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Prevalência de Streptococcus suis sorotipo 2: discussão da literatura brasileira

Prevalence of Streptococcus suis serotype 2: discussion of the Brazilian literature


Streptococcus suis é mundialmente considerado um dos patógenos de maior impacto sanitário e econômico na indústria suinícola. Dentre os sorotipos descritos como zoonóticos, o sorotipo 2 é o mais frequentemente isolado de animais e humanos doentes na maioria dos países. O estudo da epidemiologia das infecções por S. suis no Brasil é importante para a implantação de medidas efetivas de controle. O objetivo do presente trabalho foi realizar uma revisão crítica da literatura brasileira, com suporte da literatura mundial, abordando o diagnóstico do agente e sua prevalência em animais clinicamente doentes e portadores sadios, com destaque para a prevalência do sorotipo 2 no país.

Streptococcus suis sorotipo 2; prevalência; revisão de literatura

Streptococcus suis is considered worldwide as one of the pathogens of biggest health and economic impact in the swine industry. Among the serotypes described as zoonotic, serotype 2 is the most frequently isolated from diseased animals and humans in most countries. The study of the epidemiology of S. suis infections in Brazil is important and may help in the development of effective control measures. The aim of this study was to conduct a critical review of Brazilian literature, with support of the world literature, addressing the diagnosis of the agent and its prevalence in clinically ill animals and healthy carriers, especially regarding to the prevalence of the serotype 2 in the country.

