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HIGHLIGHTS Most of carbapenem resistant Morganellaceae are NDM-producer. Morganellaceae resistant to ceftazidime-avibactam cannot me treated with polymyxins.

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HIGHLIGHTS Grape residue extract maintains survival, follicular development and GSH levels. Grape residue extract (0.4 mg/mL) improves mitochondrial activity. Grape residue extract (0.4 mg/mL) promotes meiotic resumption. Grape extract can be an alternative supplement for the in vitro oocyte development.

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HIGHLIGHTS Acute sodium bicarbonate (SB) supplementation increased exercise test duration by ~9.6%. No significant changes in blood pressure or heart rate were observed with SB. Both SB and placebo conditions showed ~15% reductions in blood glucose after exercise. SB was safe, well tolerated, and effective, with no significant adverse effects reported.

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HIGHLIGHTS EGCG reduced the expression of NF-κB and TNF-α proteins EGCG reduced muscle tissue damage

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HIGHLIGHTS ODT are fast-disintegrating and don't require swallowing or water intake. In Brazil, ODT are rarely prescribed despite their convenience. 50 valid ODT registrations were found in Brazil, mainly antiemetics and antidepressants. Common excipients include microcrystalline cellulose and mannitol for masking flavor.

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HIGHLIGHTS The micelles exhibited spherical morphology, hydrodynamic diameters ranging from 95 to 260 nm, and good colloidal stability with a low critical micelle concentration (CMC) of 0.0114 mg/mL. Flaxseed-loaded micelles showed potent concentration-dependent cytotoxicity against MCF-7 cell line, with IC50 values of 0.08 μg/mL (24 h) and 0.096 μg/mL (48 h). Flaxseed-loaded micelles significantly inhibited MCF-7 cell migration, reducing wound closure to 1.7% at IC50 after 48h. The study highlights the potential of phytochemicals-based polymeric micelles as a promising and biocompatible nanocarrier system for breast cancer treatment.

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HIGHLIGHTS EGCG, which has become more important with recent studies and attracting attention with its many biological activities and various molecular targets, is widely used in traditional and modern medicine. EGCG applied for four weeks reduced testicular tissue damage. EGCG is used to scavenge reactive oxygen species by reducing oxidative stress. Cisplatin caused pathological changes, apoptosis and oxidative stress in reproductive tissues.

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HIGHLIGHTS Proposal of a New Methodology, the Normalized Impact Methodi Ordinatio (NI Methodi Ordinatio), a novel enhancement to the original Methodi Ordinatio. Addressing Interdisciplinary Bias, since using Impact Factor (IF) alone in interdisciplinary bibliographic portfolios can introduce bias due to the variation in metric scales across fields like Social Sciences, Arts, and Humanities. The use of normalized metrics (SNIP and JCI) is proposed to mitigate these disparities and enhance fairness and comparability. Development of a Predictive Model for SNIP based on JCI, using the SMOReg algorithm, enabling normalization even when SNIP is unavailable. Introduction of RankIn.NI tool for automatically rank papers based on the three variables proposed by Methodi Ordinatio.

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HIGHLIGHTS Photogrammetry with photos captured by a smartphone is a low-cost modality of facial scanning. We investigated if smartphone photogrammetry is accurate to replace colorless CT-scan meshes. This photogrammetry provides lifelike facial meshes whose similar morphology can replace CT-scan. Open-source photogrammetry algorithms perform as accurately as proprietary alternatives.

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HIGHLIGHTS Lantana camara hydroalcoholic extract (LCHA) shows antioxidant and anti-inflammatory potential. LCHA contains lamiide, geniposide, and flavonoid glycosides. LCHA significantly inhibits nitric oxide and lipid body formation in macrophages. The extract notable reduces lipid peroxidation and ROS levels in vitro.

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HIGHLIGHTS There was a significant expression of MMP-26 in nodular goiter and papillary thyroid carcinoma. MMP-26 showed good sensitivity for identifying nodular goiter and papillary thyroid carcinoma. The results suggest the involvement of MMP-26 in the pathogenesis of thyroid tumors. MMP-26 is a promising complementary biomarker for the diagnosis of nodular thyroid lesions.

