This paper focuses on microgenetic analysis as a methodological approach that is inscribed in a historico-cultural and semiotic interpretation of human processes, and is distinct from forms of micro-event analysis connected to other theoretical frameworks. The purpose is to characterize, within the historico-cultural perspective, the trends which articulate the microgenetic level of social interactions to the exam of dialogical-discursive functioning and with propositions of the semiotic-indiciary paradigm. Such trends are very seen as very promising for the investigation of the constitution of the subject, since they enrich the study of intersubjective processes and expand the possibilities of relating details and indicial aspects of specific episodes to macro-social conditions concerning social practices.