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Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

Controle glicêmico e produção de citocinas em pacientes diabéticos com doença periodontal crônica

Mayra Moura FRANCO Mariana Mader Miranda MORAES Poliana Mendes DUARTE Marcelo Henrique NAPIMOGA Bruno Braga BENATTI About the authors


To evaluate the association of glycemic control and cytokine production in type 2 diabetic subjects with chronic periodontitis.


Gingival biopsies were performed in 40 patients, divided into four groups: systemically healthy subjects without periodontal disease (S); systemically healthy patients with chronic periodontitis (P); patients with well-controlled type 2 diabetes mellitus (DM) with chronic periodontitis (C); poorly controlled type 2 diabetes mellitus with chronic periodontitis (D). The production of interleukin (IL) -4, -6, -10, -17 and interferon (IFN) -g was quantified by ELISA.


The production of IL-4, IL-10, IL-17 and INF-g was higher on group D when compared to other groups (p <0.05), which in turn were similar (p ³0.05). In addition, there was no difference in the production of IL-6 in any of the evaluated groups (p³0.05).


Were observed significantly elevated levels of pro-inflammatory and anti-inflammatory cytokines in patients with poorly controlled type 2 diabetes and chronic periodontitis, demonstrating that glycemic control may be associated to the immune inflammatory response of sites with chronic periodontitis.

Chronic periodontitis; Cytokines; Diabetes Mellitus; Inflammation

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