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HIGHLIGHTS Sustainable alternative for diversification in baking. Hevea brasiliensis flour is rich in proteins, lipids and fibers. Product meets microbiological and mycotoxin standards. Cookies with alternative flour achieve good sensory acceptance.

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HIGHLIGHTS Active silver nanoparticles (AgNPs) were prepared using hexane extract from P. pubescens seeds (HE-PP). HE-PP-mediated silver nanoparticles showed potent activity against oral, phytopathogenic, H. pylori and mycobacterial strains. Consistent antibacterial activities were observed regardless of bacterial resistance profiles. FTIR analysis confirmed reduction of silver ions by bioactive plant compounds. Nanoparticles showed favorable selectivity toward bacteria over human cells.

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HIGHLIGHTS Machine learning models utilizing clinical data can effectively support risk screening for HAM/TSP. ENTPD1 genotypes, which encode the CD39 protein, have low value as genetic biomarkers for predicting HAM/TSP progression in PLwHTLV. Machine learning models can facilitate the prioritization of HTLV carriers, thereby aiding specialist follow-up and management of HAM/TSP.

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Abstract Plumeria pudica Jacq., popularly known as “bridal bouquet,” is a plant from the Apocynaceae family, notable for its abundant latex production. Traditionally, P. pudica has been used in medicinal preparations in Asia and Latin America to treat various ailments. This study aimed to investigate the pro- and anti-inflammatory activities of two distinct fractions of P. pudica latex: the dialysate latex (DLPp) and the latex protein fraction (LPPp). These activities were evaluated using a paw edema model in mice. Promethazine hydrochloride (PromH) was used to modulate DLPp-induced inflammation, and the anti-inflammatory potential of DLPp was further tested against carrageenan-induced inflammation. Additionally, the phytochemical profiles, total phenol, flavonoid, and protein contents, as well as histamine concentrations in both fractions, were analyzed. DLPp induced a dose-dependent pro-inflammatory response within the first 30 minutes, which was significantly inhibited by both PromH and LPPp. Biochemical analyses revealed the presence of histamine-like molecules in DLPp. LPPp did not elicit pro-inflammatory effects, whereas DLPp failed to suppress carrageenan-induced inflammation. These findings demonstrate that P. pudica latex contains both pro- and anti-inflammatory components, segregated into distinct molecular fractions. To the best of our knowledge, this is the first report describing the pro-inflammatory activity of the low molecular weight latex fraction (DLPp) from Plumeria pudica.

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Abstract This study aimed to explore the relationships between sociodemographic factors, clinical variables, and oral hygiene status in COVID-19 patients and examine their association with disease severity, mortality, and hospital discharge. The case-control study was conducted from March to October 2021 at a university hospital. The study included 112 hospitalized patients, divided into two groups: 68 COVID-19-positive and 44 COVID-19-negative patients. Oral hygiene was assessed using the Critical Patient Oral Hygiene Index (CPOHI), and clinical data such as comorbidities, ventilation type, and lung involvement were extracted from medical records. The study found that COVID-19 positive patients were younger, had greater lung involvement, and were more likely to require mechanical ventilation compared to the control group. A higher number of remaining teeth and better dentition status were associated with better clinical outcomes, including hospital discharge. Poor oral hygiene, as indicated by higher CPOHI scores, was associated with worse outcomes, including longer ICU stays, greater lung involvement. This study highlights the significant impact of oral health on the prognosis of hospitalized COVID-19 patients, underscoring the need for improved oral hygiene management in clinical settings to enhance patient outcomes. Further research is needed to explore the long-term effects of oral care on hospitalized patients.

