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(Updated: 2023/08/30)

About the journal


Basic information


The Memórias do Instituto Oswaldo Cruz (MIOC) is a multidisciplinary journal which publishes original research on microbes and their vectors causing human infections. It welcomes basic and applied research in biochemistry, immunology, molecular and cell biology, physiology, pharmacology and genetics related to these subjects.

The journal adhered to continuous publication (CP) mode. Occasionally papers presented at symposia or congresses are published in a format of a series of independent articles.

The following article formats are accepted for publication: Research Articles e Review and Perspectives. Review articles are considered only by invitation from an editorial board member. All other article formats will be submitted to external peer review. Acceptance will be based on scientific content and presentation of the material, and compliance with the good publication practices, as recommended by COPE.

Submission of a paper to the MIOC implies that is has not previously been published, or that it is not being considered for publication in a scientific journal elsewhere (except in an abstract form). 

Manuscripts that were submitted to a recognized preprint server such as BioRxiv or PeerJ will not be considered as prior publication, and are welcome in MIOC.




Indexed in


Memórias do Instituto Oswaldo Cruz is covered by:

  • Biological Abstracts
  • Chemical Abstracts Service - CAS
  • Current Contents - Life Sciences
  • Entomology Abstracts
  • Excerpta Medica
  • Fish and Fisheries Worldwide, Aquatic Biology, Aquaculture and Fisheries Resources - Nisc’s FISHLIT
  • Helminthological Abstracts
  • Index Medicus - Medline - PubMed
  • Info-Latinoamerica
  • Institute for Scientific Information - ISI
  • Literatura Latino-Americana - Lilacs
  • Microbiology Abstracts
  • Protozoological Abstracts
  • Scientific Electronic Library Online - SciELO
  • Science Citation Index - SCI
  • Sociedad Iberoamericana de Información Científica - SIIC
  • Tropical Diseases Bulletin
  • Wildlife Review
  • Zoological Record (Thomson Zoological Ltd)


Intellectual property


All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.










The publication of the journal is supported by:

  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes)



Editorial Board





Associated Editors



Editorial office




Instructions to authors


Scope and policy


The Memórias' content is freely accessible to readers and no publication fees are charged to authors. The Memórias do Instituto Oswaldo Cruz has decided to simplify the requirements regarding the format of submitted manuscripts. From now on, all manuscripts  may be submitted in any text format as long as the common subdivision of scientific articles are followed, e.g. introduction, materials and methods, results, discussion and references. For Reviews, Perspectives and similar  articles, authors may use the sections that best suit the structure and content of the proposed manuscript. All manuscripts should  contain, besides the title and abstract, full details of authors and institutions, acknowledgements of any technical or financial assistance and authors must disclose any conflict of interest related to their research work. This flexible text format will be used for the initial analysis and peer review. the manuscript is accepted, authors will be requested to edit the text in accordance with the publication style of the Memorias.

All authors should declare any competing interest, financial or not-financial that might have influenced their manuscript. Authors from pharmaceutical companies, or other commercial organizations that sponsor clinical trials, should declare these as competing interests on submission and ensure the adherence to the Good Publication Practice guidelines for pharmaceutical companies (GPP3).

Upon acceptance, the manuscript should be arranged in the following format:

The manuscript should be prepared using standard word processing software and should be printed (font size 12) double-spaced throughout the text, figure captions, and references (must be up to 30 references), with margins of at least 3 cm. The figures should come in the extension tiff, with a minimum resolution of 300 dpi. Tables and legends to figures must be submitted all together in a single file. Figures, must be uploaded separately as supplementary file.

Running title: not required

Title: with up to 250 characters

Author's names: without titles or graduations

Institutional affiliations: full address of the corresponding author only

Abstracts: Provide an abstract up to 200 words (100 words in case of short communications, technical notes or reviews). Abstracts of original articles should be structured into 5 sections as follows: BACKGROUND, OBJECTIVES, METHODS, FINDINGS and MAIN CONCLUSIONS, each section addressing respectively the problem, the aim of the study, the main methodological approach, the most important findings and the conclusions of the study.

Key words: 3-6 items must be provided. Terms from the Medical Subject Headings (Mesh) list of Index Medicus should be used.

Sponsorships: indicating the sources of financial support and change of address.

Introduction: should set the purpose of the study, give a brief summary (not a review) of previous relevant works, and state what new advance has been made in the investigation. It should not include data or conclusions from the work being reported.

Materials and Methods: should briefly give clear and sufficient information to permit the study to be repeated by others. Standard techniques need only be referenced.

