG, Armstrong FD, Copeland D, Kun LE. Assessment of quality of life among pediatric patients with cancer: psychological assessment. J Consult Clin Psychol 1989; 1(2):130-138.
Assessment of quality of life among pediatric patients with cancer: psychological assessment
J Consult Clin Psychol
1989
130
138
2
1
Mulhern
RK
Horowitz
ME
Ochs
J
Friedman
AG
Armstrong
FD
Copeland
D
Kun
LE
Autoria
Dennis de Carvalho Ferreira
Universidade Federal Fluminense, Setor de Doenças Sexualmente Transmissíveis , Niterói, Rio de Janeiro, BrazilUniversidade Federal FluminenseBrazilNiterói, Rio de Janeiro, BrazilUniversidade Federal Fluminense, Setor de Doenças Sexualmente Transmissíveis , Niterói, Rio de Janeiro, Brazil
Mauro Romero Leal Passos
Universidade Federal Fluminense, Setor de Doenças Sexualmente Transmissíveis , Niterói, Rio de Janeiro, BrazilUniversidade Federal FluminenseBrazilNiterói, Rio de Janeiro, BrazilUniversidade Federal Fluminense, Setor de Doenças Sexualmente Transmissíveis , Niterói, Rio de Janeiro, Brazil
Norma de Paula Motta Rubini
Universidade Federal do Estado do Rio de Janeiro, Departamento de Imunologia e Alergia , Rio de Janeiro, BrazilUniversidade Federal do Estado do Rio de JaneiroBrazilRio de Janeiro, BrazilUniversidade Federal do Estado do Rio de Janeiro, Departamento de Imunologia e Alergia , Rio de Janeiro, Brazil
Rosiangela Ramalho de Souza Knupp
Universidade Federal do Rio de Janeiro, Faculdade de Odontologia , Departamento de Odontologia Social e Preventiva, Rio de Janeiro, BrazilUniversidade Federal do Rio de JaneiroBrazilRio de Janeiro, BrazilUniversidade Federal do Rio de Janeiro, Faculdade de Odontologia , Departamento de Odontologia Social e Preventiva, Rio de Janeiro, Brazil
José Alexandre da Rocha Curvelo
Universidade Federal do Rio de Janeiro, Departamento de Microbiologia Geral , Rio de Janeiro, BrazilUniversidade Federal do Rio de JaneiroBrazilRio de Janeiro, BrazilUniversidade Federal do Rio de Janeiro, Departamento de Microbiologia Geral , Rio de Janeiro, Brazil
Helena Lucia Barroso dos Reis
Universidade Federal Fluminense, Departament de Pediatria , Rio de Janeiro, BrazilUniversidade Federal FluminenseBrazilRio de Janeiro, BrazilUniversidade Federal Fluminense, Departament de Pediatria , Rio de Janeiro, Brazil
Gesmar Volga Haddad Herdy
SCIMAGO INSTITUTIONS RANKINGS
Universidade Federal do Estado do Rio de Janeiro, Departamento de Imunologia e Alergia , Rio de Janeiro, BrazilUniversidade Federal do Estado do Rio de JaneiroBrazilRio de Janeiro, BrazilUniversidade Federal do Estado do Rio de Janeiro, Departamento de Imunologia e Alergia , Rio de Janeiro, Brazil
Universidade Federal Fluminense, Departament de Pediatria , Rio de Janeiro, BrazilUniversidade Federal FluminenseBrazilRio de Janeiro, BrazilUniversidade Federal Fluminense, Departament de Pediatria , Rio de Janeiro, Brazil
Universidade Federal Fluminense, Setor de Doenças Sexualmente Transmissíveis , Niterói, Rio de Janeiro, BrazilUniversidade Federal FluminenseBrazilNiterói, Rio de Janeiro, BrazilUniversidade Federal Fluminense, Setor de Doenças Sexualmente Transmissíveis , Niterói, Rio de Janeiro, Brazil
Universidade Federal do Rio de Janeiro, Departamento de Microbiologia Geral , Rio de Janeiro, BrazilUniversidade Federal do Rio de JaneiroBrazilRio de Janeiro, BrazilUniversidade Federal do Rio de Janeiro, Departamento de Microbiologia Geral , Rio de Janeiro, Brazil
Universidade Federal do Rio de Janeiro, Faculdade de Odontologia , Departamento de Odontologia Social e Preventiva, Rio de Janeiro, BrazilUniversidade Federal do Rio de JaneiroBrazilRio de Janeiro, BrazilUniversidade Federal do Rio de Janeiro, Faculdade de Odontologia , Departamento de Odontologia Social e Preventiva, Rio de Janeiro, Brazil
Ferreira, Dennis de Carvalho et al. Estudo de validação de uma escala de qualidade de vida em um grupo de pacientes pediátricos infectados pelo HIV. Ciência & Saúde Coletiva [online]. 2011, v. 16, n. 5 [Acessado 4 Abril 2025], pp. 2643-2652. Disponível em: <https://doi.org/10.1590/S1413-81232011000500034>. Epub 24 Maio 2011. ISSN 1678-4561. https://doi.org/10.1590/S1413-81232011000500034.
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