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Abstract Plant-derived natural products have attracted considerable interest for their potential to promote longevity and healthy aging through bioactive phytochemicals. This study evaluated the effects of Prunus mahaleb L. leaf and seed extracts on the chronological lifespan of Saccharomyces cerevisiae. Extracts of Salix alba L. bark, a known geroprotective plant, were used as a comparative control. Various solvent-based extracts were prepared and tested for cytotoxicity, growth modulation, and longevity-enhancing effects. Extreme-calorie restriction (E-CR) conditions were employed as a reference intervention. The cytotoxicity of extracts varied by solvent polarity, with methanol and water extracts showing low toxicity at concentrations up to 10 mg/mL, while hexane extracts, especially from mahaleb leaves, exhibited high toxicity with LC50 values as low as 0.54 mg/mL. Acetone extracts displayed intermediate toxicity profiles. In lifespan assays, polar extracts from both leaves and seeds significantly extended lifespan, exceeding the effects of both E-CR and S. alba extracts. Acetone extracts also improved survival at low doses, while hexane extracts showed limited or no benefit. GC-MS profiling identified coumarin, squalene, and phytol among the potentially active compounds. These findings demonstrate that P. mahaleb extracts can enhance yeast lifespan under nutrient-deprived conditions without inducing cytotoxicity and support their potential as plant-based candidates for future geroprotective strategies. Further studies are needed to elucidate the underlying molecular mechanisms and to evaluate their effects in higher organisms.

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HIGHLIGHTS Induction of obesity in rats was done using a high-fat diet (HFD) and tap water containing 25% sucrose for a duration of 16 weeks. Obese control group exhibited significant increases in body weight, body mass index, waist circumference, dyslipidemia. Increase in cardiac injury markers, oxidative stress, altered adipokine levels, and impaired liver and kidney function in obese group were detected. Obese control group exhibited elevated levels of leptin and reduced levels of adiponectin, reflecting an imbalance in adipokine signaling. Apigenin modulated various signaling pathways involved in lipid metabolism, glucose homeostasis, and adipogenesis, as well as exert protective effects against oxidative stress.

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HIGHLIGHTS • Liposome-encapsulated phages (LEP) effectively target multidrug-resistant K. pneumoniae • LEP prevent bacterial regrowth longer than free phages in ex vivo lung assays • Liposomal delivery provides a “Trojan Horse” mechanism for pulmonary phage therapy • Encapsulation enhances phage stability and enables sustained virion release

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HIGHLIGHTS Seed treatment improves watermelon seedling tolerance to biosaline water. Thiamethoxam enhances seedling vigor under saline stress conditions. Growth regulators and protectants mitigate salt stress effects on seedlings. Water salinity affects seedling development, but treatments improve quality.

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HIGHLIGHTS Severe pollution from wastewater harms the Bogotá River Proteobacteria was the most abundant phyla in the Bogotá River. Proteobacteria Firmicutes and Bacteroidota were the most abundant phyla in the Bogotá River Exiguobacterium artemiae has genetic mechanism to resist heavy metal toxicity and other xenobiotics. Exiguobacterium artemiae is a potential bioremediation candidate due to its resilience and detoxofication.

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HIGHLIGHTS Presence of lipids, lignified and phenolic compounds, starch grains, and alkaloids in Styrax leprosus; Presence of styloids, prismatic crystals, and druses of calcium oxalate; Peltate trichome was observed in the leaf and stem.

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HIGHLIGHTS Oregano essential oil has fungicidal action against Penicillium digitatum. Spraying and nebulization of oregano oil has the potential to inhibit green mold. Oregano essential oil does not affect the quality of Tahiti lime.

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HIGHLIGHTS Water stress reduced germination and vigor, with variation among cultivars. The accumulation of osmoprotectants aided in the response to water deficit. Cultivars showed differences in growth and biomass under drought conditions.

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HIGHLIGHTS Diflubenzuron and its metabolite affect gill enzymes activity Sediment decreases the toxicity of diflubenzuron and p-chloroaniline mixture Diflubenzuron and its metabolite have synergistic toxic effect