Ethics: when reporting experiments on human subjects, indicate whether the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional or regional) and with the Helsinki Declaration of 1975, as revised in 1983. When reporting experiments on animals, indicate whether the institution's or a national research council's guide for, or any national law on the care and use of laboratory animals was followed.

Results: should be a concise account of the new information discovered, with the least personal judgement. Do not repeat in text all the data in the tables and illustrations.

In case of describing New Species, should follow:

Name of the new species, authors (when it is the case), sp. nov., (Figs x-y)

[Ex: An. (Nyssorhynchusatacamensis González and Sallum, sp. nov. (Figs 1-4)]

Previous reference to the new species (when it is the case)

[Ex: An. pictipennis of Rueda et al. (2008): 448.]

Diagnosis (or Description; all stages are described);

Type host (when it is the case);

Site of Infection (when it is the case);


Type data and depository;

Other material examined (when it is the case);


Host-parasite data (such prevalence and other important data, when it is the same case);


Taxonomic discussion (or simply DISCUSSION as internal title).

Discussion: should be limited to the significance of the new information and relate the new findings to existing knowledge. Only unavoidable citations should be included.

Acknowledgements: should be short and concise, and restricted to those absolutely necessary.

Author's contribution: During article submission process, authors are encouraged to detail each of their contribution to the work.





Must be accurate. Only citations that appear in the text should be referenced. Unpublished papers, unless accepted for publication, should not be cited. Work accepted for publication should be referred to as "in press" and a letter of acceptance of the journal must be provided. Unpublished data should only be cited in the text as "unpublished observations", and a letter of permission from the author must be provided. The references at the end of the paper should be listed in numerical order, and in the same order in which they are cited in text.


To assure your references is published as requested, please keep your list format up to 30 references and send archives without Mendeley Hyperlink or similar. References created with edition marks will cause improper corrections during editing process, causing delays.


Should be abbreviated according to the style used in the Index Medicus. 

A number is allocated to a source in the order in which it is cited in the text. If the source is referred to again, the same number is used.

Use superscript Arabic numerals (1,2,3,4,5,6,7,8,9) inside of curved brackets.

List each reference number separated by comma, or by dash for a sequence of consecutive numbers. There should be no spaces between commas or dashes. Ex.: (1,3,6-8).

The in-text citation is placed immediately after the text, which refers to the source being cited.

Ex.: These observations were consistent with those made in Venezuela, Brazil, and British Guyana.(1-4)

The author’s name can also be included in the text.

Ex.: The method for quantifying egg viability was adapted from Farnesi et al.(1)


Journal article

Chagas C, Villela E. Forma cardíaca da tripanosomiase americana. Mem Inst Oswaldo Cruz. 1922; 14(1): 05-61.

Book and Thesis 

Forattini OP. Entomologia médica. Psychodidae, Phlebotominae, Leishmaniose, Bartonelose. Vol. IV. São Paulo: Edgard Blucher; 1973. 658 pp.

Morel CM. Genes and antigens of parasites. A laboratory manual. 2nd ed. Rio de Janeiro: Fiocruz; 1983. xxii + 580 pp.

Mello-Silva CC. Controle alternativo e alterações fisiológicas em Biomphalaria glabrata (Say, 1818), hospedeiro intermediário de Schistosoma mansoni Sambom, 1907 pela ação do látex de Euphorbia splendens var. hislopii N.E.B (Euphorbiaceae) [PhD Thesis]. Seropédica: Universidade Federal Rural do Rio de Janeiro; 2005. 85 pp.

Chapter in book

Cruz OG. The prophylaxis of malaria in central and southern Brasil. In: Ross R, The prevention of malaria. London: John Murray; 1911. 390-8.

Journal article on the Internet

Abood S. Quality improvement initiative in nursing homes: the ANA acts in an advisory role. Am J Nurs [Internet]. 2002 [cited 2002 Aug 12]; 102(6). Available from:

Monograph on the Internet

Foley KM, Gelband H, editors. Improving palliative care for cancer [monograph] [Internet]. Washington: National Academy Press; 2001 [cited 2002 Jul 9]. Available from:

Homepage/Web site [homepage on the Internet]. New York: Association of Cancer Online Resources, Inc.; c2000-01 [updated 2002 May 16; cited 2002 Jul 9]. Available from:

Part of a homepage/Web site

American Medical Association [homepage on the Internet]. Chicago: The Association; c1995-2002 [updated 2001 Aug 23; cited 2002 Aug 12]. AMA Office of Group Practice Liaison; [about 2 screens]. Available from:


Open database

Who's Certified [database on the Internet]. Evanston (IL): The American Board of Medical Specialists. c2000 - [cited 2001 Mar 8]. Available from:

