Pulmonary involvement in Schistosomiasis mansoni

Dirceu B. Greco Enio R. P. Pedroso J. R. Lambertucci Manoel O. C. Rocha Paulo Marcos Z. Coelho Pedro Raso Cid S. Ferreira About the authors

Abstract

The post-treatment pulmonary alterations were evaluated in patients (Study 1) and in mice (Study 2) infected with Schistosoma mansoni. Study 1: the patients were examined pre and post-treatment (with ora oxamniquine) and the following exams were performed: sputum for eosinophils and chest x-ray. Study 2: four groups of mice (total = 64) were studied; Group I (infected and treated with oxamniquine); II (infected and not treated); III (not infected and treated) and IV (not infected and not treated). All were x-rayed to check for pulmonary abnormalities pre and post-treatment and lung specimens were studied by optical microscopy and immunofluorescence. We have found abnormalities in the parameters checked in both studies and the results suggest an immunological reaction, probably due to deposition of immune complexes in the lungs, with subsequent activation of the complement system. The experimental study showed that the alterations are not dependent of the presence of eggs and/or worms of S. mansoni in the lungs, thus corroborating the hypothesis of deposition of circulating material.


ABSTRACT

Pulmonary involvement in Schistosomiasis mansoni

Dirceu B. Greco1

Enio R. P. Pedroso1

J. R. Lambertucci1

Manoel O. C. Rocha1

Paulo Marcos Z. Coelho1

Pedro Raso1

Cid S. Ferreira1

Universidade Federal de Minas Gerais, Faculdade de Medicina e Instituto de Ciências Biológicas, Núcleo de Estudos sobre Esquistossomose, Belo Horizonte, Brasil

The post-treatment pulmonary alterations were evaluated in patients (Study 1) and in mice (Study 2) infected with Schistosoma mansoni. Study 1: the patients were examined pre and post-treatment (with ora oxamniquine) and the following exams were performed: sputum for eosinophils and chest x-ray. Study 2: four groups of mice (total = 64) were studied; Group I (infected and treated with oxamniquine); II (infected and not treated); III (not infected and treated) and IV (not infected and not treated). All were x-rayed to check for pulmonary abnormalities pre and post-treatment and lung specimens were studied by optical microscopy and immunofluorescence. We have found abnormalities in the parameters checked in both studies and the results suggest an immunological reaction, probably due to deposition of immune complexes in the lungs, with subsequent activation of the complement system. The experimental study showed that the alterations are not dependent of the presence of eggs and/or worms of S. mansoni in the lungs, thus corroborating the hypothesis of deposition of circulating material.

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Publication Dates

  • Publication in this collection
    26 June 2009
  • Date of issue
    1987
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