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Capillary electromigration techniques can be understood as the ones used to separate neutral compounds, solvated ions and ionized species, considering the differentiated migration among them when an electrical field is applied within a capillary column filled with a background electrolyte. Several existing capillary electrophoresis setups provide the possibility of developing reliable quantitative assays of inorganic ions, organic acids, fatty acids, amino acids, carbohydrates, nucleic acids, proteins, hormones, vitamins, macromolecules, and more. Therefore, given the chemical complexity of bodily fluid matrices, capillary electrophoresis (CE) and its variations present themselves as an advantageous strategy for enhancing traditional clinical diagnostic methods and for the development of new ones. The recent advances in the study of the human metabolome associated with technological improvements towards medical applications make CE a very useful and versatile technique for clinical laboratory assays. Within this context, this review has the purpose of presenting some traditional methods used for exams of blood, urine, saliva, feces, and sweat, and how CE can be implemented as a real alternative to enable faster, automated, and cost-effective analysis with a comprehensive perspective that shall result in better diagnostic possibilities for patients, being a powerful tool for helping physicians on the precision medicine achievements. compounds species electrolyte acids carbohydrates proteins hormones vitamins macromolecules more Therefore matrices (CE context blood urine saliva feces sweat faster automated costeffective cost effective patients achievements

https://doi.org/10.21577/0103-5053.20230096

Comparison of tranexamic acid and stapling line reinforcement in laparoscopic sleeve gastrectomy in postoperative bleeding outcomes
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Brito, Roger Moura de

; Oliveira, Caio Marcio Barros de

; Moura, Ed Carlos Rey

; Campelo, Giuliano Peixoto

; Lima, Roclides Castro de

; Servin, Elizabeth Teixeira Noguera

; Gomes, Lyvia Maria Rodrigues de Sousa

; Fe, Ciro Sousa de Moura

; Oliveira, Eduardo José Silva Gomes de

; Leal, Plínio da Cunha

Brazilian Journal of Anesthesiology

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may 2023, Volume 73 N. 3 Pages 361 - 363

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.bjane.2022.10.006

Violência doméstica em professores da rede pública estadual durante a pandemia da COVID-19
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Bicalho, Ana Clara Santos

; Santos, Ana Júlia Castro

; Silva, Gabriela de Oliveira Maciel

; Costa, Laila Santos da

; Oliveira, Nathália Gomes de

; Nascimento, Talita Santos

; Silva, Rosângela Ramos Veloso

; Brito, Maria Fernanda Santos Figueiredo

; Pinho, Lucinéia de

Jornal Brasileiro de Psiquiatria

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mar 2023, Volume 72 N. 1 Pages 37 - 44

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To analyze the factors associated with the increase in domestic violence among teachers in the initial period of the pandemic. Methods: Cross-sectional and analytical study, of the websurvey type, carried out with teachers of public basic education in Minas Gerais, Brazil. Data collection took place from August to September 2020, via a digital form. The dependent variable was self-reported domestic violence. Poisson regression was used. Results: 539 teachers participated in the study in situations of domestic violence in the pandemic, of which 6.3% (n = 34) decreased a little and a lot, 58.3% (n = 314) remained the same and 35.4% (n = 191) increased a little and a lot. In the adjusted analysis, a higher prevalence of increased domestic violence was observed among teachers who reported difficulty with teaching work (PR = 1.38; 95%CI 1.01;1.89); with full adherence to social distancing (PR = 1.33; 95%CI 1.01;1.76); worsening of health status (PR = 1.70; 95%CI 1.23;2.36) and in teachers who felt sad or depressed many times or always (PR = 1.57; 95%CI 1.15;2.16). Conclusion: The increase in domestic violence of the pandemic in teachers was associated with work characteristics and mental health conditions.

