Food supplement |
Folinic acid |
- |
Antiemetic |
Bromopride |
- |
Oral rehydration salts |
Sodium chloride, anhydrous glucose, potassium chloride, sodium citrate dihydrate |
- |
Food supplement |
B-complex vitamins |
- |
Hypoglycemic agent |
Glibenclamide |
- |
Hypoglycemic agent |
Glicazide |
- |
Antiacid |
Aluminum hydroxide + magnesium hydroxide |
↑ serum calcium levels ↓ serum phosphate levels |
Hypoglycemic agent |
NPH human insulin |
↓ serum potassium levels ↓ serum magnesium levels |
Hypoglycemic agent |
Regular human insulin |
↓ serum potassium levels ↓ serum magnesium levels |
Hypoglycemic agent |
Linagliptin |
↑ serum uric acid levels |
Hypoglycemic agent |
Metformin |
False-positive urine ketones ↓ serum folic acid levels ↓ serum vitamin B12 levels |
Antifungal drug |
Nystatin |
- |
Antiulcer medication |
Omeprazole |
False-positive urine THC ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum bilirubin levels ↓ serum magnesium levels |
Food supplement |
Pyridoxine |
False-positive urine methadone False-positive urine opiates ↑ serum AST levels ↓ serum folic acid levels ↑ serum urobilinogen levels |
|
Treatment of diseases of the blood and blood-forming organs
|
|
Indication
|
Medicine
|
Laboratory change
|
Antiplatelet agent |
Acetylsalicylic acid |
↑ serum glucose levels Larger doses (1.3 g four times a day): ↑ urinary excretion and ↓ serum uric acid levels Smaller doses (< 325 mg three times a day): ↓ urinary excretion and ↑ serum uric acid levels ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ urinary VMA levels ↓ serum TSH levels High doses: ↑ prothrombin time |
Food supplement |
Folic acid |
High continuous doses: ↓ serum levels of B-complex vitamins (B1, B2, B3, B5, B6, B7, and B12) |
Antiplatelet agent |
Clopidogrel |
↑ serum bilirubin levels ↑ serum AST and ALT levels ↑ serum LDH levels ↑ serum GGT levels ↑ serum total cholesterol levels ↑ serum urea levels ↑ serum uric levels |
Anticoagulant |
Dabigatran |
↓ hemoglobin levels |
Anticoagulant |
Enoxaparin |
↓ hematocrit ↑ serum AST and ALT levels ↑ serum potassium levels |
Anticoagulant |
Heparin |
Thrombocytopenia ↑ serum AST and ALT levels ↑ serum potassium levels ↓ hematocrit |
Antianemic drug |
Iron sulfate |
Fecal occult blood can be obscured by the black color of iron in feces |
Anticoagulant |
Sodium warfarin |
Macroscopic or microscopic hematuria |
Treatment of cardiovascular diseases
|
Indication
|
Medicine
|
Laboratory change
|
Antiarrhythmic |
Amiodarone |
↓ serum T4 levels ↓ serum T3 levels |
Antihypertensive medication Antianginal drug |
Amlodipine |
- |
Antihypertensive medication Antianginal drug Antiarrhythmic |
Atenolol |
↑ serum urea levels ↑ serum LDL-c levels ↓ serum HDL-c levels ↑ serum potassium levels ↑ serum triglyceride levels ↑ serum uric acid levels ↑ ANA titers ↑ serum glucose levels |
Antihypertensive medication |
Captopril |
↑ false-positive urine acetone Neutropenia Agranulocytosis Proteinuria ↑ serum potassium levels ↑ serum urea levels ↑ serum creatinine levels ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum bilirubin levels False-positive ANA |
Antihypertensive medication Antianginal drug |
Carvedilol |
↑ serum urea levels ↑ serum LDL-c levels ↓ serum HDL-c levels ↑ serum potassium levels ↑ serum triglycerides levels ↑ serum uric acid levels ↑ serum glucose levels ↑ ANA titers |
Antihypertensive medication |
Clonidine |
↑ serum glucose levels ↓ concentrations of urinary catecholamines and VMA False-positive Coombs test |
Antiarrhythmic Cardiotonic drug |
Digoxin |
- |
Antihypertensive medication |
Enalapril |
Neutropenia Agranulocytosis ↑ serum potassium levels |
