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Dementia & Neuropsychologia

Print version ISSN 1980-5764

Dement. neuropsychol. vol.1 no.2 São Paulo Apr./June 2007

https://doi.org/10.1590/s1980-57642008dn10200008 

Original Articles

Category verbal fluency performance may be impaired in amnestic mild cognitive impairment

A fluência verbal para categoria pode estar alterada no comprometimento cognitivo leve amnéstico

Márcio Luiz Figueredo Balthazar 1  

Fernando Cendes 2  

Benito Pereira Damasceno 3  

1Postgraduate Neurologist.

2Associate Professor.

3Professor, Department of Neurology, Medical School, State University of Campinas - SP, Brazil.


Abstract

To study category verbal fluency (VF) for animals in patients with amnestic mild cognitive impairment (aMCI), mild Alzheimer disease (AD) and normal controls.

Method:

Fifteen mild AD, 15 aMCI, and 15 normal control subjects were included. Diagnosis of AD was based on DSM-IV and NINCDS-ADRDA criteria, while aMCI was based on the criteria of the International Working Group on Mild Cognitive Impairment, using CDR 0.5 for aMCI and CDR 1 for mild AD. All subjects underwent testing of category VF for animals, lexical semantic function (Boston Naming-BNT, CAMCOG Similarities item), WAIS-R forward and backward digit span, Rey Auditory Verbal Learning (RAVLT), Mini-Mental Status Examination (MMSE), and other task relevant functions such as visual perception, attention, and mood state (with Cornell Scale for Depression in Dementia). Data analysis used ANOVA and a post-hoc Tukey test for intergroup comparisons, and Pearson's coefficient for correlations of memory and FV tests with other task relevant functions (statistical significance level was p<0.05).

Results:

aMCI patients had lower performance than controls on category VF for animals and on the backward digit span subtest of WAIS-R but higher scores compared with mild AD patients. Mild AD patients scored significantly worse than aMCI and controls across all tests.

Conclusion:

aMCI patients may have poor performance in some non-memory tests, specifically category VF for animals in our study, where this could be attributable to the influence of working memory.

Key Words: verbal fluency; mild cognitive impairment; Alzheimer disease; neuropsychological tests.

Resumo

Estudar a fluência verbal (FV) para a categoria animais no comprometimento cognitivo leve amnéstico (aCCL), doença de Alzheimer (DA) leve e controles normais.

Método:

Incluímos 15 pacientes com DA leve, 15 com aCCL e 15 controles normais, usando os critérios DSM-IV, NINCDS-ADRDA e CDR 1 para DA, e os do International Working Group on Mild Cognitive Impairment, e CDR 0,5 para aCCL. Todos os sujeitos passaram por avaliação da FV para a categoria animais, função léxico-semântica (Teste de nomeação de Boston - TNB, item de Similaridades do CAMCOG), extensão de dígitos direto e indireto do WAIS-R, aprendizado auditivo-verbal de Rey (TAAVR), Mini-Exame do Estado Mental (MEEM), e de outras funções (contraprovas) capazes de influenciar nestes testes, como percepção visual, atenção e estado de humor (este com a Escala Cornell para Depressão em Demência). A análise dos dados usou o teste de análise de variância (ANOVA) seguido do teste de Tukey post hoc para comparações entre os grupos e o coeficiente de Pearson para correlação entre testes e contraprovas (nível de significância p<0,05).

Resultados:

Os pacientes com aCCL tiveram performance inferior à dos controles nos testes de FV para animais e na extensão de dígitos indireta do WAIS-R. Pacientes com DA leve tiveram performance inferior à de sujeitos com aCCL e controles em todos os testes.

Conclusão:

Pacientes com aCCL tiveram desempenho rebaixado em testes de fluência verbal para animais, o que pode ter sido influenciado pela memória operacional.

Palavras-chave: fluência verbal; comprometimento cognitivo leve; doença de Alzheimer; testes neuropsicológicos.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

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Dr. Benito P. Damasceno - Department of Neurology, Medical School, State University of Campinas - Box 6111 - 13083-970 Campinas SP - Brazil. E-mail: damascen@unicamp.br.

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