Pd/C-mediated dual C-C bond forming reaction in water: synthesis of 2,4-dialkynylquinoline

Pd/C facilitated dual C-C bond forming reaction between 2,4-diiodoquinoline and terminal alkynes in water providing a practical and one-step synthesis of 2,4-dialkynylquinolines. A number of related quinoline derivatives were prepared in good to excellent yields using this water-based methodology. The use of other palladium catalysts and solvents was examined and the mechanism of the reaction has been discussed.

quinoline; palladium; charcoal; copper; C-C bond; alkyne

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