Antihypertensive medication Diuretic |
Spironolactone |
False increase in digoxin levels ↑ serum potassium levels ↓ serum sodium levels ↑ serum magnesium levels ↑ serum uric acid levels ↑ serum urea levels ↑ serum creatinine levels ↑ plasma renin activity ↑ urinary calcium excretion ↑ serum cortisol levels |
Antihypertensive medication Diuretic |
Furosemide |
↑ serum uric acid levels ↑ serum glucose levels ↓ serum potassium levels ↓ serum sodium levels ↓ serum calcium levels ↓ serum magnesium levels ↑ serum urea levels ↑ serum creatinine levels |
Antihypertensive medication |
Hydralazine |
↓ hemoglobin levels Leukopenia Agranulocytosis Thrombocytopenia False-positive direct Coombs test |
Antihypertensive medication Diuretic |
Hydrochlorothiazide |
↓ serum potassium levels ↓ serum chlorine levels ↑ serum calcium levels ↓ serum magnesium levels ↑ serum uric acid levels ↑ serum glucose levels ↑ serum cholesterol levels ↑ serum HDL-c levels ↑ serum triglyceride levels ↑ serum bilirubin levels ↑ serum creatinine levels ↓ serum sodium levels |
Antianginal drug Vasodilator |
Isosorbide dinitrate |
- |
Antianginal drug Vasodilator |
Isosorbide mononitrate |
- |
Antihypertensive medication |
Losartan |
↑ serum urea levels ↑ serum creatinine levels ↑ serum AST and ALT levels ↑ serum bilirubin levels ↑ serum potassium levels |
Antihypertensive medication |
Methyldopa |
False increase in catecholamine levels ↑ serum urea levels ↑ serum creatinine levels ↑ serum potassium levels ↑ serum sodium levels ↑ serum prolactin levels ↑ serum uric acid levels ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum bilirubin levels ↑ prothrombin time False-positive direct Coombs test |
Antihypertensive medication Antianginal drug |
Nifedipine retard |
False-positive ANA and direct Coombs test |
Antihypertensive medication Antianginal drug Antiarrhythmic |
Propranolol |
↑ serum urea levels ↑ serum LDL-c levels ↓ serum HDL-c levels ↑ serum potassium levels ↑ serum triglyceride levels ↑ serum uric acid levels ↑ ANA titers ↓ or ↑ serum glucose levels |
Antilipemic |
Simvastatin |
↑ glycated hemoglobin ↑ serum glucose levels ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum GGT levels ↑ serum bilirubin levels ↑ serum creatine phosphokinase levels |
Treatment of skin conditions
|
Indication
|
Medicine
|
Laboratory change
|
Antifungal agent |
Ketoconazole |
↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum bilirubin levels ↓ serum testosterone levels |
Antifungal agent |
Clotrimazole |
↑ serum AST levels |
Wound cleaning |
Collagenase + chloramphenicol |
- |
Anti-inflammatory |
Dexamethasone |
- |
Painkiller |
Lidocaine |
- |
Antibiotic |
Neomycin + Bacitracin |
- |
Antibiotic |
Potassium permanganate |
- |
Antibiotic |
Silver sulfadiazine |
Agranulocytosis Aplastic anemia Thrombocytopenia Leukopenia Hemolytic anemia |
Treatment of genitourinary tract disorders, sex hormones and immunoglobulins
|
Indication
|
Medicine
|
Laboratory change
|
Contraceptive |
Algestone + estradiol |
- |
|
Anti-RH immunoglobulin |
- |
Contraceptive |
Levonorgestrel |
- |
Contraceptive |
Levonorgestrel + ethinylestradiol |
- |
Contraceptive |
Medroxyprogesterone |
↑ serum alkaline phosphatase levels ↑ serum LDL-c levels ↓ serum HDL-c levels ↑ serum T4 levels ↑ serum T3 levels |
Antiinfective drug |
Metronidazole |
- |
Contraceptive |
Norethisterone |
- |
Contraceptive |
Norethisterone + estradiol |
- |
UTI relief |
Oxybutynin |
- |
Treatment of inflammatory processes and hypothyroidism |
Indication |
Medicine |
Laboratory change |
Hormonal medication |
Levothyroxine sodium |
- |
Anti-inflammatory |
Prednisolone |
