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CLINICAL INVESTIGATION • Acta Cir. Bras. 35 (9) • 2020 • https://doi.org/10.1590/s0102-865020200090000007   copy

Antibiotic prophylaxis in breast cancer surgery. A randomized controlled trial1 1 Research performed at Professional Master’s Program in Applied Health Sciences, Universidade do Vale do Sapucaí (UNIVÁS), Pouso Alegre-MG, Brazil. Part of Master degree thesis. Tutor: Daniela Francescato Veiga.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Purpose

To assess the effect of antibiotic prophylaxis on surgical site infection (SSI) rates in women undergoing breast cancer surgery in two tertiary hospitals in Brazil.

Methods

This was a randomized, double-blind, placebo-controlled, parallel-group clinical trial. A total of 124 women without independent risk factors for SSI were randomly assigned to receive either cefazolin (antibiotic group, n = 62) or placebo (control group, n = 62) as preoperative prophylaxis. After surgery, all surgical wounds were examined once a week, for four weeks, according to the Centers for Disease Control and Prevention definitions and classifications for SSI.

Results

Baseline characteristics were homogeneous between the two groups. Only one patient in the antibiotic group developed SSI, which was classified as superficial incisional. The overall SSI rate was low, with no significant difference between groups.

Conclusion

Antibiotic prophylaxis had no significant effect on reducing SSI rates in women without independent risk factors for SSI undergoing breast cancer surgery.

Antibiotic Prophylaxis; Breast Neoplasms; Postoperative Care; Surgical Wound Infection

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia https://actacirbras.com.br/ - São Paulo - SP - Brazil
E-mail: actacirbras@gmail.com
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