RESUMO Objetivo: Analisar os fatores associados ao aumento da violência doméstica entre professores no período inicial na pandemia. Métodos: Estudo transversal e analítico, do tipo websurvey , realizado com professores da educação básica pública de Minas Gerais, Brasil. A coleta de dados ocorreu de agosto a setembro de 2020, via formulário digital. A variável dependente foi o autorrelato da violência doméstica. Utilizou-se a Regressão de Poisson. Resultados: Participaram do estudo 539 professores em situação de violência doméstica na pandemia, dos quais 6,3% (n = 34) diminuíram um pouco e muito, 58,3% (n = 314) permaneceram o mesmo e 35,4% (n = 191) aumentaram um pouco e muito. Na análise ajustada, observou-se maior prevalência do aumento da violência doméstica entre os professores que referiram dificuldade com o trabalho docente (RP = 1,38; IC95% 1,01;1,89); com adesão total ao distanciamento social (RP = 1,33; IC95% 1,01;1,76); piora no estado de saúde (RP = 1,70; IC95% 1,23;2,36) e que se sentiram tristes ou deprimidos muitas vezes ou sempre (RP = 1,57; IC95% 1,15;2,16). Conclusão: O aumento da violência doméstica da pandemia em professores foi associado a características laborais e condições de saúde mental.

https://doi.org/10.1590/0047-2085000000402

What’s your diagnosis? A rare cutaneous benign tumor Whats What s diagnosis
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Lopes, Ana G.

; Guimarães, Maria J.

; Cerqueira, Catarina

; Gomes, Joana

; Brito, Celeste

Portuguese Journal of Dermatology and Venereology

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mar 2023, Volume 81 N. 1 Pages 69 - 70

Abstract: En | Text: En | PDF: En

https://doi.org/10.24875/pjdv.22000026

Anal Cancer in Systemic Lupus Erythematosus Patients is a Neglected Condition
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Iamut, Maruska Dib

; Lacerda, Marcela Ignaccthiti

; Araújo Júnior, Mário

; Macedo, Jacyara Maria Brito

; Klumb, Evandro Mendes

Journal of Coloproctology (Rio de Janeiro)

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2023, Volume 43 N. 1 Pages 52 - 55

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Patients with systemic lupus erythematosus have a higher incidence of neoplasms associated with human papillomavirus infections, such as those that affect the vulva, the vagina, and the cervix; however, little is known about the frequency of anal cancer among these patients. Although there are recommendations for screening for this cancer in immunosuppressed individuals, it is possible that this procedure is not strictly followed. We describe the case of a 47-year-old woman with systemic lupus erythematosus who was treated with immunosuppressants and developed advanced anal squamous cell carcinoma after adequate treatment and healing of a high-grade cervical squamous intraepithelial lesion. Five years after the completion of the anal cancer treatment, the patient presented with cystic hepatic lesions that were histopathologically confirmed to be metastatic squamous cell carcinoma. This report aimed to highlight the need for anal cancer screening in patients with lupus, particularly if there was a history of cervical cytopathological alterations.

Resumo Pacientes com lúpus eritematoso sistêmico apresentam maior incidência de neoplasias associadas a infecções por HPV, como aquelas que acometem a vulva, a vagina e o colo do útero, mas pouco se sabe sobre a frequência de câncer anal entre essas pacientes. Embora existam recomendações para o rastreamento desse câncer em indivíduos imunossuprimidos, é possível que esse procedimento não esteja sendo rigorosamente seguido. Descrevemos uma mulher de 47 anos com lúpus eritematoso sistêmico, tratada com imunossupressores, que desenvolveu um carcinoma escamocelular anal avançado após tratamento adequado e cicatrização de lesão intraepitelial escamosa cervical de alto grau. Cinco anos após o término do tratamento do câncer anal, a paciente apresentou lesões císticas hepáticas cujo resultado citopatológico confirmou ser carcinoma escamocelular metastático. O presente relato teve como objetivo chamar atenção para a necessidade do rastreamento do câncer anal em pacientes com lúpus, principalmente se houver história prévia de alterações citopatológicas cervicais.

https://doi.org/10.1055/s-0042-1760220

Prevalence and factors associated with gummy smile in adolescents: a cross-sectional analysis
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Brito, Millena Lopes de

; Silva Junior, Marcelo Lucio Sousa

; Carvalho, Breno Wesley Leal

; Silva, Elen Maria Carvalho da

; Lira, Ana De Lourdes Sá de

Brazilian Journal of Oral Sciences

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2023, Volume 22 elocation e230408

