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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.35 no.2 São Paulo Mar./Apr. 1993 



Chronic gastritis and Helicobacter pylori in digestive form of Chagas' disease


Gastrite crônica e Helicobacter Pylori na forma digestiva da doença de Chagas



A. J. A. Barbosa; D. M. M. Queiroz; A. M. M. F. Nogueira; M. J. A. Roquette Reis; E. N. Mendes; G. A. Rocha; L. M. F. RomanelloI; L. E. A. TronconI

IDepartamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, SP, Brasil

Address for correspondence




Patients with the digestive form of Chagas'disease frequently present chronic gastritis. As the microorganism Helicobacter pylori is now accepted as the most common cause of human chronic gastritis, the present work was undertaken to verify a possible relationship between the presence of this bacterium and inflammatory changes of antral mucosa in chagasic patients. Seventeen chagasics, with megaesophagus and or megacolon were studied. Fragments from two different regions of antral mucosa were obtained by endoscopy, fixed in 4% neutral formaldehyde and embedded in paraffin. The sections were stained by haematoxylin and eosin for histology analysis, and by carbolfuchsin for H. pylori identification. H. pylori was found in 16 (94.1%) chagasic patients, all of them presenting chronic gastritis. Superficial gastritis was seen in 9 (52.9%) while atrophic gastritis was present in 8 (47.1%) patients. H. pylori was present on gastric mucosa of 8 (100%) patients with atrophic gastritis and of 8 (88.8%) patients with superficial gastritis. We concluded that the microorganism H. pylori should be considered a possible factor connected with the etiopathogenesis of chronic superficial and atrophic gastritis frequently observed in patients with the digestive form of Chagas' disease.

Key words: Chagas' disease; Megaesophagus; Megacolon; Chronic gastritis; H. pylori.


Pacientes com a forma digestiva da doença de Chagas frequentemente apresentam gastrite crônica. Tendo em vista que o microrganismo Helicobacter pylori é hoje considerado a causa mais comum de gastrite crônica no homem, propôs-se a realização deste trabalho para se verificar a possibilidade de esta bactéria estar também associada com as alterações inflamatórias da mucosa gástrica em pacientes com a forma digestiva da doença de Chagas. Fragmentos de duas regiões diferentes da mucosa antral foram obtidos endoscopicamente de 17 pacientes chagásicos com megaesôfago e ou megacolon. Os fragmentos foram processados rotineiramente para inclusão em parafina e cortes de 5 |im de espessura foram corados pela H & E para análise histológica e pela carbolfucsina para a identificação do H. pylori. A bactéria foi encontrada em 16 (94,1%) pacientes, todos eles apresentando gastrite crônica. Gastrite crônica superficial foi observada em 9 (52,9%) enquanto que gastrite crônica atrófica estava presente em 8 (47,1%) pacientes. H. pylori estava presente em todos os pacientes com gastrite crônica atrófica e em 8 (88, 8%) pacientes com gastrite crônica superficial.
Conclue-se que o microrganismo H. pylori deve ser considerado como possível fator ligado à etiopatogênese da gastrite crônica superficial e atrófica frequentemente observadas em pacientes com a forma digestiva da doença de Chagas.



Full text available only in PDF format.

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The authors are indebted to Dr. J. L. P. Modena, Head of the Section of Digestive Tract Endoscopy of the University Hospital of Ribeirão Preto who allowed us to use the endoscopic equipment. The authors are also indebted to FAPEMIG/ FINEP/CNPq for the financial support received.



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Address for correspondence:
Dr. Alfredo J.A. Barbosa
Faculdade de Medicina UFMG
Av. Alfredo Balena, 190
CEP 30130 -Belo Horizonte/MG, Brasil

Recebido para publicação em 13/3/1992
Aceito para publicação em 3/3/1993

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