Systemic and neurotoxic effects of epidural meloxicam in rabbits

Efeitos sistêmicos e neurotóxicos do meloxicam por via epidural em coelhos

Gracineide da Costa Felipe Fernanda Vieira Henrique Renato Otaviano do Rego Alane Pereira Alves Kalyne Danielly Silva de Oliveira Millena de Oliveira Firmino Lylian Karlla Gomes de Medeiros Gustavo de Assis Silva Luanna Figueirêdo Batista Antônio Flávio Medeiros Dantas Bonifácio Benicio de Souza Pedro Isidro da Nóbrega NetoAbout the authors

ABSTRACT:

The aim of this study was to assess systemic and neurotoxic changes following an epidural administration of meloxicamin to rabbits. Twelve adult rabbits four males and eight females; average mass, 1.9 ± 0.1kg were randomly divided into two groups: a control group (GC), which received a single dose of 0.9% NaCl epidurally in a volume of 0.3mL kg-1and a meloxicam group (GM), which received 0.2mg kg-1 meloxicam epidurally along with 0.9% NaCl in a total volume of 0.3mL kg-1. Heart rate, respiratory rate, body temperature, and neurological abnormalities were assessed prior to administration of anesthesia (H0), 1, 2, 3, 6, 12, and 24h following epidural puncture (H1, H2, H3, H6, H12, and H24, respectively), and every 24h afterward for 10 days after epidural puncture (D2, D3, D4, D5, D6, D7, D8, D9, and D10). The surface temperature of lumbosacral region was also measured at H0, H1, H6, H12, H24, D5 and D10. Three animals from each group were euthanized on days 15 and 30 after epidural puncture to assess possible spinal injuries. Variances observed in physiological parameters were not suggestive of adverse effects of meloxicam, as all were within the reference standards, and there were no physical or behavioral changes observed. Neurological function was similar between groups, with only difference between baseline values and values 1h after epidural administration in both groups. There were no histopathological changes in the GM group, and only one animal showed discrete lymphocytic infiltrate. Epidural lumbosacral administration of meloxicam at a dose of 0.2mg kg-1 caused no significant systemic or neurotoxic effects in rabbits.

Key words:
anti-inflammatory; leporids; spinal cord; neurotoxicity

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