Streptococcus suis serotype 2; prevalence; literature review

  • AARESTRUP, F.M.; JORSAL, S.E.; JENSEN, N.E. Serological characterization and antimicrobial susceptibility of Streptococcus suis isolates from diagnostic samples in Denmark during 1995 and 1996. Veterinary Microbiology, v.60, n.1, p.59-66, 1998.
  • AMASS, S.F.; CLARK, L.K.; KNOX, K.E.; WU, C.C.; HILL, M.A. Streptococcus suis colonization of piglets during parturition. Swine Health and Production, v.4, n.6, p.269-272, 1996.
  • AMASS, S.F.; KREISLE, R.A.; CLARK, L.K.; WU, C.C. A pilot study of the prevalence of Streptococcus suis in pigs and personnel at five indiana swine operations. Journal of Agromedicine, v.5, n.1, p.17-24, 1998.
  • ARENDS, J.P.; ZANEN, H.C. Meningitis caused by Streptococcus suis in humans. Review of Infectious Diseases, v.10, n.1, p.131-137, 1988.
  • BAELE, M.; CHIERS, K.; DEVRIESE, L.A.; SMITH, H.E.; WISSELINK, H.J.; VANEECHOUTTE, M.; HAESEBROUCK, F. The gram-positive tonsillar and nasal flora of piglets before and after weaning. Journal of Applied Microbiology, v.91, n.6, p.997-1003, 2001.
  • BOETNER, A.G.; BINDER, M.; BILLE-HANSEN, V. Streptococcus suis infection in Danish pigs and experimental infection with Streptococcus suis serotype 7. Acta Pathologica, Microbiologica, et Immunologica Scandinavica. Section B, Microbiology, v.95, n.4, p.233-239, 1987.
  • BOSCO, S.M.G.; PEZERICO, S.B.; CABRAL, K.G.; SILVA, A.V.; LANGONI, H. Streptococcus suis tipo II em suínos e perfil de susceptibilidade a antimicrobianos. Arquivos do Instituto Biológico, São Paulo, v.67, n.2, p.157-160, 2000.
  • BRISEBOIS, L.M.; CHARLEBOIS, R.; HIGGINS, R.; NADEAU, M. Prevalence of Streptococcus suis in four to eight week old clinically healthy piglets. Canadian Journal of Veterinary Research, v.54, n.1, p.174-177, 1990.
  • BROUSSEAU R.; HILL, J.E.; PRÉFONTAINE, G.; GOH, SH; HAREL, J.; HEMMINGSEN, S.M. Streptococcus suis serotypes characterized by analysis of chaperonin 60 gene sequences. Applied and Environmental Microbiology, v.67, n.10, p.4828-4833, 2001.
  • CHATELLIER, S.; HAREL, J.; ZHANG, Y.; GOTTSCHALK, M.; HIGGINS, R.; DEVRIESE, L.A.; BROUSSEAU, R. Phylogenetic diversity of Streptococcus suis strains of various serotypes as revealed by 16s rRNA gene sequence comparison. International Journal of Systematic Bacteriology, v.48, n.2, p.581-589, 1998.
  • CLOUTIER G.; D'ALLAIRE, S.; MARTINEZ, G.; SURPRENANT, C.; LACOUTURE, S.; GOTTSCHALK, M. Epidemiology of Streptococcus suis serotype 5 infection in a pig herd with and without clinical disease. Veterinary Microbiology, v.97, p.135-151, 2003.
  • COSTA, A.T.R.; LOBATO, F.C.F.; ABREU, V.L.V.; ASSIS, R.A.; REIS, R.; UZAL, F.A. Serotyping and evaluation of the virulence in mice of Streptococcus suis strains isolated from diseased pigs. Revista do Instituto de Medicina Tropical de São Paulo, v.47, n.2, p.113-115, 2005.
  • DEL'ARCO, A.E.; SANTOS, J.L.; BEVILACQUA, P.D.; FARIA, J.E.; GUIMARÃES, W.V. Swine infection by Streptococcus suis: a retrospective study. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v.60, n.4, p.878-883, 2008.
  • ELLIOTT, S.D.; TAI, J.Y. The type-specific polysaccharides of Streptococcus suis. The Journal of Experimental Medicine, v.148, n.6, p.1699-1704, 1978.
  • FARIA, A.C.S.; SILVA, M.C.; OLIVEIRA FILHO, J.X.; OLIVEIRA, J.T.; PAULA, D.A.J.; CHITARRA, C.S.; NAKAZATO, L.; DUTRA, V. Prevalência de Streptococcus suis tipo 2 por meio da técnica de reação em cadeia da polimerase em suínos abatidos no Estado do Mato Grosso. Ciência Rural, v.40, n.1, p.130-134, 2010.
  • FITTIPALDI, N.; FULLER, T.E.; TEEL, J.F.; WILSON, T.L.; WOLFRAM, T.J.; LOWERY, D.E.; GOTTSCHALK, M. Serotype distribution and production of muramidase-released protein, extracellular factor and suilysin by field strains of Streptococcus suis isolated in the United States. Veterinary Microbiology, v.139, p.310-317, 2009.
