Variability in the clinical distributions of Candida species and the emergence of azole-resistant non-Candida albicans species in public hospitals in the Midwest region of Brazil

Karine Mattos Luana Carbonera Rodrigues Kelly Mari Pires de Oliveira Pedro Fernando Diniz Luiza Inahê Marques Adriana Almeida Araujo Marilene Rodrigues Chang About the authors

Abstract

INTRODUCTION

Incidence and antifungal susceptibility of Candida spp. from two teaching public hospitals are described.

METHODS

The minimum inhibitory concentrations of fluconazole, voriconazole, itraconazole, and amphotericin B were determined using Clinical Laboratory Standard Institute broth microdilution and genomic differentiation using PCR.

RESULTS

Of 221 Candida isolates, 50.2% were obtained from intensive care unit patients; 71.5% were recovered from urine and 9.1% from bloodstream samples. Candida parapsilosis sensu stricto was the most common candidemia agent.

CONCLUSIONS

We observed variations in Candida species distribution in hospitals in the same geographic region and documented the emergence of non-C. albicans species resistant to azoles.

Keywords:
Candidiasis; Candidemia; Epidemiology

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