Amano1010 Amano K, Morita T, Baba M, et al. Effect of Nutritional Support on Terminally Ill Patients With Cancer in a Palliative Care Unit. Am J Hosp Palliat Med. 2012;30(7):730–733. Disponível em: http://journals.sagepub.com/doi/10.1177/1049909112469273 (2012), Japan |
PLC |
63 |
69 (SD: 14) |
Encouragement, snacks and ONS, TPN |
Bedsores, edema and antibiotic therapy |
Andrew1111 Andrew IM, Waterfield K, Hildreth AJ, Kirkpatrick G, Hawkins C. Quantifying the impact of standardized assessment and symptom management tools on symptoms associated with cancer-induced anorexia cachexia syndrome. Palliat Med 2009;23(8):680–688. (2009), UK |
PLC |
40 |
72 (62-81) |
NC |
Early satiation, poor appetite, xerostomia |
Aramaki1212 Aramaki T, Arai Y, Takeuchi Y, et al. A randomized, controlled trial of the efficacy of percutaneous transesophageal gastro-tubing (PTEG) as palliative care for patients with malignant bowel obstruction: the JIVROSG0805 trial. Support Care Cancer. 2019;28(6):2563–2569. Disponível em: http://link.springer.com/10.1007/s00520-019-05066-8 (2019), Japan |
RCT |
39 (15 older adults) |
62 (34-76) |
PEG |
QOL |
Arnold1313 Arnold C, Richter MP. The effect of oral nutritional supplements on head and neck cancer. Int J Radiat Oncol. 1989;16(6):1595–1599. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/0360301689909681 (1989), USA |
PLC |
50 |
64.1 (34-88) |
ONS |
NS |
Baldwin1414 Baldwin C, Spiro A, McGough C, et al. Simple nutritional intervention in patients with advanced cancers of the gastrointestinal tract, non-small cell lung cancers or mesothelioma and weight loss receiving chemotherapy: a randomised controlled trial. J Hum Nutr Diet. 2011;24(5):431–440. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&db=c8h&AN=104680515⟨=pt-br&site=ehost-live (2011), UK |
RCT |
358 |
66.8 (24-88) |
NC, ONS, |
Survival, QOL, NS |
Barber1515 Barber MD, Ross JA, Voss AC, Tisdale MJ, Fearon KCH. The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer. Br J Cancer. 1999;81(1):80–86. Disponível em: http://www.nature.com/articles/6690654 (1999), UK |
QE |
20 |
62 (51-75) |
ONS with fish oil (omega 3) |
Weight loss |
Bouleuc1616 Bouleuc C, Anota A, Cornet C, et al. Impact on Health-Related Quality of Life of Parenteral Nutrition for Patients with Advanced Cancer Cachexia: Results from a Randomized Controlled Trial. Oncologist. 2020;25(5):e843–e851. Disponível em: https://www.embase.com/search/results? subaction=viewrecord&id=L2004547347&from=export (2020), France |
RCT |
111 |
67 (60-72) |
TPN |
QOL, intake, digestive symptoms, weight |
Ching1717 Ching N, Grossi C, Zurawinsky H, et al. Nutritional Deficiencies and Nutritional Support Therapy in Geriatric Cancer Patients. J Am Geriatr Soc. 1979;27(11):491–494. Disponível em: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018608047&doi=10.1111%2Fj.1532-5415.1979.tb01735.x&partnerID=40&md5= acfec2349ebadbcf52dcf1c9826a1cf5 (1979), USA |
QE |
45 |
60-86 |
ONS, EN and TPN |
Hypoalbuminemia |
Cotogni1818 Cotogni P, Carli L De, Passera R, et al. Longitudinal study of quality of life in advanced cancer patients on home parenteral nutrition. Cancer Med. 2017;6(7):1799–1806. Disponível em: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019692432&doi=10.1002%2Fcam4.1111&partnerID=40&md5=1a0285036bb2c23aa0f29b86c9c07115 (2017), Italy |
PLC |
111 |
62 (32-79) |
Home TPN |
QOL |