  • FLORES, J.L.M.; HIGGINS, R.; D'ALLAIRE, S.; CHARETTE, R.; BOUDREAU, M.; GOTTSCHALK, M. Distribution of the different capsular types of Streptococcus suis in nineteen swine nurseries. Canadian Veterinary Journal, v.34, n.3, p.170-171, 1993.
  • GALINA, L.; COLLINS, J.E.; PIJOAN, C. Porcine Streptococcus suis in Minnesota. Journal of Veterinary Diagnostic Investigation, v.4, n.2, p.195-196, 1992.
  • GOTTSCHALK, M.; HIGGINS, R.; JACQUES, M.; MITTAL, K.R.; HENRICHSEN, J. Description of 14 new capsular types of Streptococcus suis. Journal of Clinical Microbiology, v.27, n.12, p.2633-2636, 1989.
  • GOTTSCHALK, M.; HIGGINS, R.; JACQUES, M.; BEAUDOIN, M.; HENRICHSEN, J. Isolation and characterization of Streptococcus suis capsular types 9-22. Journal of Veterinary Diagnostic Investigation, v.3, n.1, p.60-65, 1991a.
  • GOTTSCHALK, M.; HIGGINS, R.; JACQUES, M; BEAUDOIN, M.; HENRICHSEN, J. Characterization of six new capsular types (23 through 28) of Streptococcus suis. Journal of Clinical Microbiology, v.29, n.11, p.2590-2594, 1991b.
  • GOTTSCHALK, M.; HIGGINS, R.; BOUDREAU, M. Use of polyvalent coagglutination reagents for serotyping of Streptococcus suis. Journal of Clinical Microbiology, v.31, n.8, p.2192-2194, 1993.
  • GOTTSCHALK, M.; LACOUTURE, S.; ODIERNO, L. Immunomagnetic isolation of Streptococcus suis serotypes 2 and 1/2 from swine tonsils. Journal of Clinical Microbiology, v.37, n.9, p.2877-2881, 1999.
  • GOTTSCHALK, M.; SEGURA, M.; XU, J. Streptococcus suis infections in humans: the Chinese experience and the situation in North America. Animal Health Research Reviews, v.8, n.1, p.29-45, 2007.
  • HALEIS, A.; ALFA, M.; GOTTSCHALK, M.; BERNARD, K.; RONALD, A.; MANICKAM, K. Meningitis caused by Streptococcus suis serotype 14, North America. Emerging Infectious Diseases, v.15, n.2, p.350-352, 2009.
  • HAN, D.U.; CHOI, C.; HAM, H.J.; JUNG, J.H.; CHO, W.S.; KIM, J.; HIGGINS, R.; CHAE, C. Prevalence, capsular type and antimicrobial susceptibility of Streptococcus suis isolated from slaughter pigs in Korea. Canadian Journal of Veterinary Research, v.65, n.3, p.151-155, 2001.
  • HIGGINS, R.; GOTTSCHALK, M.; BEAUDOIN, M.; RAWLUK, S.A. Distribution of Streptococcus suis capsular types in Quebec and western Canada. Canadian Veterinary Journal, v.33, n.1, p.27-30, 1992.
  • HIGGINS, R.; GOTTSCHALK, M.; BOUDREAU, M.; LEBRUN, A.; HENRICHSEN, J. Description of six new capsular types (29-34) of Streptococcus suis. Journal of Veterinary Diagnostic Investigation, v.7, n.3, p.405-406, 1995.
  • HIGGINS, R.; GOTTSCHALK, M. Quebec. Distribution of Streptococcus suis capsular types in Canada in 1992. Canadian Veterinary Journal, v.34, n.7, p.442, 1993.
  • HIGGINS, R.; GOTTSCHALK, M. Distribution of Streptococcus suis capsular types in 2000. Canadian Veterinary Journal, v.42, n.3, p.223, 2001.
  • HIGGINS, R.; GOTTSCHALK, M. Streptococcal diseases. In: STRAW, B.E.; D'ALLAIRE, S.; MENGELING, W.L.; TAYLOR, D.J. Diseases of swine. Ames, IA: Iowa State University, 2005. p.769-83.
  • JACOBS, A.A.; VAN DEN BERG, A.J.; BAARS, J.C.; NIELSEN, B.; JOHANNSEN, L.W. Production of suilysin, the thiol-activated haemolysin of Streptococcus suis, by field isolates from diseased pigs. The Veterinary Record, v.137, n.12, p.295-296, 1995.
  • JU, Y.; HAO, H.J.; XIONG, G.H.; GENG, H.R.; ZHENG, Y.L.; WANG, J.; CAO, Y.; YANG, Y.H.; CAI, X.H.; JIANG, Y.Q. Development of colloidal gold-based immunochromatographic assay for rapid detection of Streptococcus suis serotype 2. Veterinary Immunology and Immunopathology, v.133, p.207-211, 2010.
  • KATAOKA, Y.; SUGIMOTO, C.; NAKAZAWA, M.; KASHIWAZAKI, M. Detection of Streptococcus suis type 2 in tonsils of slaughtered pigs using improved selective and differential media. Veterinary Microbiology, v.28, n.4, p.335-342, 1991.
  • KATAOKA, Y.; SUGIMOTO, C.; NAKAZAWA, M.; MOROZUMI, T.; KASHIWAZAKI, M. The epidemiological studies of Streptococcus suis infections in Japan from 1987 to 1991. Journal of Veterinary Medical Science, v.55, n.4, p.623-626, 1993.
