PURPOSE: The aim of this experimental study is to evaluate the outcomes of having Nissen fundoplication done on rats through the histological analysis of the distal esophagus and manometric study of the lower esophageal sphincter (LES), as well as the evaluation of weight variation of the rats subjected to this procedure, in distinct days after surgery. METHODS: Have been used 70 male Wistar rats, at the ages of 100 to 130 days , weighing from 250 to 300 grams and divided into 2 groups. The experiment group was composed of 60 rats, subdivided into 6 subgroups according to the time of post-operatory manometric measurement: 02, 07, 14, 21, 28 and 40 days, and subjected to fundoplication with posterior manometric analysis of the LES and histological analysis of the distal esophagus. The control group was composed of the ten left animals, which were subjected only to laparotomy with manipulation of the gastric-esophageal junction, and the same analysis has been performed. RESULTS: Histological analysis evidenced statistically significant edema (p=0,0000) accompanied of weight loss in the subgroups 02 and 07 days. Significant statistic in the manometric study of all groups compared to the control group has been observed (p=0,0018). The edema and weight correlation was linear significant and inversely proportional (t= 2,577 < t c= +2,132). Sgnificant linear and directly proportional correlation between edema and manometric has been established (t= +6,085 > t c= +2,132). CONCLUSION: After Nissen procedure in rats, the pressure in the LES does not return to the levels of control group until the 40º post-operatory day. The edema correlated with weight loss and pressure rise in the LES can be the main variable related to the possible dysphagia.
Fundoplication; Dysphagia; Edema; Manometry
