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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.36 no.5 São Paulo Sept./Oct. 1994

https://doi.org/10.1590/S0036-46651994000500012 

CASE REPORT

 

Aspergillosis in immunocompromised children acute myeloid leukemia and bone marrow aplasia. Report of two cases

 

Aspergilose em crianças imunocomprometidas com leucemia mielóide aguda e aplasta de medula óssea. Registro de 2 casos

 

 

Maria Zilda de AquinoI; Alberto BrasacinerI; Lilian Maria CristófaniI; Paulo Taufic MalufI; Vicente Odone FilhoI; Heloisa Helena de Souza MarquesI; Elisabeth Maria Heins-VaccariII; Carlos da Silva LacazII; Natalina Takahashi de MeloII

ICentro de Onco-Hematologia do Instituto da Criança do Hospital das Clínicas de São Paulo, São Paulo, S.P., Brasil
IILaboratórios de Micologia Médica do Instituto de Medicina Tropical de São Paulo e do LIM-53 HC-FMUSP, São Paulo, S.P., Brasil

Correspondence to

 

 


SUMMARY

Two cases of Aspergillosis in immunocompromised children are reported. Both were caused by Aspergillns flavus. Early diagnosis and treatment led to the remission of the process. One patient had acute myeloid leukemia; the fungus was isolated from the blood. The other patient with bone marrow aplasia, presented an invasive aspergillosis of the paranasal sinuses with dissemination of fungal infection; the diagnosis was obtained by histology and culture of biopsied tissue from a palatal ulceration.

Keywords: Aspergillosis; Aspergillus flavus; Leukemia; Bone marrow aplasia.


RESUMO

No presente trabalho são registrados dois casos de aspergilose em crianças imunocomprometidas. O estudo micológico completo identificou Aspergillus flavus como agente dos dois processos. A presença cada vez mais frequente da aspergilose invasiva deve-se ao número crescente de pacientes imunocomprometidos, muitos com hemopatias graves submetidos à quimioterapia. O diagnóstico precoce em um dos casos possibilitou remissão do processo.
Tratava-se de paciente com leucemia mielóide aguda, tendo sido isolado o fungo do sangue circulante. O segundo caso evoluiu para óbito, com infecção fúngica generalizada.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

ACKNOWLEDGEMENTS

Creusa Paes Siqueira for typing the manuscript.

 

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Correspondence to:
Prof. Carlos da Silva Lacaz
Instituto de Med. Trop. São Paulo
Av. Dr. Enéas de Carvalho Aguiar 470
05403-000 São Paulo, SP, Brasil

Recebido para publicação em 10/02/1994.
Aceito para publicação em 04/07/1994.

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