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Short Communication • Rev. Soc. Bras. Med. Trop. 54 • 2021 • https://doi.org/10.1590/0037-8682-0146-2020   copy

Selective activity of diselenides against Aedes aegypti (Diptera: Culicidae) larvae

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION:

Aedes aegypti (L.) is the major vector of arboviruses that causes serious public health concerns in tropical and subtropical countries.

METHODS:

We examined the larvicidal activity of 1,2-diphenyldiselenide [(PhSe)2] and 1,2-bis(4-chlorophenyl) diselenide [(p-ClPhSe)2] and determine its toxicity to different non-target organisms.

RESULTS:

(PhSe)2 and (p-ClPhSe)2 killed Ae. aegypti L3 larvae with LC50/24h values of 65.63 µM (20.48 mg/L) and 355.19 µM (135.33 mg/L), respectively. (PhSe)2 was not toxic to the four model organisms.

CONCLUSIONS:

(PhSe)2 is a larvicidal compound with selective action against Ae. aegypti larvae. The mechanisms of action of (PhSe)2 under field conditions remain to be investigated.

Keywords:
Selenium; 1,2-diphenyldiselenide; 1,2-bis(4-chlorophenyl) diselenide; Caenorhabditis elegans; Chlorella vulgaris; Galleria mellonela

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