Abstract
A number of glycoconjugates, including glycolipids and glycoproteins, participate in the process of host-cell invasion by Trypanosoma cruzi and one of the most important carbohydrates involved on this interaction is sialic acid. It is known that parasite trans-sialidase participates with sialic acid in a coordinated fashion in the initial stages of invasion. Given the importance of these sialogycoconjugates, this review sets out various possible biological models for the interaction between the parasite and mammalian cells that possess a sialylated receptor/ligand system.
sialoglycoconjugates; Trypanosoma cruzi-host cell; sialic acid; neuraminidase; biologicals models
Sialoglycoconjugates in Trypanosoma cruzi-host cell interaction: possible biological model - a review
Alane Beatriz Vermelho
Maria Nazareth Leal Meirelles1
Instituto Oswaldo Cruz, Departamento de Ultra-estrutura e Biologia Celular, Rio de Janeiro, Brasil
A number of glycoconjugates, including glycolipids and glycoproteins, participate in the process of host-cell invasion by Trypanosoma cruzi and one of the most important carbohydrates involved on this interaction is sialic acid. It is known that parasite trans-sialidase participates with sialic acid in a coordinated fashion in the initial stages of invasion. Given the importance of these sialogycoconjugates, this review sets out various possible biological models for the interaction between the parasite and mammalian cells that possess a sialylated receptor/ligand system.
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Publication Dates
-
Publication in this collection
01 June 2009 -
Date of issue
Mar 1994