↑ serum glucose levels ↓ serum potassium levels ↓ serum calcium levels ↑ serum sodium levels ↑ serum total cholesterol levels ↑ serum LDL-c levels ↑ serum triglyceride levels |
Anti-inflammatory |
Prednisone |
↑ serum glucose levels ↓ serum potassium levels ↓ serum calcium levels ↑ serum sodium levels ↑ serum total cholesterol levels ↑ serum LDL-c levels ↑ serum triglyceride levels |
Systemic anti-infective treatment
|
Indication
|
Medicine
|
Laboratory change
|
Treatment of herpes infection of skin and mucous membranes |
Acyclovir |
↑ serum urea levels ↑ serum creatinine levels ↓ creatinine clearance |
Antibiotic |
Amoxicillin |
↓ hemoglobin levels Hemolytic anemia Leukopenia Agranulocytosis Thrombocytopenia ↑ urine glucose levels |
Antibiotic |
Amoxicillin + clavulanic acid |
Clavulanic acid: false-positive Coombs test ↓ hemoglobin levels Hemolytic anemia Leukopenia Agranulocytosis Thrombocytopenia ↑ urine glucose levels ↑ serum alkaline phosphatase levels ↑ serum LDH levels ↑ serum AST and ALT levels |
Antibiotic |
Azithromycin |
↑ prothrombin time Leukopenia Thrombocytopenia ↑ serum bilirubin levels ↑ serum AST and ALT levels ↑ serum LDH levels ↑ serum alkaline phosphatase levels ↑ serum creatine phosphokinase levels ↑ serum potassium levels ↑ serum urea levels ↑ serum creatinine levels ↑ serum glucose levels |
Antibiotic |
Cefalexin |
False-positive direct Coombs test Neutropenia Thrombocytopenia Eosinophilia ↑ urine glucose levels ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum bilirubin levels ↑ serum LDH levels ↑ serum urea levels ↑ serum creatinine levels |
Systemic anti-infective treatment
|
Indication
|
Medicine
|
Laboratory change
|
Antibiotic |
Ceftriaxone |
False-positive Coombs test ↓ hemoglobin levels Reticulocytosis Hemoglobinuria Eosinophilia Leukopenia Lymphocytosis Prolonged prothrombin time Neutropenia Agranulocytosis Thrombocytopenia ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum bilirubin levels ↑ serum LDH levels ↑ serum urea levels ↑ serum creatinine levels |
Antibiotic |
Ciprofloxacin |
False-positive urine opiates Anemia (including hemolytic and aplastic) Thrombocytopenia Leukopenia Agranulocytosis Pancytopenia ↑ serum AST and ALT levels ↑ serum LDH levels ↑ serum bilirubin levels ↑ serum alkaline phosphatase levels ↑ or ↓ serum glucose levels |
Antibiotic |
Clarithromycin |
↑ serum AST and ALT levels ↑ serum bilirubin levels ↑ serum alkaline phosphatase levels ↑ serum urea levels |
Antibiotic |
Doxycycline |
False increase in urine catecholamine levels ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum bilirubin levels ↑ serum amylase levels |
Antibiotic |
Spiramycin |
- |
Antibiotic |
Erythromycin |
False increase in urine catecholamines ↑ serum bilirubin levels ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels |
Systemic anti-infective treatment
|
Indication
|
Medicine
|
Laboratory change
|
Antifungal agent |
Fluconazole |
↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum bilirubin levels |
Antifungal agent |
Itraconazole |
↓ serum potassium levels |
Antifungal agent |
Metronidazole |
↑ serum AST and ALT levels ↑ serum LDH levels ↑ serum triglyceride levels |
Antibiotic |
Nitrofurantoin |
False-positive urine glucose ↑ serum bilirubin levels ↑ serum alkaline phosphatase levels ↑ serum urea levels ↑ serum creatinine levels |
Antibiotic |
Norfloxacin |
|
Antibiotic |
Benzathine penicillin |
False-positive direct Cooms test False-positive urine glucose using Benedict's reagent Hemolytic anemia Agranulocytosis Leukopenia Neutropenia ↑ Proteinuria ↑ serum potassium levels after large doses ↑ serum sodium levels after large doses ↑ serum AST and ALT levels ↑ serum LDH levels ↑ serum alkaline phosphatase levels |
