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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.34 no.5 São Paulo Sept./Oct. 1992 



Aplastic crisis due to human parvovirus B19 infection in hereditary hemolytic anaemia


Crise aplástica devido à infecção por parvovirus humano B19 em anemia hemolítica hereditária



R. C. N. CubelI; M. C. ValadãoII; W. V. PereiraII; M. C. MagalhãesIII; J. P. NascimentoI

IDepartamento de Virologia, Instituto Oswaldo Cruz, FIOCRUZ, RJ
IIServiço de Hematologia, Hosp. Universitário, UFSM, RS
IIIServiço de Hematologia, Hosp. Gafrée-Guinle, UNIRIO, RJ

Correspondence to




Specific anti-B19 IgM was demonstrated in sera from three children showing transient aplastic crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the crisis during August, 1990. Two siblings living in Santa Maria, RS, developed aplastic crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed aplastic crisis no IgM anti-B19 was detected in her sera.

Keywords: Human parvovirus B19; Transient aplastic crisis; Hereditary spherocytosis; Sickle-cell disease


IgM específica anti-B19 foi demonstrada nos soros de três crianças apresentando aplasia transitória de medula. Um menino de dois anos de idade vivendo no Rio de Janeiro e sendo portador de anemia falciforme, apresentou a crise durante Agosto de 1990. Dois irmãos vivendo em Santa Maria - RS, desenvolveram crise de aplasia em Maio de 1991, quando foram também diagnosticados como portadores de microesferocitose. IgM anti-B19 não foi detectada no soro de uma terceira criança, desta mesma família, a qual primeiramente apresentou crise de aplasia.



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We thanks Dr. M. J. Andrada-Serpa for her help in the preparation of this paper. R. C. N. Cubel is receiving a CNPq fellowship due to her PhD course at the Instituto de Microbiologia, UFRJ.



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Correspondence to:
R. C. N. Cubel
Dept. Virologia, FIOCRUZ
Av. Brasil 4365,21045, Rio de Janeiro, Brasil

Recebido para publicação em 30/1/1992
Aceito para publicação em 4/5/1992

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