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Abstract Gyropsylla spegazziniana is an important pest of yerba mate Ilex paraguariensis, due to its feeding and reproductive habits. It substantially impacts the development of the plant by forming galls in the young leaves and affecting the production and quality of the leaves, resulting in economic loss to the growers. Since yerba mate is consumed in natura, non-chemical ways to control this insect are needed. Previous laboratory studies showed the potential of attract-and-kill devices covered with conidiospores of the entomopathogen Beauveria bassiana to control G. spegazziniana. In this study, we conducted laboratory and field tests to evaluate the potential of two designs of devices (rectangular and roof-shaped) to manage G. spegazziniana populations and their capacity to protect conidiospores from direct sunlight (specially UV-B). We also conducted laboratory tests to evaluate horizontal transmission from living infected individuals and mycosed cadavers to healthy adult insects. Field tests were conducted in February and March, when the insect populations were at their highest annual densities. Attraction and infection levels were similar for both types of dispensers in both the laboratory and field tests. However, conidiospore viability last longer in the roof-shaped dispensers, which shaded the spores from direct sunlight. We also observed in laboratory high levels of horizontal transmission from both infected alive individuals and mycosed cadavers, with mortality rates reaching 87% and 72%, respectively. The results demonstrate the potential of attract-and-kill devices covered with B. bassiana conidiospores to control G. spegazziniana in yerba mate plantations.

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HIGHLIGHTS A temperature control system coded in C++ was implemented via Arduino. Based on simple tests, operators were able to adjust the controller parameters. Implemented controller acted successfully on the temperature variable. High ethanol conversion rate and high final product concentration were obtained.

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HIGHLIGHTS Bioaugmentation enhances tebuthiuron degradation in sandy soil. Pseudomonas strain (M3) boosts CO2 emissions by 42% over control. Fungal strain (M5) shows promise in herbicide bioremediation. Soil amendments and microbial inoculation synergize for remediation.

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HIGHLIGHTS B. pseudomycoides efficiently degrades Catechol up to 600 mg.L-1. Growth and degradation follow the integrated Haldane model. Kinetic parameters guided design of a 10 L aerobic bioreactor. Provides eco-friendly strategy for pharmaceutical wastewater treatment.

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HIGHLIGHTS Mushroom residue boosts annatto seedling germination and growth up to 60% inclusion. Annatto residue supports Pleurotus yields with substitutions up to 80%. Pleurotus strain 16/01 shows superior mushroom productivity and efficiency. Mushroom and annatto residue use cuts costs and supports regional small producers.

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HIGHLIGHTS • Twenty four co-canes were evaluated with four levels of saline irrigation water viz., Control, ECiw ~ 4, 8 and 12 dS m-1. • Co-canes Co 15023, Co 0238, Co 13035 and Co 0118 showed higher salt tolerance potential than other lines and maintain higher physiological traits along with yield. • Co-canes Co 14036, Co 12027, Co 14026 and Co 13034 were highly sensitive towards water salinity. • These co-canes accumulated Na+ ions in range of 0.478 - 1.194 %, while K+ content reduced by 25.09 - 56.27 % under ECiw ~ 4 dS m-1, ECiw ~ 8 dS m-1 and ECiw ~ 12 dS m-1, respectively. • The identified sugarcane lines can be promoted further for detailed farmer field trails and can be included in breeding advancement for propagation.

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HIGHLIGHTS • Formulations of combined essential oil nanoemulsions exhibit significant herbicidal activity. • In vitro assays confirm strong inhibitory effects on seed germination and seedling growth. • A specific three-oil mixture demonstrated superior control of Megathyrsus maximus germination.

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HIGHLIGHTS • Valorization of pearl millet stalk and seeds for green packaging solutions. • CNF incorporation improved thermal stability and modified film microstructure. • CNF:water, (w/w) of 1:500 formulation showed the best balance of mechanical and barrier properties.

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Abstract Pickles, fermented vegetable products, are a source of functionally important microorganisms. In the present study, 360 lactic acid bacteria originating from traditional pickles in Türkiye were evaluated to ascertain their probiotic, safety, and technological properties. Of these, nine were identified as Lactiplantibacillus plantarum, three as Levilactobacillus brevis, and one as Lactiplantibacillus paraplantarum. The 13 isolates demonstrated a survival rate of between 65.12% and 99.91% at 2 hours, and between 62.56% and 99.91% at 3 hours in simulated gastric juice. The isolates also exhibited tolerance to 3% bile salts, with survival rates ranging from 98.15% to 132.17%. The isolates inhibited S. aureus ATCC 29213 and S. Typhimurium RSHMB 95091. In addition, their auto-aggregation levels increased during the incubation period. In addition, two L. plantarum strains exhibited strong bile salt hydrolysis activity, while the majority of the strains demonstrated moderate bile salt hydrolysis activity. The isolates demonstrated resistance to vancomycin, gentamicin, kanamycin and streptomycin, and susceptibility to erythromycin and chloramphenicol. It was observed that none of the isolates possessed virulence genes or genes related to biogenic amine production. In addition, L. plantarum strains were found to possess the gad gene, which is responsible for the production of gamma amino butyric acid. The study concluded that probiotic properties are strain-specific and that these strains are potential probiotic candidates.

