Immunological profiles of patients from endemic areas infected with Schistosoma mansoni

Giovanni Gazzinelli Iramaya R. C. Viana Lilian M. G. Bahia-Oliveira Alda Maria S. Silveira Claudia Carvalho Queiroz Omar dos Santos Carvalho Cristiano L. Massara Lucia A. O. Fraga Daniel G. Colley Rodrigo Correa Oliveira About the authors

Abstract

Crude extracts of eggs (SEA) adult worms (SWAP) or cercariae (Cerc) have been used to stimulate Peripheral Blood Mononuclear cells (PBMC) and have provided rather distinct profiles of responses in different types of patients. In genenral it is clear that patients with early infections respond strongly to SEA while response to SWAP are developed more slowly. As infection progresses into the more chronic phases, a general pattern is seen whic leads to lower anti-SEA proliferative responses in the face of higher responses to SWAP and variable anti-cerc responsiveness. Cured not re-exposed patients express very high levels of anti-SEA proliferation. It has recently been seen that those individuals who live in endemic areas and have continued water contact, but are reapeatedly stool-negative (who are presumed to have self-cured or be putatively resistant; endemic normals) are strongly responsive to antigenic extracts, particularly to SEA. Furthermore, our results show that endemic normal individuals have significantly higher IFN gamma production upon PBMC stimulation with schistosome antigens than infected individuals. With the emergence of more studies it is becoming apparent that both the intensity and the prevalence of a given area may influence or shape the general responsiveness of the population under study.

schistosomiasis mansoni; clinical immunology


ABSTRACT

Immunological profiles of patients from endemic areas infected with Schistosoma mansoni

Giovanni Gazzinelli1

Iramaya R. C. Viana1

Lilian M. G. Bahia-Oliveira1

Alda Maria S. Silveira1

Claudia Carvalho Queiroz1

Omar dos Santos Carvalho1

Cristiano L. Massara1

Lucia A. O. Fraga1

Daniel G. Colley2

Rodrigo Correa Oliveira1

FIOCRUZ, Centro de Pesquisas René Rachou, Belo Horizonte, Brasil

Vanderbilt University School of Medicine, Veterans Administration Medical Center, Nashville, USA

Crude extracts of eggs (SEA) adult worms (SWAP) or cercariae (Cerc) have been used to stimulate Peripheral Blood Mononuclear cells (PBMC) and have provided rather distinct profiles of responses in different types of patients. In genenral it is clear that patients with early infections respond strongly to SEA while response to SWAP are developed more slowly. As infection progresses into the more chronic phases, a general pattern is seen whic leads to lower anti-SEA proliferative responses in the face of higher responses to SWAP and variable anti-cerc responsiveness. Cured not re-exposed patients express very high levels of anti-SEA proliferation. It has recently been seen that those individuals who live in endemic areas and have continued water contact, but are reapeatedly stool-negative (who are presumed to have self-cured or be putatively resistant; endemic normals) are strongly responsive to antigenic extracts, particularly to SEA. Furthermore, our results show that endemic normal individuals have significantly higher IFN gamma production upon PBMC stimulation with schistosome antigens than infected individuals. With the emergence of more studies it is becoming apparent that both the intensity and the prevalence of a given area may influence or shape the general responsiveness of the population under study.

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Publication Dates

  • Publication in this collection
    04 June 2009
  • Date of issue
    1992
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