Abstract in English:

ABSTRACT Objective To review the long-term outcomes (functional status and psychological sequelae) of survivors of critical illnesses due to epidemic viral pneumonia before the COVID-19 pandemic and to establish a benchmark for comparison of the COVID-19 long-term outcomes. Methods This systematic review of clinical studies reported the long-term outcomes in adults admitted to intensive care units who were diagnosed with viral epidemic pneumonia. An electronic search was performed using databases: MEDLINE®, Web of Science™, LILACS/IBECS, and EMBASE. Additionally, complementary searches were conducted on the reference lists of eligible studies. The quality of the studies was assessed using the Newcastle-Ottawa Scale. The results were grouped into tables and textual descriptions. Results The final analysis included 15 studies from a total of 243 studies. This review included 771 patients with Influenza A, Middle East Respiratory Syndrome, and Severe Acute Respiratory Syndrome. It analyzed the quality of life, functionality, lung function, mortality, rate of return to work, rehospitalization, and psychiatric symptoms. The follow-up periods ranged from 1 to 144 months. We found that the quality of life, functional capacity, and pulmonary function were below expected standards. Conclusion This review revealed great heterogeneity between studies attributed to different scales, follow-up time points, and methodologies. However, this systematic review identified negative long-term effects on patient outcomes. Given the possibility of future pandemics, it is essential to identify the long-term effects of viral pneumonia outbreaks. This review was not funded. Prospero database registration: (www.crd.york.ac.uk/prospero) under registration ID CRD42021190296.

Abstract in English:

ABSTRACT Circulatory shock is a common fatal condition. Despite this, information on this syndrome in the current medical literature is fragmented and esoteric. Adherence to each basic element of care can have a profound impact on patient outcomes. Disturbances in pumping (cardiogenic), content/container relationship (hypovolemic and vasoplegic), or blockage in blood circulation (obstructive) can induce tissue hypoperfusion, causing hemodynamic shock. If not quickly reversed, hypoperfusion progresses to irreversible multi-organ failure. The course can be fatal even before reaching this stage in cases of obstructive and anaphylactic shock in which the therapeutic window may last for only a few minutes. Thus, it is essential to conduct a joint analysis of clinical data and routine diagnostic tests to infer the probable cause of shock and avoid delays in the diagnosis of diseases that can deteriorate quickly. Point-of-care ultrasonography and echocardiography are the most valuable non-invasive diagnostic tools. Although lactate-guided management has proven to be effective, the use of capillary refill time, other biochemical markers of perfusion, and preload-directed resuscitation have the potential to avoid volume overload and improve outcomes. Faster intravenous fluid infusion and early use of vasopressors have a strong rational appeal. However, in hemorrhagic shock, finding a balance between avoiding excessive crystalloid administration and maintaining adequate perfusion pressure until hemostasis is achieved remains challenging. This review provides an accessible description of bedside management of shock, including the treatment of the main causes. The most relevant information has been organized into tables for quick reference.

Abstract in English:

ABSTRACT Extracorporeal cardiopulmonary resuscitation is a method of cardiopulmonary resuscitation that uses extracorporeal membrane oxygenation with conventional cardiopulmonary resuscitation and has emerged as a promising intervention for patients with refractory cardiac arrest. This report describes the case of a 44-year-old man at significant risk for mortality according to his high RESCUE-IHCA Score who was awaiting heart transplantation and experienced in-hospital cardiac arrest during hemodialysis. Prompt recognition, immediate activation of the extracorporeal membrane oxygenation team, and initiation of support within 60 minutes contributed to a favorable outcome. This case emphasizes important considerations associated with extracorporeal cardiopulmonary resuscitation implementation, including optimal patient selection, intervention timing, and nuances of cannulation procedures. Continuous monitoring, involvement of a specialized extracorporeal membrane oxygenation team, recognition of extracorporeal membrane oxygenation as bridge therapy, and integration of extracorporeal membrane oxygenation with definitive treatment strategies are highlighted. Extracorporeal cardiopulmonary resuscitation is a vital intervention for patients with refractory cardiac arrest, and adequate patient selection and swift implementation are crucial to improving outcomes. A comprehensive review of extracorporeal cardiopulmonary resuscitation is also presented to highlight its efficacy and challenges associated with in-hospital cardiac arrest.