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HIGHLIGHTS • Encapsulation aims to protect and promote the controlled release of active ingredients. • The technique has been studied for applications in various contexts. • In pest control, several active ingredients can be encapsulated. • Further studies are needed to scale up and apply the technique in the field.

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HIGHLIGHTS BABT marks 80 years of continuous publication, progressing from its origins at IBPT to an international open-access journal. This volume is dedicated to One Health, integrating human, animal, and environmental health. Free-to-read and free-to-publish policies, together with adoption of a CC BY license, reaffirm the commitment of the journal to open science. The shared history of BABT and TECPAR reflects a longstanding institutional commitment to innovation, scientific communication, and public service.

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HIGHLIGHTS This study innovatively constructed recombinant Bacillus subtilis clones with the CotC::MCP genes. Obtention of a new plasmid (pDGCMCP) for the Bacillus subtilis strain. Contribution towards the development of a vaccine vector against ranavirus utilizing Bacillus subtilis spores.

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HIGHLIGHTS First study using MALDI-TOF to profile microbiota in collared peccaries. Identified pathogenic and zoonotic bacteria in healthy captive peccaries. Five bacterial families were reported for the first time in tayassuids. Findings reinforce One Health relevance of wildlife microbiota monitoring.

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HIGHLIGHTS Standardization of methods for obtaining somatic cells from Holstein cattle milk. SCC was used as a criterion for analyzing differentially expressed genes in milk somatic cells. mRNA quantification of lipogenic and antioxidant genes. SCC in Holstein cow milk can significantly affect the expression of fat metabolism genes.

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HIGHLIGHTS Polymeric nanocapsules enhance antifungal activity and reduce resistance. Potential applications extend to human, animal, and environmental health (One Health). Nanotechnology enables safe, innovative, and sustainable antifungal therapies.

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HIGHLIGHTS Predominance of Proteobacteria in most samples, with notable differences in microbial diversity and composition between upstream and downstream sites. Pseudomonas aeruginosa and Escherichia coli persisted in the aquatic environment surrounding pig farms and cities Detection of pathogenic bacteria such as Escherichia coli O157:H7 and Shigella flexneri 2a in areas influenced by pig farming and urban wastewater discharge.

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HIGHLIGHTS Counterimmunoelectrophoresis is a suitable method for determining rabies antibody titers. The method was standardized and converted into quantitative. Combistats software improves the reliability of the results. Control charts were useful for identifying systematic issues. The method can contribute for One Health approach in rabies surveillance.

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HIGHLIGHTS L-theanine exerts modulator effects on the central nervous system. L-theanine possesses antioxidant effects in the brain. L-theanine enhances cognitive responses. L-theanine does not affect the exploratory activity.

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HIGHLIGHTS Replacement of products in treatments is carried out by 93% of livestock farmers. The combination of acaricides products in the same application is practiced by 33% of livestock farmers. There is a practice of adding to the product dosages in 26% of the Slaughter activity and 41% of the Milk activity. The lineage of the breeds used in each activity, Slaughter or Milk, influences the number of annual applications for controlling Rhipicephalus Microplus.

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HIGHLIGHTS Zoonotic diseases in Brazil are socially determined and territorially patterned. High incidence clusters overlap with social deprivation and rural remoteness. Mortality declined while incidence persisted, revealing structural transmission drivers. A One Health approach must address inequality to effectively prevent zoonoses.

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HIGHLIGHTS BLV remains highly prevalent and impacts global cattle productivity. Molecular epidemiology reveals diverse genotypes and transmission patterns. Evidence suggests human exposure to BLV, but no confirmed infection. One Health framework is essential to assess zoonotic interfaces. Integrated surveillance is critical for effective control strategies