Hypertension and maternal urinary tract infection and the metabolic conditions of preterm infants

Bavaresco, Talita; Menolli, Rafael Andrade; Frizon, Bruna Juliana Zancanaro; Viera, Claudia Silveira; Conterno, Julia Reis; Guimarães, Ana Tereza Bittencourt; Grassiolli, Sabrina

doi:10.1590/0034-7167-2017-0179

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Revista Brasileira de Enfermagem

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ORIGINAL ARTICLE • Rev. Bras. Enferm. 72 (suppl 3) • Dec 2019 • https://doi.org/10.1590/0034-7167-2017-0179 copy

Hypertension and maternal urinary tract infection and the metabolic conditions of preterm infants

Hipertensión e infección del tracto urinario en madres y condiciones metabólicas de prematuros

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

Objective:

The present study evaluated the anthropometric and metabolic profiles of preterm infants (PT) born from mothers with urinary tract infections (UTI) and mothers with hypertensive disorders (HD).

Method:

This was a longitudinal prospective study conducted between May 2015 and August 2016. First, 59 mothers with premature birth were included; after excluding 29 mothers, two subgroups were created: UTI-mothers (n=12) and HD-mothers (n=18). The anthropometric and metabolic variables of mothers and their respective PT were analyzed at birth and at 6 months of corrected age (CA).

Results:

Plasma triglyceride levels were higher among HD-mothers and their respective PT in comparison with UTI-mothers and their PT at 6 m of CA.

Conclusion:

Plasma triglyceride level is an important metabolic biomarker in HD-mothers resulting in higher triglyceride levels among PT at the CA of 6 m, suggesting an early programming effect of maternal hypertension.

Descriptors:
Premature Birth; Hypertension; Urinary Infection; Metabolic Programming; Mothers

	HD-Mothers (n=12)	UTI-Mothers (n=18)	p value
Age (years)	26.92 ± 5.334	24.72 ± 5.432	0.283
Body Weight^# # Body weight and BMI were obtained pre-pregnancy. BMI classification was based on the WHO classification(2). (Kg)	70.34 ± 16.89	60.43 ± 12.36	0.073
	n (%)
BMI^#2 World Health Organization (WHO). Obesity: preventing and managing the global epidemic. Report of a World Health Organization Consultation [Internet]. Geneva: WHO; 2000 [cited 2017 Jun 5]. Available from: https://www.who.int/nutrition/publications/obesity/WHO_TRS_894/en/ https://www.who.int/nutrition/publicatio...
Underweight	0	2 (11.11)	0.345^* * Monte Carlo Permutational Test; UTI = urinary tract infections; HD = hypertensive disorders.
Normal	4 (33.33)	10 (55.60)
Overweight	5 (41.67)	4 (22.22)
Obese	3 (25.00)	2 (11.11)
Ethnicity
White	11 (91.67)	16 (88.89)	0.804
Nonwhite	1 (8.33)	2 (11.11)
Maternal schooling
Zero - 4 years	0	2 (11.11)	0.335^* * Monte Carlo Permutational Test; UTI = urinary tract infections; HD = hypertensive disorders.
Five - 9 years	1 (8.33)	4 (22.22)
Ten or more years	11 (91.67)	12 (66.67)

	PT of HD-Mothers (n=12)	PT of UTI-Mothers (n=21)	p value
Body weight^* * t test (g)
At birth	1373 ± 496.60	1570 ± 589.90	0.349
At 6 m of CA	6714 ± 283.30	7155 ± 292.60	0.0003
Height^* * t test (cm)
At birth	38.79 ± 1.06	39.38 ± 0.90	0.112
At 6 m of CA	65.20 ± 1.033	65.12 ± 0.78	0.811
Head circumference^* * t test (cm)
At birth	27.93 ± 0.54	28.15 ± 0.58	0.305
At 6 m of CA	42.53 ± 0.42	42.60 ± 0.33	0.614
Gestational age^* * t test (weeks)	30.58 ± 0.60	30.14 ± 0.60	0.059
Sex^ Chi-squared test; p<0.05); PT = preterm; UTI = urinary tract infections; HD = hypertensive disorders.	n (%)	n (%)
Male	6 (50)	10 (47.62)	0.895
Female	6 (50)	11 (52.38)

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[1] Corresponding Author: Sabrina Grassiolli. E-mail: sgrassiolli@gmail.com