Open-access Does prevention for Alzheimer's disease exist?

A prevenção da doença de Alzheimer existe?

Abstract

The prevention of Alzheimer's disease is a growing public health concern amidst an ageing population. Meanwhile, there is no effective or curative treatment available where prevention could greatly reduce health costs. This review was based on reports of potential preventive factors, including modifiable lifestyle factors, as well as preventive pharmacological strategies. Although the present review was not systematic, the reports selected from PubMed using "Alzheimer's disease" and "prevention" as key-words, allow us to affirm that pursuing a healthy lifestyle; physical, cognitive, leisure activities; good social engagement; a high consumption of fish, low consumption of dietary fat and moderate consumption of wine, and control of vascular risk factors appear to be potential factors for delaying dementia.

Key words: Alzheimer's disease; prevention; physical exercise; statins; cholinesterase inhibitors; nutrition.

Resumo

A prevenção da doença de Alzheimer é um problema de saúde pública, enquanto a população está envelhecendo. Por enquanto, não há tratamento efetivo ou curativo e prevenção poderia evitar grandes custos financeiros. Esta revisão foi baseada em estudos sobre potenciais fatores preventivos, incluindo fatores modificáveis de estilo de vida, bem como estratégias farmacológicas preventivas. Embora esta revisão não seja sistemática, estudos selecionados do PubMed, com palavras-chave "Alzheimer's disease" e " prevention", permitem afirmar que ter um estilo de vida saudável, atividades físicas, cognitivas e de lazer; bom engajamento social; aumento no consumo de peixes, redução no consumo de gorduras consumo meoderado de vinho; controle dos fatores de risco vasculares parecem ter vantagens potenciais em retardar a demência.

Palavras-chave: doença de Alzheimer; prevenção; exercício físico; estatinas; inibidores de colinesterases; nutrição.

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Publication Dates

  • Publication in this collection
    Jul-Sep 2009

History

  • Received
    08 July 2009
  • Accepted
    12 Aug 2009
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E-mail: revistadementia@abneuro.org.br | demneuropsy@uol.com.br
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