Analysis of the Influence of Abdominal Obesity on Systemic Arterial Hypertension and on the Lipid Profile on Cardiometabolic Risk Stratification in Adult Women

Cavalcanti, Iury Matheus Lima; Nascimento, Cristian Rodrigues do; Tenório, Pedro Pereira; Araújo, Tiago Ferreira da Silva

doi:10.36660/ijcs.20200415

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International Journal of Cardiovascular Sciences

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Original Article • Int. J. Cardiovasc. Sci. 35 (5) • Sep-Oct 2022 • https://doi.org/10.36660/ijcs.20200415 copy

Analysis of the Influence of Abdominal Obesity on Systemic Arterial Hypertension and on the Lipid Profile on Cardiometabolic Risk Stratification in Adult Women

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Background:

Obesity is a public health problem and has been associated with the development of metabolic disorders that have a strong relationship with the onset of cardiovascular diseases (CVD).

Objective:

The objective was to analyze the influence of abdominal obesity (AO) on systemic arterial hypertension (SAH) and on the lipid profile in cardiovascular risk stratification in adult women.

Methods:

Altogether, 91 women participated in the research. Lifestyle information was collected, in addition to the analysis of clinical measures of cardiovascular risk and biochemical parameters. Unpaired Student's t-test, logistic regression, and Pearson's correlation were performed for data analysis, with a value of p <0.05 considered significant.

Results:

The prevalence of AO was 62.6%. Logistic regression showed that AO increased the chance of developing SAH by 2.9-fold. The same behavior was observed in the TG/HDL-c lipid ratio (3.93 ± 0.3 vs. 2.16 ± 0.2), representing an 82% increase in obese women. The present study also demonstrated that the best anthropometric parameter to analyze cardiovascular risk in the studied population was the waist/height ratio (AUC = 0.707).

Conclusions:

It can therefore be concluded that AO plays a significant role in the development of SAH and changes in lipid values that predict increased cardiovascular risk, configuring a strong influence factor for CVD.

Keywords:
Obesity, Abdominal; Cardiovascular Diseases; Hypertension; Metabolic Syndrome; Risk Stratification; Adult; Women; Lipidic Metabolism; Hyperlipidemias

Parameters	Odds Ratio	CI	P-value
SAH	2.9	1.1 – 4.2	0.0086 ^* * p<0.05.

	PARAMETERS	STANDARD DEVIATION (±)	P-value
SBP
Obese	137.5 mmHg	2.5 mmHg	<0.0001 ^* * p<0,05.
Non-obese	123.6 mmHg	2.5 mmHg	<0.0001 ^* * p<0,05.
DBP
Obese	96.8 mmHg	2.5 mmHg	0.0459 ^* * p<0,05.
Non-obese	85.7 mmHg	85.7 mmHg	0.0459 ^* * p<0,05.
Lipid Ratio TC/HDL-c
Obese	4.02	1.4	0.0005 ^* * p<0,05.
Non-obese	3.10	0.6	0.0005 ^* * p<0,05.
Lipid Ratio LDL/HDL-c
Obese	2.26	1.0	0.0084 ^* * p<0,05.
Non-obese	1.75	0.6	0.0084 ^* * p<0,05.
Lipid Ratio TG/HDL-c
Obese	3.93	0.7	<0.0001 ^* * p<0,05.
Non-obese	2.16	0.5	<0.0001 ^* * p<0,05.
Total Cholesterol
Obese	155.01	12.7	<0.0001 ^* * p<0,05.
Non-obese	143.5	13.8	<0.0001 ^* * p<0,05.
LDL-c
Obese	87.7	12.9	0.0056 ^* * p<0,05.
Non-obese	81.0	6.1	0.0056 ^* * p<0,05.
Triglycerides (TG)
Obese	152.4	21.1	<0.0001 ^* * p<0,05.
Non-obese	100.0	11.1	<0.0001 ^* * p<0,05.
HDL
Obese	38.5	9.0	<0.0001 ^* * p<0,05.
Non-obese	46.3	7.7	<0.0001 ^* * p<0,05.

Parameters	AUC	CI (±)	Sensitivity	Specificity	P-value
Waist circumference	0.695	95%: 0.590 to 0.788	^* * measure not applicable.	^* * measure not applicable.	0.001
Waist-to-height ratio	0.707	95%: 0.602 to 0.798	67.6% (95% CI: 50.2% to 82.0%)	74.1% (95% CI: 60.3% to 85.0%).	0.005
Waist-to-hip ratio	0.664	95%: 0.558 to 0.760	78.4% (95% CI: 61.8% to 90.2%)	55.6% (95% CI: 41.4% to 69.1%);	0.0048
Body Mass Index	0.667	95%: 0.561 to 0.763	45.9% (95% CI: 29.5% to 63.1%)	85.2% (95% CI: 72.9% to 93.4%)	0.0049

Parameters x WHtR	Value of r
SBP (mmHg)	r = 0.465 ^* * p<0.05. (0.287 to 0.614)
DBP (mmHg)	r = 0.276 ^* * p<0.05. (0.132 to 0.377)
TC (mg/dL)	r = 0.330 ^* * p<0.05. (0.133 to 0.502)
TG (mg/dL)	r = 0.443 ^* * p<0.05. (0.261 to 0.595)
LDL-c (mg/dL)	r = 0.195 ^* * p<0.05. (0.120 to 0.385)
HDL-c (mg/dL)	r = -0.133 ^* * p<0.05. (-0.330 to 0.075)

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