  • KATSUMI, M.; KATAOKA, Y.; TAKAHASHI, T.; KIKUCHI, N.; HIRAMUNE, T. Bacterial isolation from slaughtered pigs associated with endocarditis, especially the isolation of Streptococcus suis. Journal of Veterinary Medical Science, v.59, n.1, p.75-78, 1997.
  • KERDSIN A.; DEJSIRILERT, S.; SAWANPANYALERT, P.; BOONNARK, A.; NOITHACHANG, W.; SRIYANKUM, D.; SIMKUM, S.; CHOKNGAM, S.; GOTTSCHALK, M.; AKEDA, Y.; OISHI, K. Sepsis and spontaneous bacterial peritonitis in Thailand. Lancet, v.378, n.9794, p.960, 2011.
  • LARA, A.C.; MORES, M.A.Z.; SONCINI, R.A.; ALBERTON, G.C. Prevalência de Streptococcus suis sorotipo 2 em tonsilas de suínos sadios em idade de abate no estado de Santa Catarina. Archives of Veterinary Science, v.12, n.2, p.31-34, 2007.
  • LUN, Z.R.; WANG, Q.P.; CHEN, X.G.; LI, A.X.; ZHU, X.Q. Streptococcus suis: an emerging zoonotic pathogen. The Lancet Infectious Diseases, v.7, n.3, p.201-209, 2007.
  • LUQUE, L.; TARRADAS, C.; ARENAS, A.; MALDONADO, A.; ASTORGA, R.; PEREA, A. Streptococcus suis serotypes associated with different disease conditions in pigs. The Veterinary Record, v.142, n.26, p.726-727, 1998.
  • MACLENNAM, M.; FOSTER, G.; DICK, K.; SMITH, W.J.; NIELSEN, B. Streptococcus suis serotypes 7, 8 and 14 from diseased pigs in Scotland. The Veterinary Record, v.139, n.17, p.423-424, 1996.
  • MADUREIRA JR, S.; SONCINI, R.A. Meningite estreptocócica, experiência da agroindústria. In: SIMPÓSIO SOBRE MENINGITE ESTREPTOCÓCICA E PLEUROPNEUMONIA SUÍNA, 1999, Lages. Resumos. Lages: 1999. p.24-27.
  • MAROIS, C.; BOUGEARD, S.; GOTTSCHALK, M.; KOBISCH, M. Multiplex PCR assay for detection of Streptococcus suis species and serotypes 2 and 1/2 in tonsils of live and dead pigs. Journal of Clinical Microbiology, v.42, n.7, p.3169-3175, 2004.
  • MAROIS, C.; DEVENDEC, L.L.; GOTTSCHALK, M.; KOBISCH, M. Detection and molecular typing of Streptococcus suis in tonsils from live pigs in France. Canadian Journal of Veterinary Research, v.71, n.1, p.14-22, 2007.
  • MESSIER, S.; LACOUTURE, S.; GOTTSCHALK, M. Distribution of Streptococcus suis capsular types from 2001 to 2007. Canadian Veterinary Journal, v.49, n.5, p.461-462, 2008.
  • OKWUMABUA, O.; O'CONNOR, M.; SHULL, E. A polymerase chain reaction (PCR) assay for Streptococcus suis based on the gene encoding the glutamate dehydrogenase. FEMS Microbiology Letters, v.218, n.1, p.79-84, 2003.
  • OLIVEIRA, J.T. Prevalência e perfil de sensibilidade antimicrobiana de Streptococcus suis sorotipo 2 em suínos abatidos em frigoríficos de Mato Grosso. 2008. Dissertação (Mestrado em Ciências Veterinárias) - Universidade Federal de Mato Grosso, Cuiabá, 2008.
  • PAGNANI, K.J.R.; CASTRO, A.F.P.; GOTTSCHALK, M.; SILVEIRA, W.D.; NAKAZATO, G. Sorotipagem de amostras de Streptococcus suis isoladas de suínos em granjas dos estados de São Paulo, Minas Gerais e Paraná. Pesquisa Veterinária Brasileira, v.22, n.1, p.1-5, 2002.
  • PERCH, B.; PEDERSEN, K.B.; HENRICHSEN, J. Serology of capsulated streptococci pathogenic for pigs: six new serotypes of Streptococcus suis. Journal of Clinical Microbiology, v.17, n.6, p.993-996, 1983.
  • ROBERTSON, I.D. An indirect fluorescent antibody technique for the detection of Streptococcus suis type 2. New Zealand Journal of Medical Laboratory Technology, v.39, p.171-172, 1985.
  • SALA, V.; ANTONINI, M.; VISCHI, O. Distribution of capsular types and hemolysin production of Streptococcus suis isolates in northern Italy. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 14., 1996, Bologna, Point. Proceedings. Bologna: 1996. v.14, p.307.
  • SANTOS, J.L. Distribuição de sorotipos de Streptococcus suis em suínos clinicamente doentes no Brasil. In: CONGRESSO BRASILEIRO DE VETERINÁRIOS ESPECIALISTAS EM SUÍNOS (ABRAVES), 9., 1999, Belo Horizonte. Resumos. Belo Horizonte: 1999. p. 239-240.
  • SERHIR, B.; HIGGINS, R.; FOIRY, B.; JACQUES, M. Detection of immunoglobulin-G-binding proteins in Streptococcus suis. Journal of General Microbiology, v.139, n.12, p.2953-2958, 1993.