Closed database

Jablonski S. Online Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes [Internet]. Bethesda (MD): National Library of Medicine (US). c1999 [updated 2001 Nov 20; cited 2002 Aug 12]. Available from:

Part of a database on the Internet

MeSH Browser [Internet]. Bethesda (MD): National Library of Medicine (US); 2002. Meta-analysis; 2003 [cited 2003 Jun 10]; [about 3 p.]. Available from:



Figures and tables



Figures: presented in tiff format with a minimum of 300 dpi and photographs must be sharply focused, well contrasted, and if mounted onto a plate, the figures should be numbered consecutively with Arabic numbers. Magnification must be indicated by a line or bar in the figure, and referenced, if necessary in the caption (e.g., bar = 1 mm). Plates and line figures should either fit one column (8 cm) or the full width (16.5 cm) of the page and should be shorter than the page length to allow inclusion of the legend. Letters and numbers on figures should be of a legible size upon reduction or printing. A colour photograph illustrates the cover of each issue of the Journal and authors are invited to submit illustrations with legends from their manuscript for consideration for the cover.

Tables: should supplement, not duplicate, the text and should be numbered with Roman numerals. A short descriptive title should appear above each table, with any explanations or footnotes (identified with a, b, c, etc.) below.

Supplemental material: refers to files related to a specific article, which authors supply for publication alongside their article. They should generally be additional pieces to the article that could not be included in the issue, such as appendices, spreadsheets, tables, figures that is impossible to produce within the article. These files will be sent to reviewers for peer review, along with the article’s main files.

We recommend that Supplementary files uploaded into the system be in the following format:
- Excel or any spreadsheet should be uploaded in PDF format or provide link to access files
- Supplementary figures with five or more pieces please provide a PDF file with as many figures as possible.

We recommend providing small size files for quick download purposes.



Article format


Review: Papers in “review” format are accepted only by means of invitations made by the editor or associated editors.

Technical Notes: Technical Notes should communicate rapidly single novel techniques or original technical advances. The entire note should occupy no more than three printed pages including figures and/or tables (it means around 10 double-spaced typed Word file maximum). The text must not be not divided into sections. Therefore, the state of art must be very briefly presented; results must be rapidly presented and discussed at a time. Complementary tables and figures may be published as supplementary data. References must be limited to few essential ones and cited at the end of the note, using the same format as in full papers. A brief summary and three key words must be provided.

Short communications: should communicate rapidly single results or techniques. They should occupy no more than three printed pages including figures and/or tables. They should not contain excessive references. References should be cited at the end of the paper using the same format as in full papers. A brief summary and three key words must be provided.

Alternative format: manuscripts may be submitted following the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals" produced by the International Committee of Medical Journal Editors also known as the Vancouver Style. In this case, authors should follow the guidelines in the fifth edition (Annals of Internal Medicine 1997; 126: 36-47, or at the website and will be responsible for modifying the manuscript where it differs from the instructions given here, if the manuscript is accepted for publication. 
Authors should also follow the Uniform Requirements for any guidelines that are omitted in these Instructions.

In case of clinical trials it’s mandatory to inform the registration number of the REBEC platform.

A statement that the data/results of the manuscript are not plagiarism and have not been published elsewhere.


Page charges: there will be no page charges.

Proofs: one set of page proofs will be supplied for the author to check for typesetting accuracy, to be returned by the stipulated date. No changes to the original manuscript will be allowed at this stage.





MIOC adheres to the criteria established by the International Committee of Medical Journal Editors (ICMJE). As such, authorship should fulfill all 4 criteria: 1) conception and design or acquisition, analysis or interpretation of data for the work; 2) drafting the work or revising it critically; 3) approval of the final version AND 4) accountability for all aspects of the work. Contributors that do not meet the criteria for authorship should be listed in the Acknowledgement section.

Each of the authors must describe their role in the manuscript. The corresponding author is responsible for ensuring that all authors have agreed to the submission of the manuscript, but all should take responsibility for its content. Only one of the authors should be the corresponding but more than one can be identified as ‘Equal first authors’. 

The list and order of authors should be carefully considered when submitting the manuscript. Any change (addition, deletion or rearrangement of authors) during the evaluation process must have a reasonable and strong argument in addition to a written agreement of all previous authors. Authorship changes are not allowed after acceptance of the manuscript.



Ethical Guidelines and Research Integrity


MIOC is a member of the Commission on Publication Ethics (COPE), and fully complies with the high standards established in the Code of Conduct and Best Practice Guidelines for Journal Editors.

Approval by an appropriate Ethics Committee is mandatory for any research involving human subjects or any human material. The Authors should include in the manuscript the name of the ethics committee and the reference number of the approved project. All authors are required to follow the ICMJE requirements. Clinical trials or randomized controlled trials must have been registered in a primary register of the WHO International Clinical Trials Registry Platform. 

