Non-cancerous prognostic factors of hepatocellular carcinoma after liver transplantation

Fatores prognósticos não oncológicos no carcinoma hepatocelular tratado com transplante hepático

Thales Paulo Batista Luiz Eduardo Correia Miranda Bernardo David Sabat Paulo Sérgio Vieira de Melo Olival Cirilo Lucena da Fonseca Neto Américo Gusmão Amorim Cláudio Moura Lacerda About the authors

PURPOSE: To explore non-cancerous factors that may be related with medium-term survival (24 months) after liver transplantation (LT) in this data from northeast Brazil. METHODS: A cross-sectional study was carried out in patients who underwent deceased-donor orthotopic LT because hepatocellular carcinoma (HCC) at the University of Pernambuco, Brazil. Non-cancerous factors (i.e.: donor-, receptor-, surgery- and center-related variables) were explored as prognostic factors of medium-term survival using univariate and multivariate approachs. RESULTS: Sixty-one patients were included for analysis. Their three, six, 12 and 24-month overall cumulative survivals were 88.5%, 80.3%, 73.8% and 65.6%, respectively. Our univariate analysis identified red blood cell transfusion (Exp[b]=1.26; p<0.01) and hepato-venous reconstruction technique (84.6% vs. 51.4%, p<0.01; respectively for piggyback and conventional approaches) as significantly related to post-LT survival. The multivariate analysis confirmed the hepato-venous reconstruction technique was an independent prognostic factor. CONCLUSION: The piggyback technique was related to improved medium-term survival of hepatocellular carcinoma patients after liver transplantation in this northeast Brazilian sample.

Organ Transplantation; Liver Neoplasms; Carcinoma, Hepatocellular; Survival Analysis; Prognosis

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