  • SEPÚLVEDA, E.M.C.; ALTMAN, E.; KOBISCH, M.; D'ALLAIRE, S.; GOTTSCHALK, M. Detection of antibodies against Streptococcus suis capsular serotype 2 using a purified polysaccharide antigen-based indirect ELISA. Veterinary Microbiology, v.52, n.1-2, p.113-125, 1996.
  • SIHVONEN, L.; KURL, D.N.; HENRICHSEN, J. Streptococcus suis isolated from pigs in Finland. Acta Veterinaria Scandinavica, v.29, n.1, p.9-13, 1988.
  • SMITH, H.E.; VAN BRUIJNSVOORT, L.; BUIJS, H.; WISSELINK, H.J.; SMITS, M.A. Rapid PCR test for Streptococcus suis serotype 7. FEMS Microbiology Letters, v.178, n.2, p.265-270, 1999a.
  • SMITH, H.E.; VEENBERGEN, V.; VAN DER VELDE, J.; DAMMAN, M.; WISSELINK, H.J.; SMITS, M.A. The cps genes of Streptococcus suis serotypes 1, 2, and 9: development of rapid serotype-specific PCR assays. Journal of Clinical Microbiology, v.37, n.10, p.3146-3152, 1999b.
  • SOBESTIANSKY, J.; BARCELLOS, D.E.S.; MORES, N.; OLIVEIRA, S.J.; CARVALHO, L.F.O.; MORENO, A.M.; ROEHE, P.M. Clínica e patologia suína. Goiânia, 2001. 464p.
  • STAATS, J.J.; FEDER, I.; OKWUMABUA, O.; CHENGAPPA, M.M. Streptococcus suis: past and present. Veterinary Research Communications, v.21, n.6, p.381-407, 1997.
  • TOUIL, F.; HIGGINS, R.; NADEAU, M. Isolation of Streptococcus suis from diseased pigs in Canada. Veterinary Microbiology, v.17, n.2, p.171-177, 1988.
  • VELA, A.I.; GOYACHE, J.; TARRADAS, C.; LUQUE, I.; MATEOS, A.; MORENO, M.A.; BORGE, C.; PEREA, J.A.; DOMÍNGUEZ, L.; FERNÁNDEZ-GARAYZÁBAL, J.F. Analysis of genetic diversity of Streptococcus suis clinical isolates from pigs in Spain by pulsed-field gel electrophoresis. Journal of Clinical Microbiology, v.41, n.6, p.2498-2502, 2003.
  • VILAICHONE, R.K.; MAHACHAI, V.; NUNTHAPISUD, P. Streptococcus suis peritonitis: case report. Journal of the Medical Association of Thailand, v.83, n.10, p.1274-1277, 2000.
  • WEI, Z.; LI, R.; ZHANG, A.; HE, H.; HUA, Y.; XIA, J.; CAI, X.; CHEN, H.; JIN, M. Characterization of Streptococcus suis isolates from the diseased pigs in China between 2003 and 2007. Veterinary Microbiology, v.137, n.1-2, p.196-201, 2009.
  • WISSELINK, H.J.; SMITH, H.E.; STOCKHOFE-ZURWIEDEN, N.; PEPERKAMP, K.; VECHT, U. Distribution of capsular types and production of muramidase-released protein (MRP) and extracellular factor (EF) of Streptococcus suis strains isolated from diseased pigs in seven European countries. Veterinary Microbiology, v.74, n.3, p.237-248, 2000.
  • WISSELINK, H.J.; JOOSTEN, J.J.; SMITH, H.E. Multiplex PCR assays for simultaneous detection of six major serotypes and two virulence-associated phenotypes of Streptococcus suis in tonsillar specimens from pigs. Journal of Clinical Microbiology, v.40, n.8, p.2922-2929, 2002.
  • YANG, J.; JIN, M.; CHEN, J.; YANG, Y.; ZHENG, P.; ZHANG, A.; SONG, Y.; ZHOU, H.; CHEN, H. Development and evaluation of an immunochromatographic strip for detection of Streptococcus suis type 2 antibody. Journal of Veterinary Diagnostic Investigation, v.19, n.4, p.355-361, 2007.
  • YE, C.;  ZHU, X.; JING, H.; DU, H.; SEGURA, M.; ZHENG, H.; KAN, B.; WANG, L.; BAI, X.; ZHOU, Y.; CUI, Z.; ZHANG, S.; JIN, D.; SUN, N.; LUO, X.; ZHANG, J.; GONG, Z.; WANG, X.; WANG, L.; SUN, H.; LI, Z.; SUN, Q.; LIU, H.; DONG, B.; KE, C.; YUAN, H.; WANG, H.; TIAN, K.; WANG, Y.; GOTTSCHALK, M; XU, J. Streptococcus suis sequence type 7 outbreak, Sichuan, China. Emerging Infectious Diseases, v.12, n.8, p.1203-1208, 2006.
  • ZHANG, C.P.; NING, Y.B.; ZHANG, Z.Q.; SONG, L.; QIU, H.S.; GAO, H.Y.; FAN, X.Z. Prevalence of Streptococcus suis isolated from clinically healthy sows in China. Agricultural Science in China, v.8, n.5, p.638-642, 2009.

Datas de Publicação

  • Publicação nesta coleção
    07 Jul 2015
  • Data do Fascículo
    Set 2013


  • Recebido
    27 Set 2011
  • Aceito
    24 Jun 2013
Instituto Biológico Av. Conselheiro Rodrigues Alves, 1252 - Vila Mariana - São Paulo - SP, 04014-002 - São Paulo - SP - Brazil