A lipid study of schistosomotic young people underwent surgical treatment

Objective: To evaluate the lipid metabolism in a population of young people, with the hepatesplenic form of schistosomiasis mansoni, associated with bleeding esophageal varices. Methods: 20 young patients were selected, at random, and compared to a control group of 20 healthy young people with the same social, economical and environmental conditions. The patients had undergone splenectomy, ligature of the left gastric vein and auto implantation of spleen tissue into the major omentum. From these two groups were obtained plasma and erythrocytes, and it were extracted, separated and determinated the neutral lipids, free cholesterol and ester, phospholipids and triglicerides levels. Results: The results appointed that the total molar concentration of total, cholesterol was similar to the group of the patients, which was similar to the control group. Similar results were observed with the fractions of ester and free cholesterol. There was a reduction on the concentration of plasmatic triglicerides, but without significance. The individual's phospholipids presented relative concentration, similar to the control group, but there was significant reduction (p<0,01) in the patient's phosphatidilethanolamine fraction, however, there was no significantly reduction of molar concentration of total plasmatic phospholipids, compared to the controls. In the erythrocyte membrane, the total cholesterol and. total phospholipids levels do not suffered significant alterations. Conclusion: The obtained data indicated a similarity of the lipids levels in the plasma and in the erythrocyte membrane of the patients submitted to the surgical treatment.

Hepatosplenic schistosomiasis mansoni; Lipids; Cholesterol; Phospholipids

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia Al. Rio Claro, 179/141, 01332-010 São Paulo SP Brazil, Tel./Fax: +55 11 3287-8814 - São Paulo - SP - Brazil
E-mail: sgolden@terra.com.br