Can Triamcinolone acetonide, platelet-rich plasma, and pentosan polysulfate sodium induce oxidative stress in cultured equine chondrocytes?

Acetonido de triancinolona, plasma rico em plaquetas e pentosano polissulfato sódico podem ocasionar estresse oxidativo em cultivo de condrócitos de equinos?

Heloisa Einloft Palma Miguel Gallio Gabriele Biavaschi da Silva Camila Cantarelli Patrícia Wolkmer Rodrigo Fernando dos Santos Salazar Julien Wergutz Luciana Maria Fontanari Krause Alexandre Krause Karin Erica Brass Flavio Desessards De La Corte About the authors

ABSTRACT:

Progressive deterioration and loss of articular cartilage are the final degenerative events common to osteoarthritis (OA). Reactive oxygen species (ROS) play an important role in this chondrocyte catabolic activity, leading to cell death and matrix components breakdown. Intra-articular corticosteroid injections such as triamcinolone acetonide have been used to control pain and inflammation associated with OA. New treatments for OA, platelet-rich plasma and pentosan polysulphate sodium have also been used and further investigations are necessary to determine their safety in joint cells. In this in vitro study, the use of these three substances (triamcinolone acetonide, platelet-rich plasma, and pentosan polysulphate sodium) in healthy chondrocytes did not alter the antioxidant status when compared to control groups, indicating that they could be considered safe in healthy conditions.

Key words:
antioxidant enzymes; catalase; glutathione peroxidase; lipid peroxidation

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