Crogan1919 Crogan NL. Relieving Drug-Induced Xerostomia With Sorbet. Ann Long Term Care. 2015;23(2):17–21. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&db=c8h&AN=107777911⟨=pt-br&site=ehost-live (2015), USA |
PLC |
22 |
≥ 65 |
Lemon-lime sorbet |
Xerostomia |
Culine2020 Culine S, Chambrier C, Tadmouri A, et al. Home parenteral nutrition improves quality of life and nutritional status in patients with cancer: a French observational multicentre study. Support Care Cancer. 2014;22(7):1867–1874. Disponível em: http://link.springer.com/10.1007/s00520-014-2164-9 (2014), France |
QE |
437 |
63 (SD: 11.4) |
Home TPN |
QOL, NS |
Del Fabbro2121 Fabbro E Del, Hui D, Dalal S, Dev R, Nooruddin ZI, Bruera E. Clinical outcomes and contributors to weight loss in a cancer cachexia clinic. J Palliat Med 2011;14(9):1004–1008. (2011), USA |
RC |
151 |
60 (19-86) |
NC and pharmacological measures |
Weight loss, poor appetite |
Ester2222 Ester M, Culos-Reed SN, Abdul-Razzak A, et al. Feasibility of a multimodal exercise, nutrition, and palliative care intervention in advanced lung cancer. BMC Cancer. 2021;21(1). Disponível em: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101427890&doi=10.1186%2Fs12885-021-07872-y&partnerID=40&md5=bb1ee1d61938539086e84886f0d404f8 (2021), Canada |
QE |
10 |
64.4 (51-83) |
PA, nutrition and symptom control |
QOL, fatigue, low intake, xerostomia |
Fearon2323 Fearon, KCH; Von Meyenfeldt, MF; Moses, AGH; Van Geenen, R; Roy, A; Gouma, DJ; Giacosa, A; Van Gossum, A; Bauer, J; Barber, MD; Aaronson, NK; Voss, AC; Tisdale M. Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial. Gut. 2003;52(10):1479–1486. Disponível em: https://gut.bmj.com/lookup/doi/10.1136/gut.52.10.1479 (2003), UK |
RCT |
200 |
67 |
Omega-3 fatty acid and antioxidants |
Weight, QOL, body composition, intake |
Ha2424 Ha L, Hauge T, Spenning AB, Iversen PO. Individual, nutritional support prevents undernutrition, increases muscle strength and improves QoL among elderly at nutritional risk hospitalized for acute stroke: A randomized, controlled trial. Clin Nutr. 2010;29(5):567–573. Disponível em: http://dx.doi.org/10.1016/j.clnu.2010.01.011 https://doi.org/10.1016/j.clnu.2010.01.0...
(2010), Norway |
RCT |
124 |
78.5 (SD: 7.4) |
SNI |
Malnutrition, weight loss, QOL, strength |
Isenring2525 Isenring EA, Capra S, Bauer JD. Nutrition intervention is beneficial in oncology outpatients receiving radiotherapy to the gastrointestinal or head and neck area. Br J Cancer. 2004;91(3):447–452. Disponível em: http://www.nature.com/articles/6601962 (2004), Australia |
RCT |
60 |
61.9 (SD: 14) |
Early intensive intervention with NC |
Weight, NS, QOL, physical function |
Isenring2626 Isenring EA, Bauer JD, Capra S. Nutrition Support Using the American Dietetic Association Medical Nutrition Therapy Protocol for Radiation Oncology Patients Improves Dietary Intake Compared with Standard Practice. J Am Diet Assoc. 2007;107(3):404–412. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S0002822306026745 (2007), Australia |
RCT |
60 |
61.9 |
Early intensive intervention with NC |
Protein and energy intake |
Lindh2727 Lindh A, Cedermark B, Blomgren H, Wasserman J, Petrini B. Enteral and parenteral nutrition in anorectic patients with advanced gastrointestinal cancer. J Surg Oncol. 1986;33(1):61–65. Disponível em: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022517615&doi=10.1002%2Fjso.2930330117&partnerID=40&md5=55e1af1dd5c9d9e8c4ab459fc5960e47 (1986), Sweden |
