Further development of the baboon as a model for acute schistosomiasisAbstract
Baboons develop a syndrome, including eosinophilia and transient fever, after infection with carcariae of Schistosoma mansoni that is consistent with the human syndrome of acute schistosomiasis. Radiotelemetry can be used to follow the course of fever in infected baboons. Individual variations in intensity of disease were noted in baboons. These symptoms and signs were more closely linked to the onset of oviposition by the newly matured worms than they were to the presence of migrating schistosoma or maturing worms. The baboon is concluded to be a suitable and useful model for human acute schistosomiasis mansoni.
Schistosoma mansoni; experimental model; acute stage; baboon
Further development of the baboon as a model for acute schistosomiasis
Raymond T. Damian1
Miguel A. de la Rosa1
Daniel J. Murfin1
Clarence A. Rawlings2
Peter J. Weina3
Yang Ping Xue1
University of Georgia, Department of Zoology, Athens, U.S.A
University of Georgia, Department of Small Animal Medicine, Athens, U.S.A
Walter Reed Army Institute of Research, Division of Experimental Therapeutics, Department of Parasitology, Washington, U.S.A
Baboons develop a syndrome, including eosinophilia and transient fever, after infection with carcariae of Schistosoma mansoni that is consistent with the human syndrome of acute schistosomiasis. Radiotelemetry can be used to follow the course of fever in infected baboons. Individual variations in intensity of disease were noted in baboons. These symptoms and signs were more closely linked to the onset of oviposition by the newly matured worms than they were to the presence of migrating schistosoma or maturing worms. The baboon is concluded to be a suitable and useful model for human acute schistosomiasis mansoni.
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Publication Dates
-
Publication in this collection
04 June 2009 -
Date of issue
1992