Abstract: En | Text: En | PDF: En

Aim To evaluate the prevalence and factors associated with gummy smiles in adolescents aged between 15 and 18 years attending high school. Methods The cross-sectional and quantitative study was carried out during the Covid-19 pandemic, with 160 adolescents, from two public (A1) and two private (A2) schools chosen by lottery, divided into two groups: G1 (with gummy smile) and G2 (no gummy smile). A clinical examination was carried out on the adolescents, investigating the presence or absence of a gummy smile (GS), by analyzing the variables (interlabial distance at rest, upper incisor exposure at rest, smile arc, measurement from the subnasal to the upper lip philtrum, upper lip length, upper lip thickness, hypermobility and lower/middle third ratio). Means and dispersion were obtained, and the Chi-square association test was applied, to compare the results between A1 and A2 and between G1 and G2. Results The prevalence of GS was 33.8% (=54). It was found that no statistically significant associations were found (p > 0.05), regarding the type of school and gender with the presence of GS in adolescents. There was no statistically significant difference (χ2 = 1.82; p = 0.07) between the groups and the age of adolescents. There was a significant association between the studied variables and GS (p < 0.05). Conclusion The prevalence was high with a predominance of females. There were no statistically significant associations regarding the type of school and gender, but there was a significant association between gummy smile and lip dimensions.

https://doi.org/10.20396/bjos.v22i00.8670408

Translation, Cross-Cultural Adaptation, and Validation of the Hypertension Self-Care Profile (HBP-SCP) for the Brazilian Population
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Baggio, Jussara Almeida de Oliveira

; Ribeiro, Beatriz Brito

; Ribeiro, Jessica Lays Ferreira

; Silva, Fabricio Brito

; Azevedo, Lisiane Fernanda Simeão de

; Mendes, Renata Gonçalves

; Araújo, Aldair Darlan

; Gonçalves, Maria Claudia

; Tavarez, Rudys Rodolfo de Jesus

; Almeida, Denilson Menezes

; Bassi-Dibai, Daniela

International Journal of Cardiovascular Sciences

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2023, Volume 36 elocation e20230075

Abstract: En | Text: En | PDF: En

Abstract Background Self-care in the management of systemic arterial hypertension (SAH) is crucial, and validated instruments can help researchers and health professionals to plan strategies to improve self-care in people with SAH. Objective The main objective of this study was to translate, cross-culturally adapt, and validated the Hypertension Self-Care Profile (HBP-SCP) for Brazilian Portuguese. Methods The translation and cross-cultural adaptation was performed in five phases, and the pre-final version was tested in 30 individuals, native speakers of Portuguese with a diagnosis of hypertension. The final version was administered in 100 individuals. The inclusion criteria were: diagnosis of SAH, characterized by systolic arterial blood pressure ≥ 140 mmHg and/or diastolic arterial blood pressure ≥ 90mmHg, regular use of antihypertensive medications and over 18 years of age. The present study also used two other questionnaires, previously validated for the Brazilian population, to verify the validity of the construct, the Healthy Habits Perception Questionnaire (HHPQ) and the Quality of Life in Hypertension Mini-Questionnaire (MINICHAL-BRASIL). Results During the translation and cross-cultural adaptation phase, there were no disagreements. Adequate reliability — intraclass correlation coefficient (ICC) ≥ 0.89, standard error of measurement (SEM) % ≤ 4.34, minimum detectable change (MDC) % ≤ 12.04 — and internal consistency (Cronbach's alpha ≥ 0.75) were observed. The behavior domain of HBP-SCP obtained significant correlations (p < 0.05) with the self-efficacy domain and HHPQ; the motivation domain with the self-efficacy domain; and the self-efficacy domain with the somatic manifestation domain of MINICHAL-BRASIL. No ceiling and floor effects were observed. Conclusions The Brazilian Portuguese version of the HBP-SCP has adequate psychometric properties, according to the best scientific recommendations.

https://doi.org/10.36660/ijcs.20230075

Otoneurological assessment and quality of life of individuals with complaints of dizziness and temporomandibular disorders: a case-control study
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Honorato, Mônica Claudino Medeiros

; Tavares, Luiz Felipe

; Bedaque, Henrique de Paula

; Mantello, Erika Barioni

; Almeida, Erika Oliveira de

; Ribeiro, Karyna Myrelly Oliveira Bezerra de Figueiredo

; Ferreira, Lidiane Maria de Brito Macedo

Brazilian Journal of Otorhinolaryngology

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dec 2022, Volume 88 Pages 185 - 191