Assays using animals must conform the principles of animal welfare in experimental science. Reference must be made to principles of laboratory animal care or similar regulations and to approval by the local ethical committee. Please provide the permit numbers and the name of the Ethical Committee. 

All authors must ensure the reported researches are not the result of misconduct such as data fabrication, falsification, plagiarism or duplication. Please refer to Singapore Statement. In case of confirmed research misconduct, we will issue a retraction notice to correct the scientific record. We inform that a paper submitted to MIOC undergoes a process using the Ithenticate plagiarism checker software to prevent professional plagiarism and other forms of scholarly misconduct. 

Responsibility for the accuracy of the material in the manuscript, including bibliographic citations, lies entirely with the authors.

We recommend the use of the checklists below to make sure that the work reported was performed according to good practice standards (Equator Network):

a. CONSORT for randomised trials; 
b. STARD for studies on diagnostic studies; 
c. PRISMA for systematic reviews and meta-analyses; 
d. ARRIVE for pre-clinical animal studies.

In order to ensure the good quality and reproducibility, all resources used in the work should contain precise identification. We suggest authors to use identifiers available for antibodies, organisms or computational tools at the Resource Identification Initiative

Quantitative studies using PCR should follow the MIQE guidelines

Any microorganism or cell line should be clearly identified including the source/collection, when and from where it was obtained, and if it was authenticated. Human cell lines should have been recently tested for mycoplasma contamination.



Evaluation Workflow


All manuscripts submitted to MIOC are firstly evaluated by the editorial board, whose decision is entirely based upon the content and relevance of the manuscript. This initial screening process results in three outcomes:

1. The manuscript is not within the scope of the journal. Action: manuscript will be immediately returned to author(s).

2. The manuscript is considered as of ‘low priority’ for publishing in Memorias (eg, lack of novelty, no relevance, too specific, too technical). Action: manuscript will be immediately returned to author(s).

3. The manuscript is considered ‘potentially interesting for publication’. Action: i) editorial board performs a ‘compliance with publishing ethics”, e.g., plagiarism detection, duplication, manipulation. In any of these conditions, manuscript is rejected and returned to authors; ii) editorial board assigns a handling editor to manage the editorial procedure of that manuscript, who will invite external peer-reviewers (at least two), and will be responsible to communicating and following up the comments and suggestions from reviewers to authors. 

4. Handling editor final decision: if recommendation is for ‘not to publish’, editorial board views the decision and communicates both authors and reviewers immediately. In case of ‘accept for publication’, editorial board confirms the decision, and both authors and reviewers will be communicated of such decision.

5. Handling editor leaves the editorial procedure and the accepted manuscript is transferred to editing center (format text, figures, data, references etc).

At any time and at its exclusive discretion, the editorial board may interrupt the procedure if any sign of misconduct is detected. No authorship change is allowed after the manuscript is accepted for publication.


All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License 4.0. This means that authors give full permission to anyone to share and to adapt the content of the article as long as the original authors and source is cited.


The data that generated the manuscript must be open and publicly available whenever demanded. In case of research involving human subjects, data should be de-identified Information concerning gene sequences reported in the manuscript, must have its public bank accession number mentioned in the manuscript (e.g. GeneBank).





Submitted papers must be written in English. Any submission written in a language that is not English will be returned to the authors. English of low quality is a major cause of delay in publication and we strongly advise authors with English as a foreign language to have their manuscripts checked by someone with English as a first language, preferably a scientist. 



Open Access Publishing


Memórias do Instituto Oswaldo Cruz is a journal with full commitment to open access. As a journal entirely supported by funding from Brazilian public bodies, we strive to guarantee that all information published in our pages:  

a. is freely accessible to every reader at no charge; 

b. reaches the maximum visibility as possible; 

c. is in compliance with good practices for science publishing;

d. present no barrier to content dissemination. 

This effort also includes a commitment to use the appropriate technological structure to assure that the articles and any intellectual content we publish here be available all the times for both authors and readers, regardless of geographic origin, nationality or gender. MIOC also attempts to get in pace with international guidelines promoting the free access to science content and best publishing practices.  As such, MIOC encourages researchers to share their work in a preprint server.





Instituto Oswaldo Cruz, Ministério da Saúde Av. Brasil, 4365 - Pavilhão Mourisco, Manguinhos, 21040-900 Rio de Janeiro RJ Brazil, Tel.: (55 21) 2562-1222, Fax: (55 21) 2562 1220 - Rio de Janeiro - RJ - Brazil