QE |
20 |
65 (51-83) |
EN and TPN |
Malnutrition |
Lundholm2828 Lundholm K, Daneryd P, Bosaeus I, Körner U, Lindholm E. Palliative Nutritional Intervention in Addition to Cyclooxygenase and Erythropoietin Treatment for Patients with Malignant Disease: Effects on Survival, Metabolism, and Function: A Randomized Prospective Study. Cancer. 2004;100(9):1967–1977. Disponível em: https://www.embase.com/search/results?subaction=viewrecord&id=L38529575& from=export (2004), Sweden |
RCT |
309 |
68 ± 1 |
ONS and home TPN |
Weight loss |
Ma2929 Ma C-J, Huang C-W, Yeh Y-S, et al. Supplemental home parenteral nutrition improved nutrition status with comparable quality of life in malnourished unresectable/metastatic gastric cancer receiving salvage chemotherapy. Support Care Cancer. 2020;29(4):1977–1988. Disponível em: https://link.springer.com/10.1007/s00520-020-05687-4 (2020), China |
PLC |
50 |
68 (35-88) |
Home TPN |
NS, QOL |
McCann3030 Mccann RM, Hall WJ, Groth Juncker A. Comfort Care for Terminally III Patients: The Appropriate Use of Nutrition and Hydration. JAMA J Am Med Assoc. 1994;272(16):1263–1266. Disponível em: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028110449&doi=10.1001%2Fjama.1994.03520160047041&partnerID=40&md5=01876a8736d40dd7635c3239019d3c4c (1994), USA |
QE |
10 |
74.7 (44-92) |
Small amounts of food/ fluids |
Experience of hunger and thirst |
Persson3131 Persson CR, Johansson BBK, Sjoden P-O, Glimelius BLG. A Randomized Study of Nutritional Support in Patients With Colorectal and Gastric Cancer. Nutr Cancer. 2002;42(1):48–58. Disponível em: http://www.tandfonline.com/doi/abs/10.1207/S15327914NC421_7 (2002), Sweden |
RCT |
137 |
69 (48-89) |
SNI |
Weight, intake, QOL and survival |
Ravasco3232 Ravasco P, Monteiro-Grillo I, Marques Vidal P, Camilo ME. Impact of nutrition on outcome: A prospective randomized controlled trial in patients with head and neck cancer undergoing radiotherapy. Head Neck. 2005;27(8):659–668. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/hed.20221 (2005), Portugal |
RCT |
75 |
60 (36-79) |
NC and ONS |
NS, morbidity and QOL |
Ruggeri3333 Ruggeri E, Giannantonio M, Agostini F, Ostan R, Pironi L, Pannuti R. Home artificial nutrition in palliative care cancer patients: Impact on survival and performance status. Clin Nutr. 2020;39(11):3346–3353. Disponível em: https://doi.org/10.1016/j.clnu.2020.02.021 https://doi.org/10.1016/j.clnu.2020.02.0...
(2020), Italy |
RC |
969 |
65.7 (±12.7) |
Home artificial nutrition |
Malnutrition |
Senesse3434 Senesse P, Tadmouri A, Culine S, et al. A Prospective Observational Study Assessing Home Parenteral Nutrition in Patients With Gastrointestinal Cancer: Benefits for Quality of Life. J Pain Symptom Manage. 2015;49(2):183-191.e2. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S0885392414003108 (2015), France |
QE |
370 |
64.5 (SD: 11) |
TPN |
QOL and NS. |
Silvers3535 Silvers MA, Savva J, Huggins CE, Truby H, Haines T. Potential benefits of early nutritional intervention in adults with upper gastrointestinal cancer: a pilot randomised trial. Support Care Cancer. 2014;22(11):3035–3044. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&db=c8h&AN=109758112⟨=pt-br&site=ehost-live (2014), Australia |
RCT |
21 |
72 (SD:12) |
NC aimed at symptoms and NOS |
NS, Symptoms control |