Factors associated to chronic kidney disease in people living with HIV/AIDS* * Paper extracted from master’s thesis “Risk factors for chronic kidney disease in people living with HIV/aids”, presented to Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, PAHO/WHO Collaborating Centre at the Nursing Research Development, Ribeirão Preto, SP, Brazil. The presente study was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Finance Code 001, Brazil.

Priscila Silva Pontes Antonio Ruffino-Netto Luciana Kusumota Christefany Régia Braz Costa Elucir Gir Renata Karina Reis About the authors

Objective:

to analyze the factors associated to chronic kidney disease in people living with HIV (PLHIV).

Method:

a paired case-control study (4 controls for each case) carried out in a specialized care service in the Southeastern of Brazil, by analyzing PLHIV medical records. The sample consisted of 85 participants, corresponding to 17 cases and 68 controls. Pearson’s chi-square test (Χ2) and Fisher’s exact test, logistic regression, Odds Ratio (OR), 95% Confidence Interval (CI) and p<0.05 were used. SPSS version 25.0 and R Core Team, 2018 version 3.5.1 were used.

Results:

the factors associated with chronic kidney disease identified in this study were the following: presence of Systemic Arterial Hypertension [OR=5.8, CI (95%)=1.84-18.42, p=0.001] and use of nephrotoxic anti-retrovirals in the previous therapeutic regimen [OR=3.3, CI (95%)=1.105-10.221, p=0.028]. On the other hand, age below 40 years old [OR: 0.122, CI (95%)=0.015-0.981, p=0.022] was identified as a protective factor.

Conclusion:

the PLHIV under study have multi-factorial exposure associated with chronic kidney disease. However, knowing these factors helps to identify the existing risks and/or renal dysfunction, in addition to supporting the clinical decision of the health professionals who directly assist them.

Descriptors:
HIV; Renal Insufficiency, Chronic; Glomerular Filtration Rate; Antiretroviral Therapy, Highly Active; Risk Factors; Comorbidity


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