The impact of <i>Apocynum venetum</i> tea flavonoids on G422 glioma <i>in vivo</i>

ZENG, Shi; ZHAO, Xin; HUO, Jianhong; YANG, Huajiang; YANG, Donghong; LIU, Li

doi:10.1590/fst.84322

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Original Article • Food Sci. Technol 42 • 2022 • https://doi.org/10.1590/fst.84322 copy

The impact of Apocynum venetum tea flavonoids on G422 glioma in vivo

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Abstract

This study looked at the inhibitory effects of Apocynum venetum tea flavonoids extract (AVTFE) on mouse glioma G422 cells. Through the use of high performance liquid chromatography, the flavonoids in AVTFE were examined (HPLC). Meanwhile, mice were injected with glioma G422 cells to create a mouse model of a transplanted tumor. AVTFE might significantly (P < 0.05) lower serum sIL-2R content and raise serum IFN-γ content in tumor-bearing mice, according to an analysis of mouse serum. In addition to reducing the rise in spleen weight and spleen index in mice brought on by transplanted tumors, AVTFE can limit the development of transplanted tumors in G422 cell mice. AVTFE can also boost immunity by encouraging T and B lymphocyte proliferation in tumor-bearing animals. AVTFE was therefore verified to have immunomodulatory properties and to limit the proliferation of glioma G422 cells.

Keywords:
Apocynum venetum; tea; G422 cells; glioma; immunity; spleen

Group	Sample dose (mg/kg b.w.)	sIL-2R (pmol/L)
Normal	/	24.16 ± 2.34^D
Model	/	73.58 ± 4.11^A
L-AVTFE	50	51.89 ± 3.92^B
H-AVTFE	100	42.35 ± 1.71^C

Group	Sample dose (mg/kg b.w.)	sIL-2R (pmol/L)
Normal	/	1254.59 ± 35.12^A
Model	/	835.78 ± 22.67^D
L-AVTFE	50	912.78 ± 24.65^C
H-AVTFE	100	1081.55 ± 36.42^B

Group	Sample dose (mg/kg b.w.)	Tumor weight (g)	Tumor inhibitory rate (%)
Model	/	2.25 ± 0.27^A	/
L-AVTFE	50	1.73 ± 0.24^B	23.06 ± 7.84^B
H-AVTFE	100	0.83 ± 0.14^C	51.78 ± 7.74^A

Group	Sample dose (mg/kg b.w.)	Spleen weight (mg)	Spleen index rate (mg/g)
Normal	/	128.65 ± 7.62^D	4.01 ± 0.42^C
Model	/	210.55 ± 8.33^A	6.88 ± 0.69^A
L-AVTFE	50	172.05 ± 8.91^B	5.55 ± 0.65^B
H-AVTFE	100	147.31 ± 6.88^C	4.64 ± 0.35^C

Group	Sample dose (mg/kg b.w.)	T lymphocyte OD value	B lymphocyte OD value
Normal	/	0.625 ± 0.034^A	0.595 ± 0.017^A
Model	/	0.471 ± 0.031^D	0.325 ± 0.015^D
L-AVTFE	50	0.525 ± 0.017^C	0.442 ± 0.025^C
H-AVTFE	100	0.590 ± 0.023^B	0.527 ± 0.019^B

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[1] *Corresponding author: 13908376237@163.com; zengshi959@163.com