Antibiotic |
Benzathine penicillin + procaine |
- |
Antitubercular agent Antibiotic |
Rifampicin |
- |
Antibiotic |
Sulfadiazine |
↑ serum urea levels ↑ serum creatinine levels Hematuria Proteinuria Crystalluria |
Systemic anti-infective treatment
|
Indication
|
Medicine
|
Laboratory change
|
Antibiotic |
Sulfamethoxazole + trimethoprim |
False increase in creatinine levels False increase in methotrexate levels ↑ serum bilirubin levels ↑ serum potassium levels ↑ serum creatinine levels ↑ serum alkaline phosphatase levels |
Treatment of musculoskeletal disorders
|
Indication
|
Medicine
|
Laboratory change
|
Osteoporosis treatment |
Alendronate sodium |
- |
Treatment of gouty arthritis and hyperuricemia |
Allopurinol |
↓ serum and urinary levels of uric acid ↑ serum alkaline phosphatase levels ↑ serum bilirubin levels ↑ serum AST and ALT levels ↓ erythrocytes Thrombocytopenia ↑ serum urea levels ↑ serum creatinine levels ↓ creatinine clearance |
Muscle relaxant |
Baclofen |
↑ serum glucose levels ↑ serum alkaline phosphatase levels ↑ serum AST and ALT levels |
Anti-inflammatory |
Diclofenac sodium |
↓ hemoglobin levels ↓ hematocrit ↓ serum alkaline phosphatase levels ↓ serum LDH levels ↑ serum AST and ALT levels ↑ serum urea levels ↓ serum creatinine levels |
Anti-inflammatory |
Ibuprofen |
↓ hemoglobin levels ↓ hematocrit Leukopenia Thrombocytopenia ↓ creatinine clearance ↑ bleeding time ↑ serum potassium levels ↑ serum urea levels ↑ serum creatinine levels ↑ serum alkaline phosphatase levels ↑ serum LDH levels ↑ serum AST and ALT levels ↓ serum glucose levels |
Treatment of nervous system diseases and sleep disorders
|
Indication
|
Medicine
|
Laboratory change
|
Anticonvulsant |
Valproic acid |
False-positive urine ketone Thrombocytopenia Leukopenia ↑ serum AST and ALT levels |
Anxiolytic |
Alprazolam |
↓ hematocrit Neutropenia |
Antidepressant |
Amitriptyline |
↑ serum bilirubin levels ↑ serum alkaline phosphatase levels ↑ or ↓ serum glucose levels |
Antiparkinsonian drug |
Biperiden |
- |
Antidepressant |
Bupropion |
False-positive urine amphetamine |
Anticonvulsant |
Carbamazepine |
False increase of perphenazine levels False-positive tricyclic antidepressant results Pancytopenia False-negative hCG results Thrombocytopenia Leukopenia ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum bilirubin levels ↑ serum urea levels ↓ serum sodium levels ↑ serum cholesterol levels ↑ serum HDL-c levels ↑ serum triglyceride levels Proteinuria Glycosuria |
Mood stabilizer |
Lithium carbonate |
↑ serum sodium levels |
Antidepressant |
Clomipramine |
Leukopenia Agranulocytosis Thrombocytopenia Anemia Pancytopenia ↑ serum ALT and AST levels ↑ or ↓ serum glucose levels |
Anxiolytic |
Clonazepam |
↑ serum bilirubin levels ↑ serum AST and ALT levels |
Antipsychotic |
Chlorpromazine |
False-positive phenylketonuria test False-positive salicylate in urine False-negative or-positive hCG results False-positive urine bilirubin Neutropenia Agranulocytosis ↓ hematocrit ↓ hemoglobin levels Leukopenia ↓ granulocytes Thrombocytopenia ↑ serum prolactin levels ↑ serum bilirubin levels ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels |
Anxiolytic |
Diazepam |
- |
Painkiller Antipyretic |
Dipyrone |
- |
Anticonvulsant |
Phenytoin |
False-positive urine barbiturates Thrombocytopenia Leukopenia Agranulocytosis Pancytopenia ↓ serum T4 levels It can produce below normal dexamethasone suppression test ↑ serum glucose levels ↑ serum alkaline phosphatase levels ↑ serum GGT levels |
Anticonvulsant |
Phenobarbital |
False increase in pentobarbital levels ↓ serum bilirubin levels |