Abstract: En | Text: En | PDF: En

Abstract Objectives: To evaluate the impact of temporomandibular disorders on the quality of life of patients with dizziness. Methods: An observational, case-control study evaluated 60 individuals with dizziness (20 cases and 40 controls), who were matched for gender and age. The individuals underwent to anamnesis, overall physical and otoneurological examination, tonal and vocal audiometry and impedanciometry, video head impulse test and the dizziness handicap inventory questionnaire. Results: The otoscopy was normal for all patients. There was an association between the presence of temporomandibular disorders and aural fullness (p<0.01) and otalgia (p<0.01). Audiometry was normal in 90% of the patients in the case group, with a significant association between temporomandibular disorders and normal audiometry (p<0.01). The video head impulse test findings were normal in 66% of the patients in the case group and 45% of the control group, and there was no association between having temporomandibular disorders and vestibular alterations at the video head impulse test (p = 0.12). There were significant differences in total dizziness handicap inventory and in the functional and emotional domains (p<0.01), with higher scores in the control group. Conclusion: Aural fullness and otalgia symptoms are associated with temporomandibular disorders in patients with dizziness, and there is an association between normal complementary audiological tests and temporomandibular disorders. Vestibular alterations are not associated with temporomandibular disorders. However, patients with dizziness and without temporomandibular disorders showed greater quality of life impairment. Level of evidence: 3. Original case-control study.

https://doi.org/10.1016/j.bjorl.2022.04.005

10.

Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
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Meneses, Richard Rarison Cavalcante

; Damasceno, Nágila Raquel Teixeira

; Cartolano, Flávia De Conti

; Verde, Sara Maria Moreira Lima

; Lira, Letícia Gomes

; Dantas, Mariana Brito

; Viana, Glautemberg de Almeida

; Silva, Mateus Edson da

; Sousa, Ederson Laurindo Holanda de

; Meneses, Gdayllon Cavalcante

; Ferreira, Jamile Magalhães

; Sampaio, Tiago Lima

; Queiroz, Maria Goretti Rodrigues de

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e20488

Abstract: En | Text: En | PDF: En

Abstract Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters.

https://doi.org/10.1590/s2175-97902022e20488

11.

Guía basada en la evidencia. Diagnóstico y manejo del síndrome de Guillain-Barré en diez pasos
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Leonhard, Sonja E.

; Mandarakas, Melissa R.

; De Assis Aquino Gondim, Francisco

; Bateman, Kathleen

; Brito Ferreira, Maria L.

; Cornblath, David R.

; Van Doorn, Pieter A.

; Dourado, Mario E.

; Hughes, Richard A.C.

; Islam, Badrul

; Kusunoki, Susumu

; Pardo, Carlos A.

; Reisin, Ricardo

; Sejvar, James J.

; Shahrizaila, Nortina

; Soares, Cristiane

; Umapathi, Thirugnanam

; Wang, Yuzhong

; Yiu, Eppie M.

; Willison, Hugh J.

; Jacobs, Bart C.

Medicina (Buenos Aires)

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oct 2021, Volume 81 N. 5 Pages 817 - 836

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Guillain-Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and in 2015 in Latin America. Diagnosis and management of GBS can be complicated as its clinical presentation and disease course are heterogeneous, and no international clinical guidelines are currently available. To support clinicians, especially in the context of an outbreak, we have developed a globally applicable guideline for the diagnosis and management of GBS. The guideline is based on current literature and expert consensus, and has a ten-step structure to facilitate its use in clinical practice. We first provide an introduction to the diag nostic criteria, clinical variants and differential diagnoses of GBS. The ten steps then cover early recognition and diagnosis of GBS, admission to the intensive care unit, treatment indication and selection, monitoring and treatment of disease progression, prediction of clinical course and outcome, and management of complications and sequelae.

Resumen El síndrome de Guillain-Barré (SGB) es una enfermedad inmunológica del nervio periférico y las raíces nerviosas, poco frecuente, potencialmente mortal y que suele desencadenarse por infecciones. La incidencia del SGB puede aumentar durante el brote de enfermedades infecciosas, tal como se observó en las epidemias del virus Zika en la Polinesia Francesa en 2013 y en América Latina en 2015. El diagnóstico y el manejo clínico del SGB pueden ser complicados ya que su presentación y el curso de la enfermedad son heterogéneos, y actualmente no se cuenta con guías clínicas internacionales. Para respaldar a los médicos, especialmente en el contexto de un brote de una enfermedad infecciosa, hemos desarrollado una guía clínica aplicable en todo el mundo para el diagnóstico y el tratamiento del SGB. La guía se basa en literatura actualizada y el consenso de expertos, y tiene una estructura de diez pasos para facilitar su uso en la práctica clínica. Inicialmente, brindamos una introducción a los criterios de diagnóstico, variantes clínicas y diagnósticos diferenciales del SGB. Los diez pasos luego abordan el reconocimiento y el diagnóstico temprano del SGB, la admisión a la unidad de cuidados intensivos, indicación y selección de tratamiento, seguimiento y tratamiento de la progresión de la enfermedad, predicción del curso clínico, resultados y tratamiento de complicaciones y secuelas.

