The aim of the present study was to evaluate the effect of a synthetic analogue of PGF2 (sodium cloprostenol) associated to carbetocin or oxytocin on the efficiency of farrowing induction in swine. In Experiment I, 284 females were distributed in four treatments: - cloprostenol; - cloprostenol and 0.10mg of carbetocin; - cloprostenol and 10UI of oxytocin; and saline solution. In Experiment II, 276 females were distributed in four treatments: cloprostenol; cloprostenol and 0.10mg of carbetocin; cloprostenol and 0.05mg of carbetocin; and cloprostenol and 10UI of oxytocin. Farrowing induction was performed at 113 days of gestation using an injection of 0.175mg cloprostenol by vulvar submucosal route. Carbetocin or oxytocin was administered 24h after cloprostenol, by intramuscular route. The interval induction-farrowing was shorter (P<0.05) in groups with cloprostenol compared to the group without farrowing induction. Cumulative farrowing, within 26h and 28h after cloprostenol administration, was higher (P<0.05) when carbetocin or oxytocin was used. The use of carbetocin resulted in a shorter (P<0.05) farrowing length. In experiment I, higher stillbirth rate (P<0.05) was observed with the use of carbetocin or oxytocin compared to group without farrowing induction. Furthermore, stillbirth rate was higher (P<0.05) with cloprostenol + carbetocin than with cloprostenol alone. In experiment II, there was no difference (P>0.05) in stillbirth rate among treatments. The use of oxytocic drugs, in association with cloprostenol, results in anticipated and more synchronized farrowings. Following the use of carbetocin in association with cloprostenol, occurs a reduction in farrowing length and 99% or more of farrowings take place within 4h after carbetocin administration, regardless of the dose used.
obstetric intervention; reproduction; sows