Antidepressant |
Fluoxetine |
Proteinuria ↑ serum alkaline phosphatase levels ↑ serum ALT and AST levels ↑ serum urea levels ↑ serum creatine phosphokinase levels ↑ or ↓ serum glucose levels ↓ serum calcium levels ↓ serum sodium levels ↓ serum uric acid levels |
Anxiolytic |
Flurazepam |
- |
Antipsychotic |
Haloperidol |
↑ serum prolactin levels ↓ serum cholesterol levels Leukopenia Neutropenia Agranulocytosis |
Antipsychotic |
Haloperidol decanoate |
- |
Antidepressant |
Imipramine |
↑ or ↓ serum glucose levels |
Antiparkinsonian drug |
Levodopa + benserazide |
False-negative urine glucose False-positive urine ketone False increase in catecholamines and their metabolytes in urine and plasma False-positive Coombs test |
Antiparkinsonian drug |
Levodopa + carbidopa |
False-negative urine glucose False-positive urine ketone Falsely high levels of catecholamines and their metabolytes in urine and plasma False-positive Coombs test ↓ hemoglobin levels ↓ hematocrit Agranulocytosis Hemolytic and non-hemolytic anemia Thrombocytopenia Leukocitosis ↑ serum glucose levels ↑ serum AST and ALT levels ↑ serum bilirubin levels ↑ serum alkaline phosphatase levels ↑ serum LDH levels ↑ serum protein-bound iodine levels ↓ serum urea levels ↓ serum creatinine levels ↓ serum uric acid levels |
Antipsychotic |
Levomepromazine |
- |
Reduces smoking withdrawal symptoms |
Nicotine |
- |
Anxiolytic |
Nitrazepam |
- |
Antidepressant |
Nortriptyline |
↑ serum bilirubin levels ↑ serum alkaline phosphatase levels ↑ or ↓ serum glucose levels |
Anticonvulsant |
Oxcarbazepine |
↓ serum sodium levels |
Painkiller Antipyretic |
Paracetamol |
False increase in serum uric acid levels False-positive urine 5-hydroxyindoleacetic acid ↑ serum ALT and AST levels ↑ serum bilirubin levels ↑ serum LDH levels ↑ prothrombin time False decrease of serum glucose levels |
Antidepressant |
Sertraline |
False-positive urine benzodiazepines ↓ serum uric acid levels |
Antipsychotic |
Thioridazine |
False-positive urine salicylate False-positive or false-negative hCG results False-positive urine bilirubin ↓ hematocrit ↓ hemoglobin levels Leukopenia ↓ granulocytes Thrombocytopenia ↑ serum bilirubin levels ↑ serum AST and ALT levels ↑ serum alkaline phosphatase levels ↑ serum prolactin levels |
Anticonvulsant |
Topiramate |
↓ serum phosphate levels ↓ serum potassium levels ↑ serum alkaline phosphatase levels ↑ serum AST and ALT levels |
Anxiolytic |
Valeriana officinalis
|
- |
Treatment of parasitic diseases
|
Indication
|
Medicine
|
Laboratory change
|
Antiparasitic |
Albendazole |
Leukopenia ↑ serum AST and ALT levels |
Antiparasitic |
Ivermectin |
Leukopenia Eosinophilia ↑ hemoglobin levels ↑ serum AST and ALT levels |
Antiparasitic |
Mebendazole |
Leukopenia Thrombocytopenia ↓ hemoglobin levels Neutropenia (including agranulocytosis) ↑ serum urea levels transitorily ↑ serum AST and ALT levels transitorily ↑ serum alkaline phosphatase levels transitorily |
Antiparasitic |
Permethrin |
- |
Antiparasitic |
Pyrimethamine |
↓ serum folic acid levels ↓ serum vitamin B12 levels Leukopenia Thrombocytopenia Pancytopenia Megaloblastic anemia |
Treatment of respiratory diseases
|
Indication
|
Medicine
|
Laboratory change
|
Bronchodilator |
Aminophylline |
False decrease in phenobarbital levels |
Anti-inflammatory |
Beclomethasone |
- |
Anti-inflammatory |
Budesonide |
- |
Nasal decongestant |
Sodium chloride |
- |
Antihistamine |
Loratadine |
- |
Antihistamine |
Promethazine |
False-positive salicylate in urine False-positive or false-negative hCG results Leukopenia Agranulocytosis ↑ serum glucose levels |
Bronchodilator |
Salbutamol |
↓ serum potassium levels |