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12.

Modelos de agricultura sustentável: biodinâmica e sistema silvipastoril
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Mascarenhas¹, Nágela M. H.

; Furtado¹, Dermeval A.

; Cavalcante¹, Cácio R.

; Costa², Antonio N. L. da

; Souza², Maria A. de

; Gonçalves¹, Mailson G.

; Oliveira¹, Airton G. de

; Brito¹, Alicia N. dos S. L. de

; Silva¹, Luís P. F. R. da

; Nogueira¹, Lídia P. da S.

; Dornelas¹, Karoline C.

; Rodrigues¹, Raimundo C. M.

; Neto¹, Moises S. de Medeiros

; Paiva¹, Francisco J. da S.

; Silva¹, Semirames do N.

Revista de Ciências Agrárias

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sep 2020, Volume 43 N. 3 Pages 228 - 245

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo desta revisão foi comparar dois modelos de agricultura sustentáveis, demostrando as vantagens e desvantagens de ambos, correlacionando-os entre si. As diversas práticas agrícolas contemporâneas compreendem modelos alternativos de agricultura, como permacultura, agricultura biológica, orgânica, biodinâmica, que são consideradas sustentáveis, e modelos intensivos de produção, que apresentam vários pontos negativos, contrastando com os modelos alternativos. A busca por uma agricultura menos agressiva ao meio ambiente, que permaneça produtiva em longo prazo, tem sido uma preocupação constante de pesquisadores e produtores. Os modelos de agricultura assemelham-se entre si, o que os difere são apenas algumas práticas que não são permitidas em todos, e suas bases de fundamentação. Nesta revisão dois modelos foram mais abordados de forma simplificada, para a percepção dos seus conceitos e de suas bases fundamentais, mostrando o que os diferencia, e que mesmo assim os leva para um mesmo objetivo, criar um ecossistema independente de recursos externos.

ABSTRACT The objective of this review was to compare two models of sustainable agriculture, demonstrating their advantages and disadvantages and correlating them with each other. The diverse contemporary agricultural practices comprise from alternative models of agriculture, such as permaculture, organic farming, organic, biodynamic, that are considered sustainable, and intensive production models, that present several negative points, contrasting with alternative models. The search for a less aggressive agriculture to the environment, what stay productive in the long run, it has been a constant concern of researchers and producers. Agricultural models are similar to each other, what differs are some practices that do not are allowed in all, and its foundation bases. In this review, two models were more approached in a simplified way, to the perception of their concepts and fundamental bases, showing what differentiates them, and that still leads to the same goal, creating an ecosystem independent of external resources.

https://doi.org/10.19084/rca.20853 46 downloads

13.

Metabolomics-Based Discovery of Biomarkers with Cytotoxic Potential in Extracts of Myracrodruon urundeuva
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Castro, Caio B.

; Luz, Licia R.

; Guedes, Jhonyson A. C.

; Porto, Diogo D.

; Silva, Maria Francilene S.

; Silva, Gisele S.

; Ribeiro, Paulo R. V.

; Canuto, Kirley M.

; Brito, Edy S.

; Zampieri, Dávila S.

; Pessoa, Claúdia Ó.

; Zocolo, Guilherme J.

Journal of the Brazilian Chemical Society

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apr 2020, Volume 31 N. 4 Pages 775 - 787

Abstract: En | Text: En | PDF: En

Myracrodruon urundeuva (“aroeira-do-sertão”) is a species threatened with extinction due to anthropogenic exploitation. Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids. Dereplication methodology was performed to tentatively identify 50 compounds analyzed by ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry operating in MSE mode (UPLC-QTOF-MSE). The extracts exhibited anti-tumor effect in cancer cells HCT-116 (colorectal), SF-295 (glioblastoma), HL-60 (leukemia), and RAJI (leukemia). Also, these results correlate with the principal component analysis (PCA) data that identified three distinct groups indicating, efficiently, metabolic differences between organs of M. urundeuva. Through discriminatory analysis of the orthogonal partial least squares (OPLS-DA), the variable of importance in the projection (VIP) and S-Plot, we were able to determine 30 potential biomarkers. The fingerprint of hydroethanolic extracts was correlated with the cytotoxicity assay and demonstrated a significant difference in the composition of plant extract.

https://doi.org/10.21577/0103-5053.20190242 361 downloads

14.

GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic Activities of Non-Polar Leaf Extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
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Guedes, Jhonyson A. C.

; Alves Filho, Elenilson G.

; Silva, Maria F. S.

; Rodrigues, Tigressa H. S.

; Ramires, Christiane M. C.

; Lima, Maria A. C.

; Silva, Gisele S.

; Pessoa, Cláudia Ó.

; Canuto, Kirley M.

; Brito, Edy S.

; Alves, Ricardo E.

; Nascimento, Ronaldo F.

; Zocolo, Guilherme J.

Journal of the Brazilian Chemical Society

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feb 2020, Volume 31 N. 2 Pages 331 - 340

Abstract: En | Text: En | PDF: En

Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds.

https://doi.org/10.21577/0103-5053.20190185 596 downloads

15.

Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy of Neurology and Brazilian Committee on Treatment and Research in Multiple Sclerosis
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Marques, Vanessa Daccach

; Passos, Giordani Rodrigues dos

; Mendes, Maria Fernanda

; Callegaro, Dagoberto

; Lana-Peixoto, Marco Aurélio

; Comini-Frota, Elizabeth Regina

; Vasconcelos, Cláudia Cristina Ferreira

; Sato, Douglas Kazutoshi

; Ferreira, Maria Lúcia Brito

; Parolin, Mônica Koncke Fiuza

; Damasceno, Alfredo

; Grzesiuk, Anderson Kuntz

; Muniz, André

; Matta, André Palma da Cunha

; Oliveira, Bianca Etelvina Santos de

; Tauil, Carlos Bernardo

; Maciel, Damacio Ramón Kaimen

; Diniz, Denise Sisteroli

; Corrêa, Eber Castro

; Coronetti, Fernando

; Jorge, Frederico M. H.

; Sato, Henry Koiti

; Gonçalves, Marcus Vinícius Magno

; Sousa, Nise Alessandra de C.

; Nascimento, Osvaldo J. M.

; Gama, Paulo Diniz da

; Domingues, Renan

; Simm, Renata Faria

; Thomaz, Rodrigo Barbosa

; Morales, Rogério de Rizo

; Dias, Ronaldo Maciel

; Apóstolos-Pereira, Samira dos

; Machado, Suzana Costa Nunes

; Junqueira, Thiago de Faria

; Becker, Jefferson

Arquivos de Neuro-Psiquiatria

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aug 2018, Volume 76 N. 8 Pages 539 - 554

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O crescent arsenal terapêutico na esclerose múltipla (EM) tem permitido tratamentos mais efetivos e personalizados, mas a escolha e o manejo das terapias modificadoras da doença (TMDs) tem se tornado cada vez mais complexos. Neste contexto, especialistas do Comitê Brasileiro de Tratamento e Pesquisa em Esclerose Múltipla e do Departamento Científico de Neuroimunologia da Academia Brasileira de Neurologia reuniram-se para estabelecer este Consenso Brasileiro para o Tratamento da EM, baseados no entendimento de que neurologistas devem ter a possibilidade de prescrever TMDs para EM de acordo com o que é melhor para cada paciente, com base em evidências e práticas atualizadas. Por meio deste documento, propomos recomendações práticas para o tratamento da EM, com foco principal na escolha e no manejo das TMDs, e revisamos os argumentos que embasam as estratégias de tratamento na EM.

ABSTRACT The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Research in Multiple Sclerosis and the Neuroimmunology Scientific Department of the Brazilian Academy of Neurology have convened to establish this Brazilian Consensus for the Treatment of MS, based on their understanding that neurologists should be able to prescribe MS DMTs according to what is better for each patient, based on up-to-date evidence and practice. We herein propose practical recommendations for the treatment of MS, with the main focus on the choice and management of DMTs, as well as present a review of the scientific rationale supporting therapeutic strategies in MS.

https://doi.org/10.1590/0004-282x20180078 8891 downloads

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